Sorbent cartridge configurations for improved dialysate regeneration

• US 9,855,379 B2
• Filed: 08/18/2015
• Issued: 01/02/2018
• Est. Priority Date: 02/02/2013
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Pudil, Bryant J., Meyer, Thomas E., Lura, David B., Gerber, Martin T.
• Primary Examiner(s): BASS, DIRK R
• Application Number:
  US14/828,853
• Publication Number:
  US 20150352270A1
• Time in Patent Office: 868 Days
• Field of Search: 2101952, 210646
• CPC Class Codes: A61M 1/1654 Dialysates therefor
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/167 Flexible packaging for solid concentrates
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 2205/02 characterised by a particular materials
• CPC Class Codes: B01D 15/08 Selective adsorption, e.g. chromatography

Abstract

A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.

Claims

1. A regeneration system, comprising:

a first regeneration module containing a first regenerative substance;

a second regeneration module containing the first regenerative substance; and

a first mixing chamber, wherein a first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first regenerative substance;

wherein the first regenerative substance removes at least one anionic waste species from the fluid.

2. The system of claim 1, wherein the at least one anion waste species comprises phosphate anions.

3. The system of claim 1, wherein the first regenerative substance is either zirconium oxide or activated alumina.

4. The system of claim 1, wherein the first regeneration module further comprises at least a second regenerative substance capable of converting urea to ammonium ions.

5. The system of claim 1, wherein the second regeneration module further comprises at least a second regenerative substance capable of converting urea to ammonium ions.

6. The system of claim 4, wherein the second regenerative substance comprises urease.

7. The system of claim 1, wherein second regeneration module further comprises a second regenerative substance;

wherein the second regenerative substance removes at least one cationic waste species from the fluid.

8. The system of claim 7, wherein the second chosen regenerative substance removes at least one waste species from the fluid selected from the group consisting of ammonium ions, calcium ion, potassium ions, magnesium ions, and sodium ions.

9. The system of claim 7, wherein the second regenerative substance is selected from the group consisting of magnesium phosphate and zirconium phosphate.

10. The system of claim 7, wherein either one or both of the regeneration modules contain urease.

11. The system of claim 1, wherein either one or both of the regeneration modules contain a regenerative substance capable of removing metals and uremic toxins.

12. The system of claim 11, wherein the regenerative substance capable of removing metals and uremic toxins is activated carbon.

13. A method comprising:

conveying a first outlet stream of a fluid from a mixing chamber to a first regeneration module comprising a regeneration substance capable of removing phosphate ions from the fluid;

returning the first outlet stream to the mixing chamber;

conveying a first inlet stream of a fluid to the mixing chamber and mixing the first inlet stream and first outlet stream; and

conveying a second outlet stream of the fluid from the mixing chamber to a second regeneration module comprising a regeneration substance capable of removing phosphate ions from the fluid.

14. The method of claim 13, wherein the regenerative substance capable of removing phosphate ions from the fluid is either zirconium oxide or activated alumina.

15. The method of claim 13, wherein the second regeneration module further comprises at least one regenerative substance capable of removing cations from the fluid.

16. The method of claim 15, wherein the second regeneration module comprises zirconium phosphate or magnesium phosphate.

17. The method of claim 13, further comprising:

conveying the second outlet stream from the second regeneration module to a second mixing chamber;

mixing a third inlet stream of the fluid entering the second mixing chamber with the second outlet stream;

conveying a third outlet stream from the second mixing chamber to the first mixing chamber; and

conveying a fourth outlet stream from the second mixing chamber to a third regeneration module comprising a regenerative substance capable of removing phosphate ions from the fluid.

18. The method of claim 15, wherein either the first regeneration module or second regeneration module comprises a regenerative substance capable of converting urea into ammonium ions;

and wherein the second regeneration module comprises a regenerative substance capable of removing ammonium ions from the fluid.

19. The method of claim 13, wherein the fluid is a dialysate solution.

20. The method of claim 13, wherein the fluid is a filtrate solution.