Automatic enhancement of an image stream of a moving organ and displaying as a movie

• US 9,855,384 B2
• Filed: 12/31/2009
• Issued: 01/02/2018
• Est. Priority Date: 03/08/2007
• Status: Active Grant

• Current Assignee: Sync-Rx, Ltd. (Koninklijke Philips N.V.)
• Original Assignee: Sync-Rx, Ltd. (Koninklijke Philips N.V.)
• Inventors: Cohen, Ran, Klaiman, Eldad, Steinberg, Alexander, Tolkowsky, David
• Primary Examiner(s): Akar, Serkan
• Application Number:
  US12/650,605
• Publication Number:
  US 20100172556A1
• Time in Patent Office: 2,924 Days
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00252 for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
• CPC Class Codes: A61B 2017/00694 with means correcting for movement of or for synchronisation with the body
• CPC Class Codes: A61B 2017/00703 correcting for movement of heart, e.g. ECG-triggered
• CPC Class Codes: A61B 2017/22044 with a pointed tip
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2090/3735 Optical coherence tomography [OCT]
• CPC Class Codes: A61B 2090/3762 using computed tomography systems [CT]
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 2576/02 specially adapted for a particular organ or body part
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/5217 extracting a diagnostic or physiological parameter from medical diagnostic data
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 8/0883 : for diagnosis of the heart
• CPC Class Codes: A61B 8/0891 : for diagnosis of blood vessels
• CPC Class Codes: A61B 8/543 : involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 90/37 : Surgical systems with images on a monitor during operation
• CPC Class Codes: A61F 2/958 : Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61M 2210/12 : Blood circulatory system
• CPC Class Codes: A61M 5/007 : for contrast media
• CPC Class Codes: G16H 50/30 : for calculating health indices; for individual health risk assessment

Abstract

Apparatus and methods are described for imaging a portion of a body of a subject that undergoes motion. A plurality of image frames of the portion are acquired. A stream of image frames is generated in which a vicinity of a given feature of the image frames is enhanced, by (a) automatically identifying the given feature in each of the image frames, (b) aligning the given feature in two or more of the image frames, (c) averaging sets of two or more of the aligned frames to generate a plurality of averaged image frames, and (d) displaying as a stream of image frames the plurality of averaged image frames. Other embodiments are also described.

Claims

1. A method for imaging a portion of a body of a subject that undergoes motion, the method comprising:

using an image-acquisition device, acquiring a plurality of image frames of the portion of the subject'"'"'s body;

using a processor, generating an enhanced movie of the portion of the subject'"'"'s body, in which a vicinity of a given feature of the image frames is enhanced, by;

automatically identifying the given feature in each of the plurality of acquired image frames,

aligning at least some of the image frames of the plurality of acquired image frames by aligning the given feature in the at least some of the image frames, and

averaging respective sets of two or more of the aligned frames to generate a plurality of averaged image frames, in which the vicinity of the given feature in the averaged image frames is enhanced, by components of the aligned frames that are not in the vicinity of the given feature being at least partially averaged out; and

using a display, displaying the enhanced movie of the portion of the subject'"'"'s body, by displaying, as a stream of image frames, the plurality of averaged image frames,

wherein acquiring the plurality of image frames comprises acquiring, sequentially, first and second image frames of the portion of the subject'"'"'s body,

wherein generating the enhanced movie of the portion of the subject'"'"'s body comprises;

generating a first moving-average image frame, in which the vicinity of a given feature is enhanced, using frames of the portion of the subject'"'"'s body that were acquired prior to the acquisition of the first and second acquired image frames;

aligning the given feature in the first acquired image frame with the given feature in the first moving-average image frame;

when the given feature in the first acquired image frame is aligned with the given feature in the first moving-average image frame, averaging the first acquired image frame with the first moving-average image frame to generate a second moving average image frame in which the vicinity of the given feature is enhanced;

aligning the given feature in the second moving-average image frame with the given feature in the second acquired image frame; and

when the given feature in the second moving-average image frame is aligned with the given feature in the second acquired image frame, averaging the second acquired image frame with the second moving-average image frame to generate a third moving-average image frame in which the vicinity of the given feature is enhanced, and

wherein displaying the enhanced movie of the portion of the subject'"'"'s body comprises displaying, in an image stream, the first, second, and third moving-average image frames.

2. The method according to claim 1, wherein generating the enhanced movie of the portion of the subject'"'"'s body comprises reducing visibility of regions of the image stream that are distant from the given feature.

3. The method according to claim 1, wherein identifying the given feature comprises identifying at least a portion of a tool that is disposed in the portion of the subject'"'"'s body.

4. The method according to claim 1, wherein acquiring the first and second image frames comprises acquiring the first and second image frames in cine mode.

5. The method according to claim 1, wherein acquiring the first and second image frames comprises acquiring the first and second image frames in fluoro mode.

6. The method according to claim 1, wherein generating the enhanced movie of the portion of the subject'"'"'s body, comprises generating the enhanced movie of the portion of the subject'"'"'s body in real time.

7. The method according to claim 1, wherein generating the enhanced movie of the portion of the subject'"'"'s body, comprises generating the enhanced movie of the portion of the subject'"'"'s body in near real time.

8. The method according to claim 1, wherein identifying the given feature comprises identifying an anatomical structure of the portion of the subject'"'"'s body.

9. The method according to claim 8,

wherein generating the enhanced movie of the portion of the subject'"'"'s body comprises generating an enhanced movie of the portion of the subject'"'"'s body in which the anatomical structure has a given visibility level, and

wherein acquiring the first and second image frames comprises acquiring the first and second image frames using a concentration of a contrast agent that is lower than a concentration of the contrast agent that would be required to generate a non-enhanced movie of the portion of the subject'"'"'s body in which the anatomical structure has the given visibility level.

10. The method according to claim 8, wherein identifying the given feature comprises identifying a lesion of the portion of the subject'"'"'s body, and wherein generating the enhanced movie of the portion of the subject'"'"'s body comprises generating an enhanced movie of the portion of the subject'"'"'s body in which a vicinity of the lesion is enhanced.

11. Apparatus for use with a portion of a body of a subject that undergoes motion, the apparatus comprising:

an image-acquisition device configured to acquire a plurality of image frames of the portion of the subject'"'"'s body;

a display; and

at least one processor configured to;

generate an enhanced movie of the portion of the subject'"'"'s body, in which a vicinity of a given feature of the image frames is enhanced, by;

receiving the plurality of acquired image frames,

automatically identifying the given feature in each of the acquired image frames,

aligning at least some of the image frames of the plurality of acquired image frames by aligning the given feature in the at least some of the image frames, and

averaging respective sets of two or more of the aligned frames to generate a plurality of averaged image frames, in which the vicinity of the given feature in the averaged image frames is enhanced, by components of the aligned frames that are not in the vicinity of the given feature being at least partially averaged out, and

drive the display to display the enhanced movie of the portion of the subject'"'"'s body, by displaying, as a stream of image frames, the plurality of averaged image frames, wherein;

the image-acquisition device is configured to acquire, sequentially, first and second image frames of the portion of the subject'"'"'s body, and

the processor is configured to;

generate the enhanced movie of the portion of the subject'"'"'s body by;

generating a first moving-average image frame, in which the vicinity of the given feature is enhanced, using frames of the portion of the subject'"'"'s body that were acquired prior to the acquisition of the first and second frames,

aligning the given feature in the first acquired image frame with the given feature in the first moving-average image frame,

when the given feature in the first image frame is aligned with the given feature in the first moving-average image frame, averaging the first acquired image frame with the first moving-average image frame to generate a second moving-average image frame in which the vicinity of the given feature is enhanced,

aligning the given feature in the second moving-average image frame with the given feature in the second acquired image frame,

when the given feature in the second moving-average image frame is aligned with the given feature in the second acquired image frame, averaging the second acquired image frame with the second moving-average image frame to generate a third moving-average image frame in which the vicinity of the given feature is enhanced, and

drive the display to display the enhanced movie of the portion of the subject'"'"'s body, by driving the display to display, in an image stream, the first, second, and third moving-average image frames.

12. The apparatus according to claim 11, wherein the processor is configured to reduce visibility of regions of the image stream that are distant from the given feature by generating the enhanced movie of the portion of the subject'"'"'s body.

13. The apparatus according to claim 11, wherein the processor is configured to identify the given feature by identifying at least a portion of a tool that is disposed in the portion of the subject'"'"'s body.

14. The apparatus according to claim 11, wherein the image-acquisition device is configured to acquire the first and second image frames in cine mode.

15. The apparatus according to claim 11, wherein the image-acquisition device is configured to acquire the first and second image frames in fluoro mode.

16. The apparatus according to claim 11, wherein the processor is configured to generate in real time the enhanced movie of the portion of the subject'"'"'s body.

17. The apparatus according to claim 11, wherein the processor is configured to generate in near real time the enhanced movie of the portion of the subject'"'"'s body.

18. The apparatus according to claim 11, wherein the processor is configured to identify the given feature by identifying an anatomical structure of the portion of the subject'"'"'s body.

19. The apparatus according to claim 18,

the apparatus being for use with a contrast agent having a concentration, the contrast agent being configured to facilitate the acquisition of the image frames by the image-acquisition device,

wherein the processor is configured to generate an enhanced movie of the portion of the subject'"'"'s body in which the anatomical structure has a given visibility level, and

wherein the contrast agent includes a contrast agent, a concentration of which is lower than a concentration of the contrast agent that would be required to generate a non-enhanced movie of the portion of the subject'"'"'s body in which the anatomical structure has the given visibility level.

20. The apparatus according to claim 18, wherein the processor is configured to:

identify the given feature by identifying a lesion of the portion of the subject'"'"'s body, and

generate the enhanced movie of the portion of the subject'"'"'s body, by generating an enhanced movie of the portion of the subject'"'"'s body, in which a vicinity of the lesion is enhanced.