X-ray detector for proton transit detection apparatus and method of use thereof

• US 9,855,444 B2
• Filed: 11/10/2016
• Issued: 01/02/2018
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: Lee W. Davis, Mark R. Amato, Scott Penfold
• Inventors: Penfold, Scott, Lee, W. Davis, Amato, Mark R.
• Primary Examiner(s): MCCORMACK, JASON L
• Application Number:
  US15/348,625
• Publication Number:
  US 20170056688A1
• Time in Patent Office: 418 Days
• Field of Search: 2504923
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 5/04 with beam-forming means

Abstract

The invention comprises a method and apparatus for probing a tumor of a patient using positively charged particles, comprising the steps of: (1) sequentially delivering sets of varied and known positively charged particles to a patient; (2) after transmission through the patient, sequentially detecting a residual energy of each of the sets of positively charged particles; and (3) determining a water equivalent thickness of a probed path of the patient using a plot of the detector response as a function of residual energy that is fit with a curve. The analyzer relates a half maximum of the fit curve, such as a Gaussian curve, to the water equivalent thickness of the sampled beam path. Repeated measurements as a function of incident angle and/or position of the incident charged particles allows generation of an image of the sample, such as a computed tomography image.

Claims

1. A method for probing a tumor of a patient using positively charged particles, comprising the steps of:

sequentially delivering from an output nozzle, connected to a first beam transport line, to the patient;

a first set of the positively charged particles comprising a first mean energy; and

a second set of the positively charged particles comprising a second mean energy, the second mean energy at least two megaelectronVolts different from the first mean energy;

after transmission through the patient, sequentially detecting;

a first residual energy of the first set of the positively charged particles; and

a second residual energy of the second set of the positively charged particles; and

determining a water equivalent thickness of a probed path of the patient using the first residual energy and the second residual energy.

2. The method of claim 1, said step of detecting further comprising the step of:

using an X-ray detector material to detect the positively charged particles.

3. The method of claim 2, said step of determining further comprising the step of:

fitting a Gaussian curve to a plurality of outputs derived from said X-ray detector material as a function of energy.

4. The method of claim 3, said step of determining further comprising the step of:

determining the water equivalent thickness using a half-height of the Gaussian curve.

5. The method of claim 4, further comprising the step of:

while maintaining said output nozzle and said X-ray detector material on opposite sides of the patient, repositioning said output nozzle.

6. The method of claim 5, said step of repositioning said output nozzle further comprising the steps of:

moving the output nozzle through an arc of at least forty-five degrees relative to the tumor without movement of a last beam magnet of said first beam transport line; and

coupling the output nozzle to a second beam transport line.

7. The method of claim 1, said step of delivering further comprising the steps of:

providing a beam transport path originating in a synchrotron and passing through said beam transport line;

changing the positively charged particles reaching said output nozzle, from the first mean energy to the second mean energy, by applying a radio-frequency timed potential difference across a gap radially crossing the beam transport path.

8. The method of claim 7, said step of delivering further comprising the step of:

moving said output nozzle from said first beam transport line to a second beam transport line.

9. The method of claim 2, said step of detecting further comprising the step of:

using said X-ray detector material to detect X-rays passed through the patient.

10. The method of claim 1, said step of detecting further comprising the step of:

using a single detector array to detect both;

(1) X-rays passed through the patient and (2) the first set of the positively charged particles.

11. An apparatus for probing a tumor of a patient using positively charged particles, comprising:

a beam transport line connected to an output nozzle configured to deliver to the patient;

(1) a first set of the positively charged particles comprising a first mean energy and (2) a second set of the positively charged particles comprising a second mean energy, the second mean energy at least two megaelectronVolts different from the first mean energy;

a detector positioned on an opposite side of said output nozzle from a patient position, said detector configured to sequentially detect;

(1) a first residual energy of the first set of the positively charged particles and (2) a second residual energy of the second set of the positively charged particles; and

a controller configured to determine a water equivalent thickness of a probed path of the patient using the first residual energy and the second residual energy.

12. The apparatus of claim 11, said detector comprising an X-ray detector material configured to detect protons comprising the first residual energy.

13. The apparatus of claim 12, said detector further comprising:

a scintillator configured to emit secondary photons upon passage of the first set of positively charged particles;

a photon detector configured to detect the secondary photons.

14. The apparatus of claim 11, said detector further comprising:

a first detector layer, of a set of detector layers, comprising a first thickness;

a second detector layer, of said set of detector layers, comprising a second thickness, said first thickness at least ten percent larger than said second thickness,

wherein said set of detector layers comprises at least three detector layers.

15. The apparatus of claim 11, said detector comprising a single layer detector array.

16. The apparatus of claim 11, further comprising:

a nozzle gantry configured to support said exit nozzle and an X-ray source, said nozzle gantry repositionable between at least two positions without movement of said beam transport line.

17. The apparatus of claim 16, said exit nozzle further comprising:

a first scanning magnet configured to scan along a first axis; and

a second scanning magnet configured to scan along a second axis, the first axis, a patient position, and the second axis forming an angle of greater than thirty degrees.

18. The apparatus of claim 17, further comprising:

a beam path switching magnet configured to redirect said beam transport line between at least three treatment lines, said gantry nozzle configured to connect said exit nozzle to a selected line of said at least three treatment lines.