Modulators of cystic fibrosis transmembrane conductance regulator

• US 9,856,248 B2
• Filed: 04/22/2016
• Issued: 01/02/2018
• Est. Priority Date: 08/11/2005
• Status: Active Grant

• Current Assignee: Vertex Pharmaceuticals Incorporated
• Original Assignee: Vertex Pharmaceuticals Incorporated
• Inventors: Hadida-Ruah, Sara, Van Goor, Fredrick, Miller, Mark, McCartney, Jason, Zhou, Jinglan, Arumugam, Vijayalaksmi
• Primary Examiner(s): Shiao, Rei Tsang
• Application Number:
  US15/136,159
• Publication Number:
  US 20160237079A1
• Time in Patent Office: 620 Days
• Field of Search: 548195
• CPC Class Codes: A61K 31/427 not condensed and containing further heterocyclic rings
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• CPC Class Codes: A61P 21/04 for myasthenia gravis
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• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
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• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/14 : of the thyroid hormones, e.g. T3, T4
• CPC Class Codes: A61P 5/18 : of the parathyroid hormones
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/04 : Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: A61P 7/10 : Antioedematous agents; Diuretics
• CPC Class Codes: A61P 7/12 : Antidiuretics, e.g. drugs for diabetes insipidus ADH A61P5/10
• CPC Class Codes: C07D 417/14 : containing three or more hetero rings

Abstract

The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.

Claims

1. A compound having formula I′

or formula II′

;