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Reagents for universal site-specific labeling and modifications of nucleic acids

  • US 9,856,285 B2
  • Filed: 03/17/2015
  • Issued: 01/02/2018
  • Est. Priority Date: 03/17/2015
  • Status: Active Grant
First Claim
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1. A method for modifying a nucleic acid molecule, comprising:

  • (a) monophosphoramidating H2N(CH2)nNH2 to the 5′

    end of the nucleic acid to form a conjugated product, wherein n is an integer from 2 to 6, and the conjugated product has a formula of;

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