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Monovalent binding proteins

  • US 9,856,319 B2
  • Filed: 12/27/2013
  • Issued: 01/02/2018
  • Est. Priority Date: 12/28/2012
  • Status: Active Grant
First Claim
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1. A monovalent, monospecific binding protein comprising at least two variable heavy domains, at least two variable light domains, and four polypeptide chains, wherein two of said four polypeptide chains comprise VDH-(X1)n-C—

  • (X2)n, whereinVDH is a heavy chain variable domain,X1 is a linker with the proviso that it is not CH1,C is a heavy chain constant domain,X2 is an Fc region,n is 0 or 1;

    andwherein two of said four polypeptide chains comprise VDL-(X3)n-C—

    (X4)n, whereinVDL is a light chain variable domain,X3 is a linker with the proviso that it is not CH1,C is a light chain constant domain,X4 does not comprise an Fc region;

    n is 0 or 1;

    wherein one of said at least two heavy chain variable domains and/or one of said at least two light chain variable domains comprises a non-naturally occurring mutation, wherein said mutation inhibits targeted binding between a specific antigen and—

    a mutant binding domain formed by the variable domain comprising the mutation.

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