Systems, methods, and computer readable storage media storing instructions for generating an image integrating functional, physiological and anatomical images

• US 9,858,687 B2
• Filed: 01/16/2013
• Issued: 01/02/2018
• Est. Priority Date: 01/17/2012
• Status: Active Grant

• Current Assignee: Emory University, Georgia Tech Research Corporation (University System of Georgia)
• Original Assignee: Emory University, Georgia Tech Research Corporation (University System of Georgia)
• Inventors: Oshinski, John N., Suever, Jonathan D., Lloyd, Michael S., Leon, Angel R.
• Primary Examiner(s): CESE, KENNY A
• Application Number:
  US13/742,648
• Publication Number:
  US 20130182929A1
• Time in Patent Office: 1,812 Days
• Field of Search: 382128, 382131
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 5/367 Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping
• CPC Class Codes: G01R 33/56325 Cine imaging
• CPC Class Codes: G06T 11/005 Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
• CPC Class Codes: G06T 2207/10072 Tomographic images
• CPC Class Codes: G06T 2207/10088 Magnetic resonance imaging [MRI]
• CPC Class Codes: G06T 2207/10096 Dynamic contrast-enhanced magnetic resonance imaging [DCE-MRI]
• CPC Class Codes: G06T 2207/20221 Image fusion; Image merging
• CPC Class Codes: G06T 2207/30048 Heart; Cardiac
• CPC Class Codes: G06T 3/14 Transformations for image registration, e.g. adjusting or mapping for alignment of images
• CPC Class Codes: G06T 7/33 using feature-based methods

Abstract

Systems, methods and computer-readable storage mediums relate to generating an image that includes functional, anatomical, and physiological images. The generated image may be an integrated image based on the functional image on which the anatomical and physiological images are mapped. The generated image may indicate more than one location of optimal lead placement. The generated image may be useful in pre-planning cardiac intervention procedures.

Claims

1. A method for generating an image including functional, anatomical, and physiological images of a heart of a patient, comprising:

processing a plurality of sets of magnetic resonance (MR) image data of a heart to generate a functional image, an anatomical image, and a physiological image of the heart, the plurality of sets of MR image data including a set of cine image data and one or more sets of contrast-enhanced image data,

the functional image being generated from the set of cine image data and being a contraction timing map that includes contraction timing and identifies areas of dyssynchrony, and

the physiological image and the anatomical image being generated from the one or more sets of contrast-enhanced image data, the physiological image including regional scar distribution;

generating an integrated image of the heart, the integrated image including functional, anatomical, and physiological images, the integrated image being based on the functional image on which the anatomical and physiological images are mapped;

determining one or more optimal lead placement locations for one or more leads of an implantable device; and

identifying the one or more optimal lead placement locations on the integrated image.

2. The method of claim 1, wherein the processing includes:

processing the set of cine image data to generate the functional image;

processing a first set of contrast-enhanced image data to generate the physiological image; and

processing a second set of contrast-enhanced image data to generate the anatomical image.

3. The method of claim 1, wherein the anatomical image includes coronary veins.

4. The method of claim 1, wherein:

the functional image is a dyssynchrony map;

an

the integrated image is an integrated map that includes the functional, anatomical, and physiological images, and the integrated map is based on the functional image on which the anatomical and physiological images overlap.

5. The method of claim 1, further comprising:

displaying a position of an interventional device on the integrated image.

6. The method according to claim 1, wherein one or more optimal lead placement locations are determined based on the contraction timing and the scar distribution.

7. The method according to claim 6, wherein each optimal lead placement location corresponds to a region of latest contraction that is not an area of significant scar.

8. The method according to claim 1, further comprising:

displaying the integrated image, wherein each of the one or more optimal lead placement locations is identified on the integrated image by a marker.

9. The method according to claim 1, wherein the contraction timing is of a left ventricle (LV) of the heart.

10. The method according to claim 1, wherein the processing the cine image data to generate the functional image includes determining movement of borders of the heart as a function of time for each location in the heart.

11. The method according to claim 10, wherein the borders include endocardial borders of the heart.

12. The method according to claim 1, wherein:

the anatomical image includes anatomy of the heart, and the anatomy of the heart includes coronary veins, and

the mapping the anatomical image to the functional image includes mapping a position of each coronary vein to the functional image.

13. A non-transitory computer-readable storage medium storing instructions for generating functional, physiological and anatomical images of a heart of a patient, the instructions comprising:

processing a plurality of sets of magnetic resonance (MR) image data of a heart to generate a functional image, an anatomical image, and a physiological image of the heart, the plurality of sets of MR image data including a set of cine image data and one or more sets of contrast-enhanced image data,

the functional image being generated from the set of cine image data and being a contraction timing map that includes contraction timing and identifies areas of dyssynchrony, and

the physiological image and the anatomical image being generated from the one or more sets of contrast-enhanced image data, the physiological image including regional scar distribution;

generating an integrated image of a heart, the integrated image including the functional, anatomical, and physiological images, the integrated image being based on the functional image on which the anatomical and physiological images are mapped;

determining one or more optimal lead placement locations for one or more leads of an implantable device; and

identifying the one or more optimal lead placement locations on the integrated image.

14. The non-transitory computer-readable storage medium of claim 13, wherein the anatomical image includes coronary veins.

15. The non-transitory computer-readable storage medium of claim 13, wherein one or more optimal lead placement locations are determined based on the contraction timing and the scar distribution.

16. The non-transitory computer-readable storage medium of claim 15, wherein each optimal lead placement location corresponds to a region of latest contraction that is not an area of significant scar.

17. The non-transitory computer-readable storage medium of claim 13, further comprising:

displaying the integrated image,

wherein each of the one or more optimal lead placement locations is identified on the integrated image by a marker.

18. The non-transitory computer-readable storage medium of claim 13, wherein the contraction timing is of a left ventricle (LV) of the heart.

19. The non-transitory computer-readable storage medium of claim 13, wherein the processing the cine image data to generate the functional image includes determining movement of borders of the heart as a function of time for each location in the heart.

20. The non-transitory computer-readable storage medium of claim 13, wherein:

the anatomical image includes anatomy of the heart, and the anatomy of the heart includes coronary veins, and

the mapping the anatomical image to the functional image includes mapping a position of each coronary vein to the functional image.