Articles of manufacture releasing an active ingredient

• US 9,861,154 B2
• Filed: 07/17/2009
• Issued: 01/09/2018
• Est. Priority Date: 07/18/2008
• Status: Active Grant

• Current Assignee: Nntt Tech Inc.
• Original Assignee: Biomod Collection Inc.
• Inventors: Theberge, Karine, Goudreault, Isabelle, Quirion, Francois, Perron, Gerald
• Primary Examiner(s): FISHER, MELISSA L
• Application Number:
  US12/680,836
• Publication Number:
  US 20100226947A1
• Time in Patent Office: 3,098 Days
• Field of Search: None
• CPC Class Codes: A43B 1/0045 made at least partially of deodorant means
• CPC Class Codes: A43B 17/003 characterised by the material made of wood A43B17/12, made of sponge, rubber or plastic materials A43B17/14
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: D06M 23/08 Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00
• CPC Class Codes: D06M 23/12 Processes in which the treating agent is incorporated in microcapsules making microcapsules B01J13/02

Abstract

The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

Claims

1. An article for applying an active ingredient to a living subject, comprising:

a) a substrate in a substantially dry condition;

b) the substrate carrying a population of hydrophobic microparticles dispersed in a formulation that contacts the substrate,

the hydrophobic microparticles having substantially hydrophobic outer surfaces, and

the hydrophobic microparticles and the substantially hydrophobic outer surfaces of the hydrophobic microparticles including a non-crosslinked carrier material throughout which is dispersed the active ingredient, wherein the non-crosslinked carrier material includes one or more of a lipid, a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride,

wherein the activity, temperature, pH, or any combination thereof of the living subject triggers progressive erosion of the outer surfaces of the hydrophobic microparticles so as to release the non-crosslinked carrier material and the active ingredient for transfer to the living subject, and

wherein the article is configured to place the substantially hydrophobic outer surfaces of the hydrophobic microparticles into contact with the living subject; and

wherein the article optionally comprises a cationic surfactant, the cationic surfactant being present in the formulation, exterior to the microparticles.

2. An article as defined in claim 1, wherein the non-crosslinked carrier material further includes a fatty alcohol.

3. An article as defined in claim 1, wherein the non-crosslinked carrier material further includes an emollient.

4. An article as defined in claim 1, wherein the non-crosslinked carrier material further includes a binding agent.

5. An article as defined in claim 1, wherein one or more of the hydrophobic microparticles have a size in the range from about 0.1 μ

m to about 200 μ

m.

6. An article as defined in claim 1, wherein the hydrophobic microparticles have a melting temperature between about 20°

C. and about 60°

C.

7. An article as defined in claim 1, having a release index between 2 and 7.

8. An article as defined in claim 1, wherein the active ingredient is a cosmetic agent, a therapeutic agent, a pharmaceutical agent, a nutraceutical agent, a cleansing agent, a detoxifying agent or a fragrance or any combination thereof.

9. An article as defined in claim 1, wherein the substrate comprises fibers, and interstices are formed between the fibers.

10. An article as defined in claim 9, wherein the hydrophobic microparticles are retained within the interstices of the substrate.

11. An article as defined in claim 9, wherein the hydrophobic microparticles are retained on the fibers of the substrate.

12. An article as defined in claim 1, wherein after having been through 5 wash cycles, the article still maintains a positive active ingredient release rate.

13. An article as defined in claim 12, wherein the article having been through 20 wash cycles still maintains a positive active ingredient release rate.

14. An article as defined in claim 12, wherein the article maintains a constant rate of release of the active ingredient between 10 and 20 wash cycles.

15. An article as defined in claim 1, wherein release of the active ingredient is maintained between 15 and 20 wash cycles at a rate that is about 2 to about 3 times the rate between 30 and 40 wash cycles.

16. An article as defined in claim 1, wherein the substrate is composed of a material selected from the group consisting of woven materials, non-woven materials, fibrous textiles, non-fibrous textile, fabrics, synthetic materials, papers and paper products, products made from composites, products made from polymers, products made from wood or wood by-products, products made from carbon fiber, products made from glass fiber, and synthetic foam.

17. An article as defined in claim 1, wherein the substrate is composed of a material selected from the group consisting of cotton, linen, jute, wool, silk, asbestos, viscose, polyesters, nylons, acetates, polypropylenes, rayon, papers, woods, glass fibers, carbon fibers, polyethylenes, polystyrenes, polyurethanes, polyethylene terephthalate (PET), aramide, polyvinyl derivatives, polylactides, polyhydroxyalkanoates, cellulose esters polyethylene, polyester/elastane blends, polyamides, polyamide/elastane blends, cotton/polyester/elastane blends, polyacrylonitriles, lyocell and linens.

18. An article as defined in claim 1, wherein the microparticles have a melting temperature between 31°

C. and 33°

C.

19. An article as defined in claim 1, wherein the hydrophobic microparticles form a perception indicator on the substrate.

20. An article as defined in claim 19, wherein the perception indicator is a) a visual indicator;

b) a wear indicator;

or c) a combination of a) and b).

21. An article as defined in claim 1, the hydrophobic microparticles being entirely made of a mixture of the non-crosslinked carrier material and the active ingredient, wherein the non-crosslinked carrier material and the active ingredient are uniformly distributed throughout the hydrophobic microparticles.

22. The article according to claim 1, wherein the hydrophobic microparticles consist of a non-crosslinked carrier material throughout which is dispersed the active ingredient.

23. The article according to claim 22, wherein the non-crosslinked carrier material consists of one or more of a lipid, a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride.

24. An article for applying an active ingredient to a living subject, comprising:

a) a substrate in a substantially dry condition;

b) the substrate carrying a population of hydrophobic microparticles dispersed in a formulation that contacts the substrate,

the hydrophobic microparticles having electrostatically uncharged outer surfaces, and

the hydrophobic microparticles and the electrostatically uncharged outer surfaces of the hydrophobic microparticles including a non-crosslinked carrier material throughout which is dispersed the active ingredient, wherein the non-crosslinked carrier material includes one or more of a lipid, a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride,

wherein the activity, temperature, pH, or any combination thereof of the living subject triggers progressive erosion of the electrostatically uncharged outer surfaces of the hydrophobic microparticles so as to release the non-crosslinked carrier material and the active ingredient for transfer to the living subject, and

wherein the article is configured to place the electrostatically uncharged outer surfaces outer surfaces of the hydrophobic microparticles into contact with the living subject.

25. A hydrophobic microparticle for delivery of an active ingredient to a living subject, the hydrophobic microparticle having a body, the body comprising a central part having a surface, wherein the surface is substantially hydrophobic;

the central part and its surface including a non-crosslinked carrier material throughout which is dispersed the active ingredient, wherein the non-crosslinked carrier material includes one or more of a lipid, a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride,

wherein the temperature and/or the pH of the living subject triggers progressive erosion of the surface and the subsequent progressive erosion of the central part, to release the non-crosslinked carrier material and the active ingredient for transfer to the living subject; and

wherein, in a pre-usage form, at least a portion of the surface of the central part is exposed to the environment exterior to the microparticle; and

wherein the microparticle optionally comprises a cationic surfactant, the cationic surfactant being present on the surface of the microparticle.

26. A microparticle as defined in claim 25, wherein the microparticle further includes a binding agent.

27. A microparticle as defined in claim 25, wherein one or more of the microparticles have a size in the range from about 0.1 μ

m to about 200 μ

m.

28. A microparticle as defined in claim 25, wherein the microparticles have a melting temperature between about 20°

C. and about 60°

C.