Marker delivery device with releasable plug

• US 9,861,294 B2
• Filed: 01/29/2015
• Issued: 01/09/2018
• Est. Priority Date: 02/02/1999
• Status: Expired due to Fees

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Jones, Michael L., Lubock, Paul, Merritt, John
• Primary Examiner(s): NGUYEN, TUAN VAN
• Application Number:
  US14/608,939
• Publication Number:
  US 20150141805A1
• Time in Patent Office: 1,076 Days
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 2090/3954 magnetic, e.g. NMR or MRI
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 2123/00 Preparations for testing in vivo
• CPC Class Codes: A61K 49/12 Macromolecular compounds
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/007 for contrast media

Abstract

A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. A plunger is slidably disposed within the inner lumen of the elongated delivery cannula. The plunger has a distal end. At least one elongated fibrous marker body is pre-formed prior to being inserted into the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula at a location distal to the distal end of the plunger. The pre-formed at least one elongated fibrous marker body includes a fibrous material compressed and impregnated with a binding agent and freeze dried in the compressed condition. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body.

Claims

1. A marker delivery device for use in marking an intracorporeal tissue site, comprising:

an elongated delivery cannula which has a distal end section, an inner lumen, and a discharge opening in the distal end section in communication with the inner lumen;

a plunger slidably disposed within the inner lumen of the elongated delivery cannula, the plunger having a distal end;

at least one elongated fibrous marker body having a plurality of layers of fibrous material that is pre-formed prior to being inserted into the inner lumen of the elongated delivery cannula, the at least one elongated fibrous marker body being slidably disposed within the inner lumen of the elongated delivery cannula at a location distal to the distal end of the plunger, the pre-formed at least one elongated fibrous marker body being compressed and impregnated with a binding agent and freeze dried in the compressed condition; and

a releasable plug disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body.

2. The marker delivery device of claim 1, wherein the at least one elongated fibrous marker body comprises a plurality of bioabsorbable polymeric strands.

3. The marker delivery device of claim 1, wherein the fibrous material is oxidized cellulose.

4. The marker delivery device of claim 1, wherein the fibrous material is oxidized regenerated cellulose.

5. The marker delivery device of claim 1, wherein the at least one elongated fibrous marker body is formed from:

a mixture of oxidized regenerated cellulose and a polymer selected from a group consisting of polylactic acid, polyglycolic acid, a co-polymer of polylactic acid and polyglycolic acid, polycaprolactone, and collagen; and

the binding agent, wherein the binding agent is selected from the group consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone.

6. The marker delivery device of claim 1, wherein the binding agent is selected from a group consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone.

7. The marker delivery device of claim 1, comprising an MRI detectable marker element attached to the at least one elongated fibrous marker body.

8. The marker delivery device of claim 1, wherein the elongated delivery cannula has a plurality of markings regularly spaced along the elongated delivery cannula.

9. The marker delivery device of claim 1, wherein the discharge opening is a lateral discharge opening on the elongated delivery cannula.

10. The marker delivery device of claim 1, wherein each of the plurality of layers is formed of the same fibrous material.

11. A marker delivery device for use in marking an intracorporeal tissue site, comprising:

an elongated delivery cannula having a distal end section, a discharge opening in the distal end section, and an inner lumen extending to and in communication with the discharge opening;

a plurality of elongated fibrous marker bodies slidably disposed within the inner lumen of the elongated delivery cannula proximal to the discharge opening, each of the plurality of elongated fibrous marker bodies having a length and comprising a plurality of bioabsorbable fibers which are configured into a plurality of layers, compressed, and bound together with a synthetic polymer binding agent so as to form the length prior to insertion of the plurality of elongated fibrous marker bodies into the elongated delivery cannula; and

a plunger slidably disposed within the inner lumen of the elongated delivery cannula, the plunger having a pusher end located proximal to the plurality of elongated fibrous marker bodies in the inner lumen.

12. The marker delivery device of claim 11, wherein each of the plurality of elongated fibrous marker bodies is expandable upon contact with body fluid or other water based fluid.

13. The marker delivery device of claim 11, comprising an MRI detectable marker element attached to at least one of the plurality of elongated fibrous marker bodies.

14. The marker delivery device of claim 11, wherein the elongated delivery cannula has a plurality of markings regularly spaced along the elongated delivery cannula.

15. The marker delivery device of claim 11, wherein each of the plurality of layers is formed of the same bioabsorbable fibers.

16. A marker delivery device for use in marking an intracorporeal site within a patient, comprising:

an elongated delivery cannula which has a distal end, a discharge opening in the distal end, and an inner lumen extending to and in communication with the discharge opening;

a plunger slidably disposed within the inner lumen of the elongated delivery cannula, the plunger having a pusher end;

at least one short term marker body disposed within the inner lumen proximal to the discharge opening of the elongated delivery cannula and distal to the pusher end of the plunger, the at least one short term marker body configured for remote detection for at least two weeks but not longer than one year; and

an elongated fibrous marker body pre-formed prior to being inserted into the inner lumen of the elongated delivery cannula, the elongated fibrous marker body being slidably disposed within the inner lumen proximal to the at least one short term marker and distal to the pusher end of the plunger, the elongated fibrous marker body comprising a plurality of layers of compressed bioabsorbable fibers bound in a compressed condition by a polymer binding agent.

17. The marker delivery device of claim 16, wherein the elongated fibrous marker body is formed from oxidized cellulose.

18. The marker delivery device of claim 16, wherein the elongated fibrous marker body is formed from oxidized regenerated cellulose.

19. The marker delivery device of claim 16, wherein the elongated fibrous marker body is formed from a mixture of oxidized regenerated cellulose and a polymer selected from a group consisting of polylactic acid, polyglycolic acid, a co-polymer of polylactic acid and polyglycolic acid, polycaprolactone, and collagen.

20. The marker delivery device of claim 16, wherein the polymer binding agent is selected from a group consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone.