Adhesive functional strip for transcutaneous fluorescence measurement

• US 9,861,315 B2
• Filed: 09/04/2013
• Issued: 01/09/2018
• Est. Priority Date: 09/13/2012
• Status: Active Grant

• Current Assignee: Lohmann GmbH & Company KG, MediBeacon Inc.
• Original Assignee: Lohmann GmbH & Company KG
• Inventors: Gretz, Norbert, Schock-Kusch, Daniel, Herbertz, Michael, Nittenwilm, Ralf
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US14/427,889
• Publication Number:
  US 20150245799A1
• Time in Patent Office: 1,588 Days
• CPC Class Codes: A61B 2560/0285 Apparatus for single use
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/4244 liver
• CPC Class Codes: A61B 5/425 pancreas
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/68335 including release sheets or liners
• CPC Class Codes: C08K 3/04 Carbon
• CPC Class Codes: C09J 133/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C09J 2301/1242 the opposite adhesive layers being different
• CPC Class Codes: C09J 2301/302 the adhesive being pressure-sensitive, i.e. tacky at temperatures inferior to 30°C
• CPC Class Codes: C09J 2301/408 additives as essential feature of the adhesive layer
• CPC Class Codes: C09J 2400/22 Presence of unspecified polymer
• CPC Class Codes: C09J 2421/00 Presence of unspecified rubber
• CPC Class Codes: C09J 2433/00 Presence of (meth)acrylic polymer
• CPC Class Codes: C09J 2467/006 : in the substrate
• CPC Class Codes: C09J 2483/00 : Presence of polysiloxane
• CPC Class Codes: C09J 2483/005 : in the release coating
• CPC Class Codes: C09J 7/22 : Plastics; Metallised plastics
• CPC Class Codes: C09J 7/38 : Pressure-sensitive adhesives [PSA]
• CPC Class Codes: C09J 7/381 : based on macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds

Abstract

The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

Claims

1. An adhesive functional strip for transcutaneous fluorescence measurement of general organ functions or metabolic organ disorders by a sensor, characterised in that the strip consists of a laminate of layers in the following order:

a backing-less transparent transfer adhesive strip or transparent adhesive tape provided on both sides with a pressure-sensitive adhesive coating provided for direct application to the skin;

a transparent film;

at least one light-absorbing pressure-sensitive adhesive layer for absorbing diffused light so that a fluorescence measurement is not disturbed, comprising at least one recess representing an optical window for the sensor to examine the skin; and

a stabilizing transparent cover stabilizing the entire strip.

2. The adhesive functional strip according to claim 1, characterised in that a circumferential sealing frame comprising four sealing strips is applied on a side of the adhesive functional strip which is remote from the skin, the production of which frame is particularly integrated in the production process of the functional patch, and which thus is an integral component of the functional patch.

3. The adhesive functional strip according to claim 1, characterised in that the transfer adhesive strip or the transparent adhesive tape which is suitable and approved for applications to the skin comprises an adhesive on the basis of either acrylate, silicone or rubber.

4. The adhesive functional strip according to claim 1, characterised in that the at least one light-absorbing pressure-sensitive adhesive layer consists of a soot-pigmented and consequently black adhesive on the basis of acrylate, silicone or rubber.

5. The adhesive functional strip according to claim 1, characterised in that the light-absorbing pressure-sensitive adhesive layer is present in the form of a backing-based adhesive tape provided on both sides with a soot-pigmented and consequently black adhesive on the basis of acrylate, silicone or rubber.

6. The adhesive functional strip according to claim 1, characterised in that the light-absorbing pressure-sensitive adhesive layer(s) contains/contain a recess therethrough to provide a direct light contact both of a sensor head which is equipped with LED light and also of a photodiode with the skin.

7. The adhesive functional strip according to claim 1, characterised in that the double-sided light-absorbing adhesive tape contains a plurality of window-shaped recesses therethrough located next to one another and separated from one another by light-impermeable webs, to provide a direct light contact both of a sensor head equipped with LED light and also of a photodiode with the skin.

8. The adhesive functional strip according to claim 2, characterised in that the sealing strips consist of a foam coated on both sides with an adhesive on the basis of acrylate, silicone or rubber.

9. The adhesive functional strip according to claim 1, characterised in that the strip is reusable several times.

10. The adhesive functional strip according to claim 1, wherein a circumferential sealing frame comprising four sealing strips is applied on a side of the adhesive functional strip which is remote from the skin, wherein the adhesive functional patch is present as one of a separate sealing frame which is to be attached before the application of the sensor, and as a sealing frame which is connected to the sensor and therefore is to be fastened simultaneously with the application of the sensor.

11. The adhesive functional strip according to claim 1, wherein the adhesive functional strip is a disposable product.