Methods, devices, and systems for blood flow

• US 9,861,410 B2
• Filed: 05/06/2016
• Issued: 01/09/2018
• Est. Priority Date: 05/06/2016
• Status: Active Grant

• Current Assignee: Medos International Sarl (Johnson & Johnson)
• Original Assignee: Medos International Sarl (Johnson & Johnson)
• Inventors: Whittaker, Gregory R., Cleveland, Benjamin, Hwang, Julia, Spenciner, David B., Parrish, William R., Marks, Jacob A., Sengun, Mehmet Z., Bittenson, Steven N., Theis, Regan A.
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): MERCIER, MELISSA S
• Application Number:
  US15/148,464
• Publication Number:
  US 20170319250A1
• Time in Patent Office: 613 Days
• Field of Search: None
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/0412 having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/0445 cannulated, e.g. with a longitudinal through-hole for passage of an instrument
• CPC Class Codes: A61B 2017/045 snug fit within the anchor
• CPC Class Codes: A61B 2017/0458 Longitudinal through hole, e.g. suture blocked by a distal suture knot
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0043 characterised by structural features

Abstract

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure.

Claims

1. A surgical method, comprising:

forming a hole in a bone of a patient in a soft tissue repair procedure;

implanting an implant in the hole, the implant including an anti-coagulation agent, wherein the implant is a tubular member, and an inner lumen of the tubular member is occluded when the implant is implanted in the hole such that the blood is prevented from flowing through the implanted implant until a selected amount of time has lapsed after completion of the soft tissue repair procedure, and wherein the implant has a suture extending therefrom; and

pulling the suture from outside the patient'"'"'s body and thereby removing a plug from the inner lumen of the tubular member.

2. The method of claim 1, wherein the implant is made from an energy activated material disposed therein that occludes the inner lumen, and the method further comprises, after the selected amount of time has elapsed, activating the energy activated material by application of energy thereto.

3. The method of claim 1, wherein the implant includes a retaining member configured to engage the bone in which the implant is implanted to retain the implant within the bone.

4. The method of claim 1, wherein the implant is bioabsorbable.

5. The method of claim 1, wherein the implant is not bioabsorbable.

6. The method of claim 1, wherein the anti-coagulation agent is coated on a surface of the implant.

7. The method of claim 1, wherein the anti-coagulation agent is impregnated in a material forming the implant.

8. The method of claim 1, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

9. The method of claim 1, wherein the implant is an anchor, and the anchor has at least one bone-engaging surface feature on an exterior surface thereof that engages the bone to secure the anchor in the hole.

10. The method of claim 1, further comprising implanting an anchor in the bone at a site a distance away from a site where the implant is implanted, wherein the implant is a tubular member that is not connected to the anchor with any implanted matter.

11. A surgical method, comprising:

forming a hole in a bone of a patient in a soft tissue repair procedure;

implanting an implant in the hole, the implant including an anti-coagulation agent, wherein the implant is a tubular member, and an inner lumen of the tubular member is occluded when the implant is implanted in the hole such that the blood is prevented from flowing through the implanted implant until a selected amount of time has lapsed after completion of the soft tissue repair procedure, and wherein the implant includes a knitted material that occludes the inner lumen; and

pulling the knitted material after the selected amount of time has elapsed to cause the knitted material to unravel.

12. The method of claim 11, wherein the implant is an anchor, and the anchor has at least one bone-engaging surface feature on an exterior surface thereof that engages the bone to secure the anchor in the hole.

13. The method of claim 11, further comprising implanting an anchor in the bone at a site a distance away from a site where the implant is implanted, wherein the implant is a tubular member that is not connected to the anchor with any implanted matter.

14. The method of claim 11, wherein the implant includes a retaining member configured to engage the bone in which the implant is implanted to retain the implant within the bone.

15. The method of claim 11, wherein the implant is bioabsorbable.

16. The method of claim 11, wherein the implant is not bioabsorbable.

17. The method of claim 11, wherein the anti-coagulation agent is coated on a surface of the implant.

18. The method of claim 11, wherein the anti-coagulation agent is impregnated in a material forming the implant.

19. The method of claim 11, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.