Apparatus and methods for tracking administering of medication by syringe

• US 9,861,756 B1
• Filed: 04/20/2016
• Issued: 01/09/2018
• Est. Priority Date: 03/08/2016
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Krasnow, Benjamin David, Smith, Peter Howard, Deyle, Travis, Mirov, Russell
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): Legette-Thompson, Tiffany
• Application Number:
  US15/133,396
• Time in Patent Office: 629 Days
• Field of Search: 604 67, 604207, 604189, 604506, 604246
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31533 Dosing mechanisms, i.e. setting a dose administrating mechanisms A61M5/31565
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: G01F 11/027 of the syringe type
• CPC Class Codes: G01F 23/2962 Measuring transit time of reflected waves

Abstract

An apparatus and methods for tracking administering of medication by syringes is provided. The apparatus may include a plunger head for a syringe. The plunger head may include a transducer that sends and receives ultrasonic signals. The plunger may also include an antenna and a microcontroller that interfaces with the transducer and the antenna. The plunger may also include a power source that powers the microcontroller and the transducer. The transducer, the antenna, the microcontroller, and the power source may be at least partially encapsulated in an elastomer housing that fits within a barrel of the syringe. The microcontroller may be programmed with instructions to calculate data representative of the quantity of medication dispensed from the barrel and transmit the data to a remote device via the antenna.

Claims

1. A plunger head for a syringe, comprising:

an ultrasonic transducer disposed within the plunger head for sending and receiving ultrasonic signals from the plunger head;

an antenna;

a microcontroller that interfaces with the ultrasonic transducer and the antenna; and

a power source that powers the microcontroller and the ultrasonic transducer, wherein the ultrasonic transducer, the antenna, the microcontroller, and the power source are at least partially encapsulated in an elastomer housing that fits within a barrel of the syringe, wherein the ultrasonic transducer is positioned within the plunger head to propagate the ultrasonic signals from the plunger head along a length of the barrel extending towards a dispensing end of the barrel when the plunger head is inserted in the syringe; and

wherein the microcontroller includes instructions to calculate data representative of a quantity of medication dispensed from the barrel and transmit the data to a remote device via the antenna, wherein the instructions, when executed by the microcontroller, cause the microcontroller to calculate the quantity of medication dispensed by;

measuring a time for the ultrasonic signals to travel from the ultrasonic transducer to the dispensing end of the barrel and return to the ultrasonic transducer.

2. The plunger head of claim 1, wherein the microcontroller registers a date and time the medication is dispensed and transmits the date and time to the remote device along with the quantity of medication dispensed.

3. The plunger head of claim 1, further comprising a temperature sensor that measures a temperature of the medication, wherein the plunger head compensates for changes in the temperature of the medication when calculating the data representative of the quantity of medication dispensed.

4. The plunger head of claim 1, further comprising electrodes that measure a conductivity of the medication, wherein the plunger head using the ultrasonic signals measures a density, and a viscosity of the medication, and based on the conductivity, the density, and the viscosity, the plunger head profiles the medication.

5. The plunger head of claim 1, further comprising a crystal oscillator that keeps a time and date, wherein the crystal oscillator is a 10 MHZ crystal oscillator, which provides sufficient time accuracy to enable a position of the plunger head to be measured to within 150 microns.

6. The plunger head of claim 1, wherein the power source is rechargeable via an inductive charging system.

7. The plunger head of claim 1, wherein the plunger head detects air bubbles in the medication within the barrel by receiving echoes within the ultrasonic signals with the ultrasonic transducer.

8. The plunger head of claim 1, wherein the microcontroller is configured to store the data representative of the quantity of medication dispensed from the barrel until the remote device initiates transmission of the data to the remote device.

9. The plunger head of claim 1, wherein the instructions, when executed by the microcontroller, cause the microcontroller to calculate the quantity of medication dispensed by further:

calculating a position of the plunger head within the syringe based on the measuring; and

calculating the quantity of medication dispensed based on changes in the position.

10. The plunger head of claim 1, further comprising a force sensor, wherein the plunger head determines when dispensing of the medication is initiated based on a force detected by the force sensor.

11. The plunger head of claim 10, wherein the plunger head operates in a low-power sleep mode until dispensing of the medication is initiated and then the ultrasonic transducer begins sending and receiving the ultrasonic signals.

12. A plunger head for a medication injection device, comprising:

an ultrasonic transducer disposed within the plunger head for sending and receiving ultrasonic signals from the plunger head;

an antenna;

a microcontroller that interfaces with the ultrasonic transducer and the antenna; and

a power source that powers the microcontroller and the ultrasonic transducer, wherein the ultrasonic transducer, the antenna, the microcontroller, and the power source are at least partially encapsulated in an elastomer housing that fits within a barrel of the medication injection device, wherein the ultrasonic transducer is positioned within the plunger head to propagate the ultrasonic signals from the plunger head along a length of the barrel extending towards a dispensing end of the barrel when the plunger head is inserted in the medication injection device; and

wherein the microcontroller includes instructions to calculate data representative of a quantity of medication dispensed from the barrel and transmit the data to a remote device via the antenna, wherein the instructions, when executed by the microcontroller, cause the microcontroller to calculate the quantity of medication dispensed by;

measuring a time for the ultrasonic signals to travel from the ultrasonic transducer to the dispensing end of the barrel and return to the ultrasonic transducer.