Therapeutic window determination
First Claim
1. A method comprising:
- receiving, by a processor, an input indicative of at least one of an efficacious result or an adverse-effect result of a delivery of electrical stimulation therapy to a patient by a medical device according to at least one electrical stimulation parameter value;
determining, by the processor, a volume of tissue activation expected to result from the delivery of electrical stimulation to the patient according to the at least one electrical stimulation parameter value;
determining, by the processor, one or more voxels of a grid that overlap with the volume of tissue activation, wherein the grid comprises a plurality of voxels, and wherein each voxel of the plurality of voxels is associated with a respective voxel value; and
modifying, by the processor and based on the input, a voxel value of at least one of the one or more voxels of the grid that overlap with the volume of tissue activation.
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Accused Products
Abstract
A therapeutic window for at least one electrode of a medical system may be determined based on a volume of tissue expected to be activated (“VTA”) by electrical stimulation delivered by the at least one electrode. In some examples, a processor determines the therapeutic window for a particular electrode by at least determining an efficacy threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the efficacy threshold, and determining an adverse-effects threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the adverse-effects threshold.
26 Citations
34 Claims
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1. A method comprising:
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receiving, by a processor, an input indicative of at least one of an efficacious result or an adverse-effect result of a delivery of electrical stimulation therapy to a patient by a medical device according to at least one electrical stimulation parameter value; determining, by the processor, a volume of tissue activation expected to result from the delivery of electrical stimulation to the patient according to the at least one electrical stimulation parameter value; determining, by the processor, one or more voxels of a grid that overlap with the volume of tissue activation, wherein the grid comprises a plurality of voxels, and wherein each voxel of the plurality of voxels is associated with a respective voxel value; and modifying, by the processor and based on the input, a voxel value of at least one of the one or more voxels of the grid that overlap with the volume of tissue activation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system comprising:
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a memory that stores a grid comprising a plurality of voxels, wherein each voxel of the plurality of voxels is associated with a respective voxel value; and a processor configured to; receive an input indicative of at least one of an efficacious result or an adverse-effect result of a delivery of electrical stimulation therapy to a patient by a medical device according to at least one electrical stimulation parameter value, determine a volume of tissue activation expected to result from the delivery of electrical stimulation to the patient according to the at least one electrical stimulation parameter value, determine one or more voxels of the grid that overlap with the volume of tissue activation, and modify, based on the input, a voxel value of at least one of the one or more voxels of the grid that overlap with the volume of tissue activation. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A system comprising:
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means for receiving an input indicative of at least one of an efficacious result or an adverse-effect result of a delivery of electrical stimulation therapy to a patient by a medical device according to at least one electrical stimulation parameter value; means for determining a volume of tissue activation expected to result from the delivery of electrical stimulation to the patient according to the at least one electrical stimulation parameter value; means for determining one or more voxels of a grid that overlap with the volume of tissue activation, wherein the grid comprises a plurality of voxels, and wherein each voxel of the plurality of voxels is associated with a respective voxel value; and means for modifying, based on the input, a voxel value of at least one of the one or more voxels of the grid that overlap with the volume of tissue activation.
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34. A non-transitory computer-readable medium comprising instructions that, when executed by a processor, cause the processor to:
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receive an input indicative of at least one of an efficacious result or an adverse-effect result of a delivery of electrical stimulation therapy to a patient by a medical device according to at least one electrical stimulation parameter value; determine a volume of tissue activation expected to result from the delivery of electrical stimulation to the patient according to the at least one electrical stimulation parameter value; determine one or more voxels of a grid that overlap with the volume of tissue activation, wherein the grid comprises a plurality of voxels, and wherein each voxel of the plurality of voxels is associated with a respective voxel value; and modify, based on the input, a voxel value of at least one of the one or more voxels of the grid that overlap with the volume of tissue activation.
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Specification