Single domain antibodies against SOD1 and their use in medicine
First Claim
Patent Images
1. A single-domain antibody against the enzyme superoxide dismutase (“
- SOD1”
),wherein the single-domain antibody comprises a peptide that binds with both wild-type and mutant SOD 1, wherein the single-domain antibody is able to block fibril formation by SOD 1, and wherein;
(a) the single-domain antibody comprises a peptide selected from the group consisting of SEQ ID NOS;
1-14, or(b) the single-domain antibody comprises an amino acid sequence comprising a set of three complementarity determining regions (CDRs), wherein the set of CDRs is selected from;
i. SEQ ID NOs;
15, 16 and 17;
ii. SEQ ID NOs;
18, 20 and 21;
iii. SEQ ID NOs;
19, 20 and 21;
iv. SEQ ID NOs;
22, 24 and 25;
v. SEQ ID NOs;
23, 24 and 25;
orvi. SEQ ID NOs;
26, 27 and 28.
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Abstract
The present application relates to the field of single-domain antibodies (also called nanobodies), more particularly single-domain antibodies against SOD1 protein isoforms. It also relates to the use of these nanobodies in medicine. Accordingly, methods to treat a disease using these nanobodies are provided herein. The single-domain antibodies are particularly envisaged for treatment of ALS.
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Citations
15 Claims
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1. A single-domain antibody against the enzyme superoxide dismutase (“
- SOD1”
),wherein the single-domain antibody comprises a peptide that binds with both wild-type and mutant SOD 1, wherein the single-domain antibody is able to block fibril formation by SOD 1, and wherein; (a) the single-domain antibody comprises a peptide selected from the group consisting of SEQ ID NOS;
1-14, or(b) the single-domain antibody comprises an amino acid sequence comprising a set of three complementarity determining regions (CDRs), wherein the set of CDRs is selected from; i. SEQ ID NOs;
15, 16 and 17;ii. SEQ ID NOs;
18, 20 and 21;iii. SEQ ID NOs;
19, 20 and 21;iv. SEQ ID NOs;
22, 24 and 25;v. SEQ ID NOs;
23, 24 and 25;
orvi. SEQ ID NOs;
26, 27 and 28. - View Dependent Claims (2, 3, 4, 5, 13, 14, 15)
- SOD1”
-
6. A single-domain antibody against the enzyme superoxide dismutase (“
- SOD1”
),wherein the single-domain antibody comprises a peptide selected from the group consisting of SEQ ID NOs;
1-14 orwherein a complementarity-determining region (“
CDR”
) thereof is selected from SEQ ID NOs;
15-28. - View Dependent Claims (7, 8, 9, 10, 11, 12)
- SOD1”
Specification