Lyophilization

• US 9,863,699 B2
• Filed: 06/09/2015
• Issued: 01/09/2018
• Est. Priority Date: 06/09/2014
• Status: Active Grant

• Current Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Original Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Inventors: Corbin, III, Frank, Hlavinka, Dennis J., Pareta, Rajesh, Hillam, Mark E.
• Primary Examiner(s): Gravini, Stephen M
• Application Number:
  US14/734,832
• Publication Number:
  US 20150354894A1
• Time in Patent Office: 945 Days
• Field of Search: 34284, 34287, 34296, 34 92
• CPC Class Codes: A01N 1/0252 Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
• CPC Class Codes: A01N 1/0263 Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
• CPC Class Codes: A01N 1/0284 Temperature processes, i.e. using a designated change in temperature over time
• CPC Class Codes: A01N 1/0289 Pressure processes, i.e. using a designated change in pressure over time
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/14 Details; Accessories therefor A61J7/00 takes precedence; openers B65D, B67B7/00
• CPC Class Codes: A61J 1/1468 Containers characterised by specific material properties
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61L 2/07 Steam
• CPC Class Codes: A61L 2/084 Visible light
• CPC Class Codes: A61L 2/085 Infrared radiation
• CPC Class Codes: A61L 2/088 using a photocatalyst or photosensitiser
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: A61L 2202/11 Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
• CPC Class Codes: A61L 2202/22 Blood or products thereof
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: A61M 1/0272 Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
• CPC Class Codes: A61M 1/0286 Handling a large number of blood product units, e.g. storage cabinets, blood bank administration
• CPC Class Codes: A61M 2202/0415 Plasma
• CPC Class Codes: F26B 5/06 the process involving freezing

Abstract

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

Claims

1. A container for lyophilizing, storing, and transfusing a blood component, the container comprising:

a first wall made from a porous material comprising a polymer, the first wall having a first permeability to water vapor;

a second wall attached to the first wall to define an interior volume of the container, wherein the second wall comprises a polymeric material and has a second permeability to water vapor that is lower than the first permeability to water vapor;

the interior volume of the container holding a blood component for lyophilization; and

a third wall positioned adjacent the first wall to provide protection for the first wall, wherein the third wall has a third permeability to water vapor that is greater than or equal to the first permeability to water vapor.

2. The container of claim 1, wherein the first wall is water resistant.

3. The container of claim 2, wherein the first permeability to water vapor comprises at least 15 perms.

4. The container of claim 3, wherein the first wall has a water resistance of greater than 100 cm.

5. The container of claim 1, further comprising a port connector between the first wall and the second wall.

6. The container of claim 1, wherein the blood component comprises human plasma and after a lyophilization process, the interior volume of the container comprises lyophilized human plasma.