Methods for comprehensive Fourier domain optical coherence tomography (FDOCT)

• US 9,867,536 B2
• Filed: 02/12/2016
• Issued: 01/16/2018
• Est. Priority Date: 10/23/2009
• Status: Active Grant

• Current Assignee: Leica Microsystems NC, Inc. (Danaher Corporation)
• Original Assignee: Bioptigen, Inc. (Danaher Corporation)
• Inventors: Izatt, Joseph A., Buckland, Eric L., Bower, Bradley A., Hart, Robert H.
• Primary Examiner(s): DECENZO, SHAWN H
• Application Number:
  US15/042,592
• Publication Number:
  US 20160166144A1
• Time in Patent Office: 704 Days
• Field of Search: None
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/117 for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
• CPC Class Codes: A61B 3/1225 using coherent radiation
• CPC Class Codes: G01B 9/0201 using temporal phase variation
• CPC Class Codes: G01B 9/02078 Caused by ambiguity
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.

Claims

1. A method for imaging a whole eye using an optical coherence tomography system, the whole eye comprising an anterior segment anterior to a pupil and a posterior segment posterior to a pupil, the method comprising:

rapidly switching focal optics of a sample arm between at least two scanning modes in from about 1.0 ms to about 1.0 second,

wherein the at least two scanning modes comprise an anterior segment scanning mode and a posterior segment scanning mode;

wherein the sample arm comprises a fiber input, a collimating lens, a scanning mirror, and an objective lens assembly including optical elements arranged in at least two lens groups;

wherein one lens group is in a first position with respect to a second lens group of the objective lens assembly in the anterior segment scanning mode and in a second position in the posterior segment scanning mode; and

wherein the one lens group is translated by a distance equal to a focal length of the lens group in switching between the first position for anterior segment scanning and the second position for posterior segment scanning.

2. The method of claim 1, further comprising switching the focal optics between the at least two scanning modes without use of an external adapter.

3. The method of claim 1, further comprising rapidly switching a reference delay in a reference arm when the focal optics of the sample arm are switched between the at least two scanning modes.

4. The method of claim 3, further comprising splitting light from the reference arm of an interferometer into at least two separate paths.

5. The method of claim 4, further comprising presetting the at least two separate paths to an optical delay each corresponding to one of the at least two scanning modes.

6. The method of claim 5, wherein rapidly switching a reference delay comprises blocking all but a desired reference delay associated with a corresponding one of the at least two scanning modes.

7. A method for imaging structures of an anterior segment of an eye and posterior structures of the eye in at least two dimensions using an optical coherence tomography system, the method comprising:

switching focal optics in an optical path of a sample arm of the system between at least two scanning modes by changing relative positions of two or more optical elements within the optical path of the sample arm,

wherein the at least two scanning modes include a first scanning mode configured to focus on an anterior structure of the eye and a second scanning mode configured to pivot through a pupil of the eye prior to focusing on a posterior structure of the eye;

wherein the optical path of the sample arm comprises a fiber input, a collimating lens, a scanning mirror and an objective lens assembly including optical elements arranged in at least two lens groups;

wherein the at least two groups of the objective lens assembly are in a first relative position in the first scanning mode configured to focus on the anterior structure of the eye and a second relative position in the second scanning mode configured to pivot through the pupil of the eye prior to focusing on the posterior structure of the eye; and

wherein a distance between one pair of the lens groups is translated by a distance equal to a focal length of one of the lens groups to switch the system from scanning in the first scanning mode to image an anterior structure of the eye and scanning in the second scanning mode to image a posterior structure of the eye.

8. The method of claim 7, further comprising switching the focal optics between the at least two scanning modes without addition or removal of an optical element from the optical path of the sample arm.

9. The method of claim 8, wherein switching the focal optics further comprises switching the focal optics between modes within a time of from about 1.0 ms to about 1.0 s.

10. The method of claim 9, further comprising switching a reference delay in a reference arm when the focal optics of the sample arm are switched between the at least two scanning modes.

11. The method of claim 10, further comprising splitting light from the reference arm of an interferometer into at least two separate paths.

12. The method of claim 11, further comprising presetting the at least two separate paths to an optical delay each corresponding to a structure of an eye corresponding to one of the at least two scanning modes.

13. The method of claim 10, wherein switching a reference delay comprises a blocking all delays except a desired reference delay associated with a corresponding one of the at least two scanning modes.

14. A method for imaging a whole eye in an optical coherence tomography system, the method comprising:

switching focal optics included in a sample arm of the system between at least two scanning modes, wherein the at least two scanning modes comprise an anterior segment scanning mode and a retinal scanning mode and wherein the sample arm of the system in retinal scanning mode comprises a collimator, a two-axis scanning mirror assembly, and a scan lens assembly, an objective lens;

repositioning at least one movable lens to change an optical coherence tomography (OCT) scan beam from a collimated beam for imaging an emmetropic eye to one of a diverging beam for imaging a myopic eye and a converging beam for imaging a hyperopic eye;

modifying components within an optical pathway of the sample arm to switch the scanning mode between the retinal scanning mode and the anterior segment scanning mode; and

switching between two path delays in coordination with switching between the at least two scanning modes,

wherein a first path delay is configured to match an optical path length of the OCT scan beam in the retinal scanning mode and a second path delay is configured to match an optical path length of the OCT scan beam in anterior segment scanning mode;

wherein the sample arm of the system in the anterior segment scanning mode comprises a collimating lens, two two-axis scanning mirror assemblies, a scan lens, an objective lens and a curved mirror placed a focal length (f) away from a first of the two two-axis scanning mirror assemblies; and

wherein the method further comprises directing re-directed collimated light from a second of the two two-axis scanning mirror assemblies in a triangular pattern towards the curved mirror causing the optical path length of the system to be longer in the anterior segment scanning mode than in the retinal scanning mode.

15. The method of claim 14, further comprising repositioning the focal optics of the sample arm to reposition the at least one movable lens using a mechanical means for insertion of an additional lens assembly into the optical pathway of the sample min immediately proximal or immediately distal to the collimator to change the system from the retinal scanning mode to anterior segment scanning mode.

16. The method of claim 14, wherein switching a reference delay further comprises blocking all but an identified reference delay associated with a corresponding one of the at least two scanning modes.

17. A method for imaging a whole eye in an optical coherence tomography system, the method comprising:

switching focal optics included in a sample arm of the system between at least two scanning modes, wherein the at least two scanning modes comprise an anterior segment scanning mode and a retinal scanning mode and wherein the sample arm of the system in retinal scanning mode comprises a collimator, a two-axis scanning mirror assembly, and a scan lens assembly, an objective lens;

repositioning at least one movable lens to change an optical coherence tomography (OCT) scan beam from a collimated beam for imaging an emmetropic eye to one of a diverging beam for imaging a myopic eye and a converging beam for imaging a hyperopic eye;

modifying components within an optical pathway of the sample arm to switch the scanning mode between the retinal scanning mode and the anterior segment scanning mode; and

switching between two path delays in coordination with switching between the at least two scanning modes,

wherein a first path delay is configured to match an optical path length of the OCT scan beam in the retinal scanning mode and a second path delay is configured to match an optical path length of the OCT scan beam in anterior segment scanning mode;

wherein the sample arm of the system in the anterior segment scanning mode comprises a collimating lens, a two-axis scanning mirror assembly, a scan lens, an objective lens, a flat mirror and a concave mirror placed a focal length (f) away from the two-axis scanning mirror assembly; and

wherein the method further comprises deviating light incident on a two-dimensional scanner pair such that an incident collimated beam is directed into a separate path consisting of the flat mirror and the concave mirror.