Optical guided vacuum assisted biopsy device

• US 9,867,599 B2
• Filed: 10/16/2013
• Issued: 01/16/2018
• Est. Priority Date: 02/27/2013
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Hendriks, Bernardus Hendrikus Wilhelmus, Reich, Christian, Bierhoff, Waltherus Cornelis Jozef, Mueller, Manfred, Van Gaal, Franciscus Marinus Antonius Maria, Versleegers, Jozef Christiaan Mathieu, Pully, Vishnu Vardhan, Stoffelen, Sven
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US14/762,526
• Publication Number:
  US 20150359525A1
• Time in Patent Office: 1,553 Days
• CPC Class Codes: A61B 10/0041 Detection of breast cancer mammography by transillumination A61B5/0091, by X-rays A61B6/502, by ultrasonic means A61B8/0825
• CPC Class Codes: A61B 10/0275 with sample notch, e.g. on the side of inner stylet
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61B 2010/0225 for taking multiple samples
• CPC Class Codes: A61B 2010/045 Needles pointed biopsy devices with vacuum aspiration A61B10/0283
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00199 with a console, e.g. a control panel with a display
• CPC Class Codes: A61B 2017/008 Removal of tumors
• CPC Class Codes: A61B 2017/00907 for light
• CPC Class Codes: A61B 2017/320064 with tissue or sample retaining means
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6848 Needles

Abstract

An interventional device, e.g. a Vacuum Assisted Biopsy (VAB) needle, incorporating optical fibers such that biological tissue in a volume at a side of the interventional device can be substantially completely optically probed by optical spectroscopy. In a VAB embodiment, a plurality of optical fiber pairs connected to respective optical ports, are placed at opposite positions along the suction cavity, and they are readout subsequently allowing to make a map of the tissue properties along the place where the tissue will be cut by the VAB needle. Based on decision software in an optical console, it can be determined whether the tissue present in the cutting cavity is completely normal tissue or not, prior to actually performing the biopsy on the tissue. In this way a well defined end point for VAB is created. In one embodiment, the optical fibers are arranged in a wall structure of a thin sleeve which fits onto existing VAB needles, thus allowing the VAB needle to be upgraded with an optical probing capability.

Claims

1. An interventional device comprising

a needle structure arranged for being inserted into biological tissue, the needle structure having a cavity positioned to a side of the needle structure and

a plurality of optical fibers externally accessible in one end and connected to optical ports in their opposite end, wherein the optical ports are spatially distributed on surface portions of the needle structure on opposite sides of the cavity, in order to allow optical probing of biological tissue present in the cavity, upon application of an optical signal to one of the plurality of optical fibers at a first side of the cavity and detection of an optical response thereto at another one of the plurality of optical fibers at the opposite side of the cavity.

2. Interventional device comprising

a needle structure arranged for being inserted into biological tissue, the needle structure having a cavity positioned to a side of the needle structure and

a plurality of optical fibers externally accessible in one end and connected to optical ports in their opposite end, wherein the optical ports are spatially distributed on surface portions of the needle structure on opposite sides of the cavity, in order to allow optical probing of biological tissue present in the cavity, upon application of an optical signal to one of the plurality of optical fibers at a first side of the cavity and detection of an optical response thereto at another one of the plurality of optical fibers at the opposite side of the cavity,

wherein the needle structure comprises a sleeve with a wall forming the cavity as a hollow space, and wherein the plurality of optical fibers are arranged at least partly within a structure of the wall of the cavity.

3. Interventional device according to claim 2, wherein at least a first optical port is arranged at a surface part of the wall, so as to direct light outside the sleeve in a direction perpendicular to a longitudinal extension of the sleeve, upon application of an optical signal, and wherein at least a second optical port is arranged at another surface part of the wall, so as to allow receipt of an optical response to said light from biological tissue present in the cavity positioned to a side of the sleeve.

4. Interventional device according to claim 3, wherein said at least first optical port is connected to an optical fiber) arranged within a structure of the wall of the sleeve following at least a part of a helical pattern, so that a vector along said optical fiber points outside the sleeve at said at least first optical port.

5. Interventional device according to claim2, wherein the optical ports are spatially distributed so as to cover different longitudinal positions of the cavity.

6. Interventional device according to claim 2, comprising a biopsy device,

wherein the structure of the biopsy device is arranged for being inserted into biological tissue and for taking a biopt thereof, wherein the cavity is configured so that a part of the biological tissue can be sucked upon application of a negative pressure, wherein the needle structure comprises a hole through which the biopt can be sucked upon application of a negative pressure, and

wherein the optical ports are spatially distributed so as to cover different longitudinal positions of the cavity, in order to allow optical probing of biological tissue present in the cavity, upon application of an optical signal to one of the plurality of optical fibers and detection of an optical response thereto at another one of the plurality of optical fibers.

7. Interventional device according to claim 6, wherein a plurality of optical ports are positioned along the cavity so as to allow optical probing of a total volume of biological tissue present in the cavity.

8. Interventional device according to claim 2, wherein the optical fibers are arranged in a wall of an obturator of the needle structure, along an axis of rotation of the needle geometry.

9. Interventional device according to claim 2, wherein the optical ports are formed as respective openings in a wall of an obturator) of the needle structure.

10. Interventional device according to claim 2, wherein the optical ports are formed as openings sealed by one of:

an optically transparent resin, an optically scattering resin.

11. Interventional device according to claim 2, wherein a plurality of optical ports are arranged on a first straight line parallel with a longitudinal axis of the needle structure, and wherein a plurality of optical ports are arranged on a second straight line parallel with the first line.

12. Interventional device according to claim 2, comprising a console with at least one light source and a light detector, wherein the console is arranged for connection to the optical fibers, so as to allow emission of an optical signal from the light source to a first selection of the optical ports, and to allow receipt of light from a second selection of the optical ports.

13. Interventional device according to claim 2, comprising a console with at least one light source and a light detector, wherein the console is arranged for connection to the optical fibers, so as to allow emission of an optical signal from the light source to a first selection of the optical ports, and to allow receipt of light from a second selection of the optical ports,

wherein the console comprises a processor capable of determining respective measures of spectral contents of optical signals received from the second selection of the optical ports, and wherein the console is arranged to generate an output indicative of respective states of the biological tissue present at different longitudinal positions in the cavity of the needle structure accordingly.