Integrated cement delivery system for bone augmentation procedures and methods

• US 9,867,646 B2
• Filed: 12/02/2015
• Issued: 01/16/2018
• Est. Priority Date: 04/07/2006
• Status: Active Grant

• Current Assignee: Gamal Baroud
• Original Assignee: Gamal Baroud
• Inventors: Baroud, Gamal
• Primary Examiner(s): SEVILLA, CHRISTIAN ANTHONY
• Application Number:
  US14/956,866
• Publication Number:
  US 20160081732A1
• Time in Patent Office: 776 Days
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 17/8805 for introducing fluid filler into bone or extracting it A61B17/7097, A61B17/8833 take precedence
• CPC Class Codes: A61B 17/8811 characterised by the introducer tip, i.e. the part inserted into or onto the bone
• CPC Class Codes: A61B 17/8816 characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
• CPC Class Codes: A61B 17/8819 characterised by the introducer proximal part, e.g. cannula handle, or by parts which are inserted inside each other, e.g. stylet and cannula A61B17/8825 takes precedence
• CPC Class Codes: A61B 17/8822 characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
• CPC Class Codes: A61B 18/06 caused by chemical reaction , e.g. moxaburners
• CPC Class Codes: A61B 2010/0258 Marrow samples
• CPC Class Codes: A61B 2017/00685 Archimedes screw
• CPC Class Codes: A61B 2017/8844 Means for determining the viscosity of bone cement
• CPC Class Codes: A61B 2018/00565 Bone
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2090/032 pressure limiting, e.g. hydrostatic
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 2090/3916 Bone tissue
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2218/002 Irrigation
• CPC Class Codes: A61B 2218/007 Aspiration
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: A61B 5/150015 : Source of blood
• CPC Class Codes: A61B 5/150099 : by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150213 : Venting means
• CPC Class Codes: A61B 5/150389 : Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150503 : Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 90/37 : Surgical systems with images on a monitor during operation
• CPC Class Codes: A61B 90/50 : Supports for surgical instruments, e.g. articulated arms
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2230/0071 : spherical
• CPC Class Codes: A61L 24/08 : Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1456 : with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/14566 : with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/20 : Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/32 : Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: A61M 5/3286 : Needle tip design, e.g. for improved penetration
• CPC Class Codes: A61M 5/329 : characterised by features of the needle shaft
• CPC Class Codes: A61M 5/347 : rotatable, e.g. bayonet or screw A61M5/344 takes precedence
• CPC Class Codes: A61M 5/484 : Regulating injection pressure
• CPC Class Codes: A61M 5/488 : Limiting injection pressure
• CPC Class Codes: A61N 2005/1021 : Radioactive fluid
• CPC Class Codes: A61N 5/1007 : Arrangements or means for the introduction of sources into the body

Abstract

A method of harvesting bone marrow, including percutaneously introducing a multi-lumen cannula into a cancellous bone, applying suction through a first passage defined in a first lumen of the cannula, injecting a thick flowable material into the bone from a second passage in a second lumen of the cannula, extruding the thick flowable material through a distal end of the cannula into the cancellous bone in order to displace the bone marrow and other bone fluids, the suction applied through the first passage providing a hydraulic force guiding the displaced bone marrow and collecting the displaced bone marrow for a therapeutic or diagnostic purpose. A thick flowable material for use in harvesting bone marrow in the cancellous portion of a bone and a method for percutaneously preparing a bone with a multi-lumen cannula and an inflatable device are also discussed.

Claims

1. A method of harvesting bone marrow, comprising:

percutaneously introducing a multi-lumen cannula into a cancellous bone;

applying suction through a first passage defined in a first lumen of the cannula;

injecting a thick flowable material into the bone from a second passage in a second lumen of the cannula;

extruding the thick flowable material through a distal end of the cannula into the cancellous bone in order to displace the bone marrow and other bone fluids, the suction applied through the first passage providing a hydraulic force guiding the displaced bone marrow; and

collecting the displaced bone marrow for a therapeutic or diagnostic purpose.

2. The method as defined in claim 1, wherein the thick flowable material is a biocompatible medical gel.

3. The method as defined in claim 1, wherein the thick flowable material is a biocompatible gummy-like material with high extensibility.

4. The method as defined in claim 3, wherein the gummy-like material has a storage modulus higher 0.1 MPa when measured at room temperature using a rheometer oscillating at 5 Hz.

5. The method as defined in claim 4, wherein the gummy-like material is a medical gel.

6. The method as defined in claim 1, wherein the thick flowable material has a flow behaviour similar to that of petroleum jelly.

7. The method of harvesting bone marrow as defined in claim 1, wherein the thick flowable material is in the form of granular material.

8. The method of harvesting bone marrow as defined in claim 3, wherein the thick flowable material has a yield stress above 100 kPa.

9. The method of harvesting bone marrow as defined in claim 1, wherein the thick flowable material has the following properties:

the material forms a solid body at room temperature while below a yield stress of the material;

the material is flowable when mechanical pressure causing a stress exceeding the yield stress is applied thereon; and

the material becomes a solid body when the mechanical pressure is removed.

10. The method of harvesting bone marrow as defined in claim 9, wherein the material has a yield stress above 100 kPa.

11. The method of harvesting bone marrow as defined in claim 9, wherein the material is a medical gel having a level of extensibility allowing the thick flowable material to be stretched up to 3 times an original length thereof without fracturing or disintegration.

12. The method of harvesting bone marrow as defined in claim 9, wherein the material has a flow behaviour similar to that of petroleum jelly, or is a nano-structured cellulose gel.

13. The method of harvesting bone marrow as defined in claim 9, wherein the material is in the form of granular material.

14. The method of harvesting bone marrow as defined in claim 13, wherein a grain size of the granular material is at least 1 μ

m and at most is 6 mm.