Multi-chamber cellular mixing and delivery system and method

• US 9,867,788 B2
• Filed: 07/09/2010
• Issued: 01/16/2018
• Est. Priority Date: 07/09/2009
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Schroeder, Tania M., Sautner, Natalie Ann
• Primary Examiner(s): Landry, II, Gerald
• Application Number:
  US13/382,703
• Publication Number:
  US 20120101472A1
• Time in Patent Office: 2,748 Days
• Field of Search: 604 82, 604 83, 604 84, 604 85, 604 89, 604187, 604190, 604191, 604500, 604506, 604518, 604519, 604522, 606 79, 606184, 606186
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61M 2210/167 Penis
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491

Abstract

A multi-chamber injection and treatment system includes a first chamber, a second chamber, a mixing element, and a needle portion. The first chamber is generally adapted to receive and advance various cells, while the second chamber is adapted to receive and advance adipose tissue, and can blend or reduce the size of the adipose tissue. The mixing element combines the constituents of the chambers and is in communication with the needle portion for driving the cellular mixture into a target tissue site, such as the mid-corpora of the male penis.

Claims

1. A multi-chamber mixing and injection system, the system comprising:

a first chamber adapted to receive a cellular matter;

a second chamber adapted to receive adipose tissue;

a tissue reduction element in fluid communication with the second chamber, the tissue reduction element including a blade assembly moveable to produce a reduced adipose tissue and push the reduced adipose tissue distally;

an mixing element in fluid communication with a distal outlet port of the first chamber and a distal outlet port of the second chamber, the mixing element including a freely rotatable member to mix the cellular matter and the reduced adipose tissue into a cellular mixture; and

an injection element on fluid communication with the mixing element.

2. The system of claim 1, further comprising a filter element adapted to receive the reduced adipose tissue for filtering adipose tissue of a predetermined size.

3. The system of claim 2, wherein the filter element excludes reduced adipose tissue particles greater than about 1 mm in size.

4. The system of claim 1, wherein the injection element is a needle.

5. The system of claim 4, wherein the needle is of a predetermined length to promote insertion into the mid-corpora of a male penis.

6. The system of claim 5, further comprising an adjustable stop element operably coupled to the needle for adjusting an insertion length of the needle.

7. The system of claim 1, wherein the blade assembly comprises a plurality of rotating blades.

8. The system of claim 1, wherein the blade assembly is drivable along a plurality of the second chamber.

9. The system of claim 1, wherein the blade assembly is operably coupled to a distal end of a rotatable drive shaft.

10. The system of claim 9, wherein a proximal end of the drive shaft is operably coupled to a drive motor for rotating the drive shaft.

11. The system of claim 9, wherein a proximal end of the drive shaft is operably coupled to a handle member for manual rotation of the drive shaft.

12. The system of claim 1, further comprising a first plunger device moveable to push the cellular matter distally through the first chamber.

13. The system of claim 12, wherein the plunger device and the blade assembly are independently operable.

14. The system of claim 12, wherein the plunger device and the blade assembly are operable to push the cellular matter and the reduced adipose tissue simultaneously.

15. The system of claim 1, wherein the freely rotatable member of the mixing element comprises a rotatable propeller member.

16. The system of claim 1, wherein the freely rotatable member of the mixing element comprises a rotatable paddle member.

17. The system of claim 1, wherein the mixing element comprises a first spray nozzle for creating a stream of the cellular matter and a second spray nozzle for creating a stream of the reduced adipose tissue.

18. A method of mixing a cellular mixture, the method comprising:

filling a first chamber with a cellular matter and a second chamber with an adipose tissue, the second chamber including a tissue reduction element in fluid communication therewith, the tissue reduction element including a blade assembly;

passing the cellular matter distally through the first chamber;

moving the blade assembly to produce a reduced adipose tissue and push the reduced adipose tissue distally through the second chamber; and

operating a freely rotatable member of a mixing element in fluid communication with the first and second chambers to mix the cellular matter and the reduced adipose tissue.

19. The method of claim 18, wherein moving the blade assembly comprises driving the blade assembly along a plurality of threads within the second chamber.

20. A multi-chamber mixing and injection system, comprising:

a first chamber adapted to receive a cellular matter, the first chamber having a first longitudinal axis;

a second chamber adapted to receive an adipose tissue, the second chamber having a second longitudinal axis;

a plunger device for advancing the cellular matte through the first chamber along the first longitudinal axis;

a tissue reduction element in fluid communication with the second chamber, the tissue reduction element including a blade assembly moveable to produce a reduced adipose tissue and push the reduced adipose tissue through the second chamber along the second longitudinal axis;

a mixing element in fluid communication with the first chamber and the second chamber, the mixing element including a freely rotatable member to mix the cellular matter and the reduced adipose tissue into a cellular mixture; and

an injection element in fluid communication with the mixing element.

21. The system of claim 20, wherein the first longitudinal axis is parallel with the second longitudinal axis.