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Cured oil-hydrogel biomaterial compositions for controlled drug delivery

  • US 9,867,880 B2
  • Filed: 03/15/2013
  • Issued: 01/16/2018
  • Est. Priority Date: 06/13/2012
  • Status: Active Grant
First Claim
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1. A coating material coating a medical device, comprising:

  • a biomaterial layer comprising a biomaterial, wherein the biomaterial comprises fatty acids cross-linked to each other; and

    a fixating material layer comprising a fixating material, wherein the fixating material comprises material selected from the group consisting of sodium carboxymethylcellulose (Na—

    CMC), poly(ethylene glycol), poly(ethylene oxide), poly(HEMA), poly(N-vinyl pyrrolidone), poly(acrylic acid), carboxymethyl cellulose (CMC), and chitosan, and wherein the fixating material layer is disposed on an outer surface of the biomaterial layer relative to the medical device, and the biomaterial protonates the fixating material so as to alter a drug eluting property of the fixating material;

    wherein the fixating material layer comprises one or more therapeutic agents; and

    wherein the coating material effects controlled delivery in a patient of the one or more therapeutic agents from the coating material based on at least the altered drug eluting property of the fixating material.

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