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Disposable bioreactor system

  • US 9,868,095 B2
  • Filed: 01/10/2008
  • Issued: 01/16/2018
  • Est. Priority Date: 05/02/2007
  • Status: Active Grant
First Claim
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1. An apparatus comprising:

  • (a) a hollow toroidal one-piece polymeric bioreactor vessel comprising at least one port configured to receive at least one pre-inserted and pre-calibrated sensor to monitor a bioprocess carried out in said hollow toroidal one-piece polymeric bioreactor vessel; and

    (b) a drive configured to move the hollow toroidal one-piece polymeric bioreactor vessel such that there is build-up of a resonant frequency traveling wave of fluid orbiting in one direction in an interior of the hollow toroidal one-piece polymeric vessel when a particular amplitude and orbital speed is imparted to said hollow toroidal one-piece polymeric bioreactor vessel,wherein the resonant frequency depends on the size and shape of the hollow toroidal one-piece polymeric bioreactor vessel, andwherein at least a portion of an inner surface of said hollow toroidal one-piece polymeric bioreactor vessel is textured with a plurality of upstanding protuberances and said hollow toroidal one-piece polymeric bioreactor vessel includes at least one exit port for the removal of gaseous by-products.

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