Multispectral measurement for improved biological signal acquisition
First Claim
1. A functional near infrared (fNIR) system comprising:
- first, second, third, and fourth photo emitters;
at least one photo detector; and
at least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to;
(a) emit first photo energy at first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a first time period, (b) emit second photo energy at the first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a second time period, (c) determine first, second, third, and fourth optical density changes based on emitting the first and second photo energies;
(d) determine a first change in a first chromophore concentration and a second change in a second chromophore concentration based on the determined first, second, third, and fourth optical density changes;
(e) determine first, second, third, and fourth absorption values based on determining the first and second changes in the first and second chromophores;
(f) fit the first, second, third, and fourth absorption values to first and second absorption spectra datasets corresponding to the first and second chromophores; and
(g) determine at least one confidence level based on fitting the first, second, third, and fourth absorption values to first and second absorption spectra datasets.
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Accused Products
Abstract
An embodiment includes a functional near infrared (fNIR) system comprising: first, second, and third light emitting diodes (LED) and a photo detector; and at least one storage medium having instructions stored thereon for causing the system to: (a) emit photo energy at first, second, and third wavelengths from the first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy; and (c) determine and fit first, second, and third absorption values to a first absorption spectra curve based on the determined changes in first and second chromophore concentrations. Other embodiments are described herein.
9 Citations
24 Claims
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1. A functional near infrared (fNIR) system comprising:
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first, second, third, and fourth photo emitters; at least one photo detector; and at least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to;
(a) emit first photo energy at first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a first time period, (b) emit second photo energy at the first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a second time period, (c) determine first, second, third, and fourth optical density changes based on emitting the first and second photo energies;
(d) determine a first change in a first chromophore concentration and a second change in a second chromophore concentration based on the determined first, second, third, and fourth optical density changes;
(e) determine first, second, third, and fourth absorption values based on determining the first and second changes in the first and second chromophores;
(f) fit the first, second, third, and fourth absorption values to first and second absorption spectra datasets corresponding to the first and second chromophores; and
(g) determine at least one confidence level based on fitting the first, second, third, and fourth absorption values to first and second absorption spectra datasets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A functional near infrared (fNIR) system comprising:
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first, second, and third light emitting diodes (LED) and a photo detector; and at least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to;
(a) emit photo energy at first, second, and third wavelengths from the first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy; and
(c) determine and fit first, second, and third absorption values to a first absorption spectra curve in response to determining changes in the first and second chromophore concentrations. - View Dependent Claims (17, 18, 19, 20, 21)
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22. At least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to:
(a) emit photo energy at first, second, and third wavelengths from first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy;
(c) determine and fit first, second, and third absorption values to at least one of first and second absorption spectra curves; and
(d) determine a confidence level based on fitting the first, second, and third absorption values to at least one of the first and second absorption spectra curves.- View Dependent Claims (23, 24)
Specification