Multispectral measurement for improved biological signal acquisition

• US 9,872,621 B2
• Filed: 12/17/2014
• Issued: 01/23/2018
• Est. Priority Date: 12/17/2014
• Status: Expired due to Fees

• Current Assignee: Intel Corporation
• Original Assignee: Intel Corporation
• Inventors: Falconer, Maynard C., Beltman, Willem M.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US14/572,938
• Publication Number:
  US 20160174843A1
• Time in Patent Office: 1,133 Days
• CPC Class Codes: A61B 2560/0475 Special features of memory means, e.g. removable memory cards
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2576/026 for the brain
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: G16H 30/40 for processing medical images, e.g. editing

Abstract

An embodiment includes a functional near infrared (fNIR) system comprising: first, second, and third light emitting diodes (LED) and a photo detector; and at least one storage medium having instructions stored thereon for causing the system to: (a) emit photo energy at first, second, and third wavelengths from the first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy; and (c) determine and fit first, second, and third absorption values to a first absorption spectra curve based on the determined changes in first and second chromophore concentrations. Other embodiments are described herein.

Claims

1. A functional near infrared (fNIR) system comprising:

first, second, third, and fourth photo emitters;

at least one photo detector; and

at least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to;

(a) emit first photo energy at first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a first time period, (b) emit second photo energy at the first, second, third, and fourth wavelengths from the first, second, third, and fourth photo emitters during a second time period, (c) determine first, second, third, and fourth optical density changes based on emitting the first and second photo energies;

(d) determine a first change in a first chromophore concentration and a second change in a second chromophore concentration based on the determined first, second, third, and fourth optical density changes;

(e) determine first, second, third, and fourth absorption values based on determining the first and second changes in the first and second chromophores;

(f) fit the first, second, third, and fourth absorption values to first and second absorption spectra datasets corresponding to the first and second chromophores; and

(g) determine at least one confidence level based on fitting the first, second, third, and fourth absorption values to first and second absorption spectra datasets.

2. The system of claim 1, wherein (a) the first, second, third, and fourth wavelengths are unequal to each other, and (b) the first and second wavelengths are between 650 nm and 800 nm and the third and fourth wavelengths are between 800 nm and 950 nm.

3. The system of claim 2, wherein the first and second absorption spectra datasets correspond to first and second absorption spectra curves.

4. The system of claim 3, wherein the first wavelength corresponds to a location at or less than an inflection point for the first absorption spectra curve and the second wavelength corresponds to an additional location greater than the inflection point.

5. The system of claim 4, wherein:

the first chromophore is one of hemoglobin and oxygenated hemoglobin and the second chromophore is another of hemoglobin and oxygenated hemoglobin; and

at least one of the first, second, third, and fourth wavelengths is greater than 900 nm.

6. The system of claim 1, wherein the first, second, third, and fourth photo emitters include light emitting diodes (LEDs).

7. The system of claim 1, wherein the instructions cause the system to determine a first confidence level corresponding to fitting the first, second, third, and fourth absorption values to the first absorption spectra dataset and a second confidence level corresponding to fitting the first, second, third, and fourth absorption values to the second absorption spectra dataset.

8. The system of claim 1, wherein the instructions cause the system to determine a first confidence level corresponding to fitting the first and second absorption values to the first absorption spectra dataset and fitting the third and fourth absorption values to the second absorption spectra dataset.

9. The system of claim 1, wherein the instructions cause the system to determine a first confidence level corresponding to fitting the first, second, third, and fourth absorption values to the first and second absorption spectra datasets.

10. The system of claim 9, wherein the first confidence level positively corresponds to when the first and second absorption values fit better to the first absorption spectra dataset than the second absorption spectra dataset and when the third and fourth absorption values fit better to the second absorption spectra dataset than the first absorption spectra dataset.

11. The system of claim 10, wherein the first confidence level negatively corresponds to when the first, second, third, and fourth absorption values fit better to the first absorption spectra dataset than the second absorption spectra dataset.

12. The system of claim 1, wherein the first, second, third, and fourth photo emitters are all generally equidistant from the at least one photo detector.

13. The system of claim 1 comprising:

fifth and sixth photo emitters;

wherein the instructions cause the system to (a) emit the first photo energy at fifth and sixth wavelengths from the fifth and sixth photo emitters during the first time period, (b) emit the second photo energy at the fifth and sixth wavelengths from the fifth and sixth photo emitters during the second time period, (c) determine fifth and sixth optical density changes based on emitting the first and second photo energies;

(d) determine the first change in the first chromophore and the second change in the second chromophore based on the determined fifth and sixth optical density changes;

(e) determine fifth and sixth absorption values based on determining the first and second changes in the first and second chromophores;

(f) fitting the fifth and sixth absorption values to the first and second absorption spectra datasets; and

(g) determine the at least one confidence level based on fitting the fifth and sixth absorption values to the first and second absorption spectra datasets.

14. The system of claim 1, wherein the instructions cause the system to determine a cognitive load based on the determined first and second changes in the first and second chromophores.

15. The system of claim 1, wherein the instructions cause the system to determine, via an overdetermined system, the first and second changes in the first and second chromophore concentrations based on the determined first, second, third, and fourth optical density changes.

16. A functional near infrared (fNIR) system comprising:

first, second, and third light emitting diodes (LED) and a photo detector; and

at least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to;

(a) emit photo energy at first, second, and third wavelengths from the first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy; and

(c) determine and fit first, second, and third absorption values to a first absorption spectra curve in response to determining changes in the first and second chromophore concentrations.

17. The system of claim 16, wherein (a) the first, second, and third wavelengths are unequal to each other, and (b) the first and second wavelengths are between 650 nm and 800 nm and the third wavelength is between 800 nm and 950 nm.

18. The system of claim 17, wherein the first wavelength corresponds to a location at or less than an inflection point for the first absorption spectra curve and the second wavelength corresponds to an additional location greater than the inflection point.

19. The system of claim 16, wherein the instructions cause the system to determine a confidence level based on fitting the first, second, and third absorption values to the first absorption spectra curve.

20. The system of claim 16, wherein the instructions cause the system to determine a confidence level based on fitting the first, second, and third absorption values to the first and second absorption spectra curves.

21. The system of claim 20, wherein the confidence level positively corresponds to when the first and second absorption values fit better to the first absorption spectra curve than the second absorption spectra curve and when the third absorption values fits better to the second absorption spectra curve than the first absorption spectra curve.

22. At least one non-transitory storage medium having executable instructions stored thereon that, when executed, cause a processor of the system to:

(a) emit photo energy at first, second, and third wavelengths from first, second, and third LEDs during first and second time periods, (b) determine first, second, and third optical density changes and changes in first and second chromophore concentrations based on the emitted photo energy;

(c) determine and fit first, second, and third absorption values to at least one of first and second absorption spectra curves; and

(d) determine a confidence level based on fitting the first, second, and third absorption values to at least one of the first and second absorption spectra curves.

23. The at least one medium of claim 22, wherein (a) the first, second, and third wavelengths are unequal to each other, and (b) the first and second wavelengths are between 650 nm and 800 nm and the third wavelength is between 800 nm and 950 nm.

24. The at least one medium of claim 23, wherein the first wavelength corresponds to a location at or less than an inflection point for the first absorption spectra curve and the second wavelength corresponds to an additional location greater than the inflection point.