Energy delivery systems and uses thereof

• US 9,872,729 B2
• Filed: 09/28/2015
• Issued: 01/23/2018
• Est. Priority Date: 05/03/2010
• Status: Active Grant

• Current Assignee: Neuwave Medical, Inc. (Johnson & Johnson)
• Original Assignee: Neuwave Medical, Inc. (Johnson & Johnson)
• Inventors: van der Weide, Daniel Warren, Lee, Jr., Fred T., Brace, Christopher Lee, Schefelker, Richard W., King, Laura G., Thom, Mark, Thiel, Matthew
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US14/867,986
• Publication Number:
  US 20160015453A1
• Time in Patent Office: 848 Days
• Field of Search: 606 33, 606 47, 600424, 600564
• CPC Class Codes: A61B 1/0051 with controlled bending of insertion part
• CPC Class Codes: A61B 17/320068 using mechanical vibrations, e.g. ultrasonic A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745
• CPC Class Codes: A61B 18/1487 Trocar-like, i.e. devices producing an enlarged transcutaneous opening
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/320069 for ablating tissue
• CPC Class Codes: A61B 2017/32007 with suction or vacuum means
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00071 Electrical conductivity
• CPC Class Codes: A61B 2018/00279 deployable
• CPC Class Codes: A61B 2018/00285 Balloons
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00744 Fluid flow
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/183 characterised by the type of antenna
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61B 2018/1892 Details of electrical isolations of the antenna
• CPC Class Codes: A61B 2034/2059 Mechanical position encoders
• CPC Class Codes: A61B 2090/374 : NMR or MRI
• CPC Class Codes: A61B 2090/3762 : using computed tomography systems [CT]
• CPC Class Codes: A61M 2025/0004 : having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0681 : Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/0021 : characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/0105 : Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61M 25/0133 : Tip steering devices
• CPC Class Codes: A61M 25/0136 : Handles therefor
• CPC Class Codes: A61M 25/0147 : with movable mechanical means, e.g. pull wires

Abstract

The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.

Claims

1. A method of treating a peripheral lung tissue region in a subject, comprising

steering a microwave energy delivery device through the subject'"'"'s lung and positioning the microwave energy delivery device at a target peripheral lung tissue region, and ablating the target peripheral lung tissue region with energy from the microwave energy delivery device,

wherein the steering is through the subject'"'"'s mouth, through the subject'"'"'s trachea, and through the subject'"'"'s lung,

wherein the microwave energy delivery device is of sufficient length to extend from the mouth of a human subject, through the trachea of the human subject, into the lung of the human subject and to the peripheral lung of the human subject;

wherein the diameter of the microwave energy delivery device is approximately 2 mm or less;

wherein the microwave energy delivery device is flexible;

wherein the microwave energy delivery device comprises an inner conductor, an outer conductor, and a stylet tip,

the inner conductor is a conductor of microwave energy,

the outer conductor is a conductor of microwave energy,

the inner conductor having a proximal end and a distal end,

the outer conductor having a proximal end and a distal end,

the stylet tip having a proximal end and a distal end,

the stylet tip attached at the distal end of the microwave energy delivery device;

wherein the microwave energy delivery device has therein one or more coolant channels for circulating and recirculating coolant, wherein the one or more coolant channels does not extend to the distal end of the stylet tip;

wherein the microwave energy delivery device has thereon a temperature sensor.

2. The method of claim 1, wherein the steering comprises

advancing a hollow primary catheter having a hollow channel catheter therein through the subject'"'"'s mouth, through the subject'"'"'s trachea, and through the subject'"'"'s lung until further advance is constrained by the diameter of the hollow primary catheter, wherein the hollow channel catheter has therein a steerable navigation catheter,

advancing the hollow channel catheter having the steerable navigation catheter therein beyond the distal end of the hollow primary catheter and extending the hollow channel catheter having the steerable navigation catheter therein through the subject'"'"'s lung and to the target peripheral lung tissue region,

withdrawing the steerable navigation catheter from the hollow channel catheter,

inserting the microwave energy delivery device through the hollow channel catheter such that it is positioned at the target peripheral lung tissue region.

3. The method of claim 2,

wherein advancing the hollow channel catheter having the steerable navigation catheter therein beyond the distal end of the hollow primary catheter and extending the hollow channel catheter having the steerable navigation catheter therein through the subject'"'"'s lung comprises extending the hollow channel catheter having the steerable navigation catheter therein through one or more of primary bronchial tissue, secondary bronchial tissue, tertiary bronchial tissue, and bronchiole tissue.

4. The method of claim 2, wherein the steerable navigation catheter controls the advancing.

5. The method of claim 1, wherein the microwave energy delivery device comprises a braided material.

6. The method of claim 1, wherein ablating the target peripheral lung tissue region with energy from the microwave energy delivery device is controlled with a processor.

7. The method of claim 1, wherein the microwave energy delivery device is in electrical communication with an energy power supply.

8. The method of claim 1, wherein the inner conductor is hollow.

9. The method of claim 1, wherein a dielectric material is positioned between the inner conductor and the outer conductor.

10. The method of claim 1, wherein the inner conductor and the outer conductor comprise air channels.

11. The method of claim 1, wherein the target peripheral lung tissue region comprises lung nodule tissue.

12. The method of claim 1, wherein the target peripheral lung tissue region comprises lung tumor tissue.

13. The method of claim 1, wherein the target peripheral lung tissue region comprises lung lesion tissue.

14. The method of claim 1, wherein the target peripheral lung tissue region comprises cancerous tissue.

15. The method of claim 1, wherein one or more stabilization and/or anchoring mechanisms are used to secure one or more of the hollow primary catheter, the hollow channel catheter, the steerable navigation catheter, and the microwave energy delivery device at a desired tissue region.

16. The method of claim 15, where the desired tissue region is the target peripheral lung tissue region.

17. The method of claim 1, wherein the microwave energy delivery device is configured to detect an undesired rise in temperature within the microwave energy delivery device and automatically or manually reduce such an undesired temperature rise through flowing of coolant through the one or more coolant channels.

18. The method of claim 1, wherein the microwave energy delivery device is a triaxial microwave probe.

19. The method of claim 18, wherein the triaxial microwave probe comprises optimized tuning capabilities to reduce reflective heat loss.

20. The method of claim 18, wherein the triaxial antenna comprises an inner conductor, a dielectric material, and an outer conductor, wherein the dielectric material is between the inner conductor and the outer conductor.