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Compositions and methods for the reduction or prevention of hepatic steatosis

  • US 9,872,844 B2
  • Filed: 09/02/2015
  • Issued: 01/23/2018
  • Est. Priority Date: 02/27/2014
  • Status: Active Grant
First Claim
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1. A method of reducing non-alcoholic steatohepatitis (NASH) in a subject in need thereof, comprising administering to the subject a composition comprising:

  • a) an amount of leucine in the form of a free amino acid and/or metabolite thereof;

    b) an amount of metformin; and

    c) an amount of sildenafil;

    wherein the amount of component (a) administered to the subject is about 0.25-3 g/day of leucine in the form of a free amino acid, and/or about 0.2-3 g/day of leucine metabolite;

    wherein the amount of component (b) administered to the subject is about 10-1000 mg/day of metformin;

    wherein the amount of component (c) administered to the subject is about 0.05-100 mg/day of sildenafil; and

    wherein components (a), (b), and (c) are co-administered to the subject simultaneously as a single composition or sequentially.

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