Renal therapy system having pump reversing fluid control

• US 9,872,950 B2
• Filed: 06/30/2015
• Issued: 01/23/2018
• Est. Priority Date: 11/05/2003
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Kelly, Thomas, Childers, Robert W., Busby, Don, Roger, Rodolfo, El Sayyid, Waleed Mutasem, Din, Shahid
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US14/754,856
• Publication Number:
  US 20150297816A1
• Time in Patent Office: 938 Days
• Field of Search: 604 401- 616
• CPC Class Codes: A61M 1/1522 the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1563 Details of incorporated filters
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1629 with integral heat exchanger
• CPC Class Codes: A61M 1/1633 with more than one dialyser unit
• CPC Class Codes: A61M 1/1635 with volume chamber balancing devices between used and fresh dialysis fluid
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/167 Flexible packaging for solid concentrates
• CPC Class Codes: A61M 1/1672 : using membrane filters, e.g. for sterilising the dialysate
• CPC Class Codes: A61M 1/1696 : with dialysate regeneration
• CPC Class Codes: A61M 1/267 : used for pumping
• CPC Class Codes: A61M 1/288 : Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 1/3401 : Cassettes therefor
• CPC Class Codes: A61M 1/341 : by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3417 : using distinct filters for dialysis and ultra-filtration
• CPC Class Codes: A61M 1/342 : Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3427 : back through the membrane, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3431 : upstream of the filter
• CPC Class Codes: A61M 1/3434 : with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 : downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3444 : in which the collected ultra-filtrate expels an equal volume of substitution fluid from a reservoir
• CPC Class Codes: A61M 1/3451 : the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 1/3458 : having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3465 : using dialysate as substitution fluid
• CPC Class Codes: A61M 1/3468 : using treated filtrate as substitution fluid
• CPC Class Codes: A61M 1/3472 : with treatment of the filtrate
• CPC Class Codes: A61M 1/3486 : Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3621 : Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/362223 : the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/36224 : with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 : with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 : at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362265 : Details of valves
• CPC Class Codes: A61M 1/3624 : Level detectors; Level control
• CPC Class Codes: A61M 1/3626 : Gas bubble detectors
• CPC Class Codes: A61M 1/3627 : Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 1/3643 : Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 : Mode of operation
• CPC Class Codes: A61M 1/3646 : Expelling the residual body fluid after use, e.g. back to the body
• CPC Class Codes: A61M 1/3647 : with recirculation of the priming solution
• CPC Class Codes: A61M 1/3649 : using dialysate as priming or rinsing liquid
• CPC Class Codes: A61M 1/365 : through membranes, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3652 : using gas, e.g. air
• CPC Class Codes: A61M 1/3656 : Monitoring patency or flow at connection sites; Detecting disconnections
• CPC Class Codes: A61M 2202/0413 : Blood
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/127 : with provisions for heating or cooling
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/15 : Detection of leaks
• CPC Class Codes: A61M 2205/18 : with alarm
• CPC Class Codes: A61M 2205/276 : preventing unwanted use
• CPC Class Codes: A61M 2205/3317 : Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 : PH measuring means
• CPC Class Codes: A61M 2205/3327 : Measuring
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3334 : Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3337 : Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/3344 : Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3393 : by weighing the reservoir
• CPC Class Codes: A61M 2205/3553 : remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 : Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 : with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/75 : with filters
• CPC Class Codes: A61M 60/113 : in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/258 : Piston pumps
• CPC Class Codes: A61M 60/279 : Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/37 : Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/508 : Electronic control means, e.g. for feedback regulation
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/851 : Valves

Abstract

A renal therapy system includes: a filter; an arterial blood flowpath in fluid communication with the filter; a venous blood flowpath in fluid communication with the filter; a renal therapy fluid flowpath in fluid communication with the filter; first and second renal therapy fluid pumps; a plurality of valve actuators; and a dialysis fluid cassette including a plurality of valve portions configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of second pump actuations.

Claims

1. A renal therapy system comprising:

a filter;

an arterial blood flowpath in fluid communication with the filter;

a venous blood flowpath in fluid communication with the filter;

a renal therapy fluid flowpath in fluid communication with the filter;

first and second renal therapy fluid pumps;

a plurality of valve actuators; and

a dialysis fluid cassette including a plurality of valve portions including at least one valve portion located upstream and downstream of the first renal therapy fluid pump or the second renal therapy fluid pump, the plurality of valve portions configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of second pump actuations.

2. The renal therapy system of claim 1, wherein the first and second renal therapy fluid pumps include first and second pump actuators, and wherein the dialysis cassette includes first and second pump portions operable with the first and second pump actuators.

3. The renal therapy system of claim 1, wherein the dialysis cassette includes the filter.

4. The renal therapy system of claim 1, wherein the dialysis cassette includes at least one of:

(i) a portion of the arterial blood flowpath;

(ii) a portion of the venous blood flowpath;

or (iii) a portion of the renal therapy fluid flowpath.

5. The renal therapy system of claim 1, wherein the number of first pump actuations equals the number of second pump actuations.

6. The renal therapy system of claim 1, wherein the plurality of valve portions operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the filter for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the filter for the number of second pump actuations.

7. The renal therapy system of claim 1, wherein the plurality of valve portions operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the arterial blood flowpath for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the arterial blood flowpath for the number of second pump actuations.

8. The renal therapy system of claim 1, wherein the plurality of valve portions operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the venous blood flowpath for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the venous blood flowpath for the number of second pump actuations.

9. The renal therapy system of claim 1, wherein the renal therapy fluid flowpath is a first renal therapy fluid flowpath, and which includes a second renal therapy fluid flowpath in fluid communication with the filter, wherein the plurality of valve portions operate with the plurality of valve actuators so that during (i) the second renal therapy fluid pump pulls effluent from the filter through the second renal therapy fluid flowpath, and during (ii) the first renal therapy fluid pump pulls effluent from the filter through the second renal therapy fluid flowpath.

10. A renal therapy system comprising:

a fluid supply;

a filter;

an arterial blood flowpath in fluid communication with the filter;

a venous blood flowpath in fluid communication with the filter;

an extracorporeal circuit including the filter, the arterial blood flowpath and the venous blood flowpath;

a renal therapy fluid flowpath in fluid communication with the filter;

first and second renal therapy fluid pumps;

a plurality of valve actuators; and

a dialysis fluid cassette including a first valve portion located between the fluid supply and an inlet of the first renal therapy fluid pump, a second valve portion located between the fluid supply and an inlet of the second renal therapy fluid pump, a third valve portion located between an outlet of the first renal therapy fluid pump and the extracorporeal circuit, a fourth valve portion located between an outlet of the second renal therapy fluid pump and the extracorporeal circuit, a fifth valve portion located between the extracorporeal circuit and the inlet of the first renal therapy fluid pump, a sixth valve portion located between the extracorporeal circuit and the inlet of the second renal therapy fluid pump, a seventh valve portion located between the outlet of the first renal therapy fluid pump and the fluid supply acting as a drain or a separate drain, and an eighth valve portion located between the outlet of the second renal therapy fluid pump and the fluid supply acting as a drain or a separate drain,

wherein each valve portion is configured to operate with one of the plurality of valve actuators.

11. The renal therapy system of claim 10, wherein the first and second renal therapy fluid pumps include first and second pump actuators, and wherein the dialysis cassette includes first and second pump portions operable with the first and second pump actuators.

12. The renal therapy system of claim 10, wherein the valve portions are configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath for a number of second pump actuations, and wherein the number of first pump actuations equals the number of second pump actuations.

13. The renal therapy system of claim 10, wherein the first and second pumps are membrane pumps or peristaltic pumps.

14. The renal therapy system of claim 10, wherein the valve portions are configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the filter for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the filter for a number of second pump actuations.

15. A renal therapy system comprising:

a filter;

an arterial blood flowpath in fluid communication with the filter;

a venous blood flowpath in fluid communication with the filter;

a first renal therapy fluid flowpath in fluid communication with the filter;

a second renal therapy fluid flowpath in fluid communication with the filter;

a first renal therapy fluid pump in fluid communication with the first and second renal therapy fluid flowpaths;

a second renal therapy fluid pump in fluid communication with the first and second renal therapy fluid flowpaths;

a first valve controlling a flow of renal therapy fluid through the first renal therapy fluid flowpath;

a second valve controlling a flow of renal therapy fluid through the second renal therapy fluid flowpath; and

a controller configured to operate the first and second valves so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath for a number of first pump actuations, (ii) the second renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath for a number of second pump actuations, (iii) the second renal therapy fluid pump pulls renal therapy fluid through the second renal therapy fluid flowpath during (i), and (iv) the first renal therapy fluid pump pulls renal therapy fluid through the second renal therapy fluid flowpath during (ii).

16. The renal therapy system of claim 15, wherein the second renal therapy fluid pump pulls renal therapy fluid through the second renal therapy fluid flowpath for the number of first pump actuations during (iii), and the first renal therapy fluid pump pulls renal therapy fluid through the second renal therapy fluid flowpath for the number of second pump actuations during (iv).

17. The renal therapy system of claim 15, wherein the number of first pump actuations equals the number of second pump actuations.

18. The renal therapy system of claim 15, wherein the controller operates the first and second valves so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the filter for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the filter for the number of second pump actuations.

19. The renal therapy system of claim 15, wherein the controller operates the first and second valves so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the arterial blood flowpath for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the arterial blood flowpath for the number of second pump actuations.

20. The renal therapy system of claim 15, wherein the controller operates the first and second valves so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the venous blood flowpath for the number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath to the venous blood flowpath for the number of second pump actuations.

21. A renal therapy system comprising:

a filter;

an arterial blood flowpath in fluid communication with the filter;

a venous blood flowpath in fluid communication with the filter;

a renal therapy fluid flowpath in fluid communication with the filter;

first and second renal therapy fluid pumps;

a plurality of valve actuators; and

a dialysis fluid cassette including a plurality of valve portions configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the arterial blood flowpath for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the renal therapy fluid flowpath to the arterial blood flowpath for a number of second pump actuations.

22. The renal therapy system of claim 21, wherein the number of first pump actuations equals the number of second pump actuations.

23. A renal therapy system comprising:

a filter;

an arterial blood flowpath in fluid communication with the filter;

a venous blood flowpath in fluid communication with the filter;

a first renal therapy fluid flowpath in fluid communication with the filter;

a second renal therapy fluid flowpath in fluid communication with the filter;

first and second renal therapy fluid pumps;

a plurality of valve actuators; and

a dialysis fluid cassette including a plurality of valve portions configured to operate with the plurality of valve actuators so that (i) the first renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath for a number of first pump actuations, and (ii) the second renal therapy fluid pump pumps renal therapy fluid through the first renal therapy fluid flowpath for a number of second pump actuations,

wherein during (i) the second renal therapy fluid pump pulls effluent from the filter through the second renal therapy fluid flowpath, and during (ii) the first renal therapy fluid pump pulls effluent from the filter through the second renal therapy fluid flowpath.

24. The renal therapy system of claim 23, wherein the number of first pump actuations equals the number of second pump actuations.