Electroosmotic convection-enhanced delivery system
First Claim
1. A method of administering a fluid to a tissue, comprising:
- inserting a blunt end of a distal portion of at least one fluid passage defined by a hollow fiber into a target tissue at a first position in a subject;
fluidically coupling a proximal portion of the at least one fluid passage defined by the hollow fiber to a fluid reservoir with a catheter, wherein a support rod is situated in lumens of the hollow fiber and the catheter;
placing a counter-electrode at a second subject position, wherein the fluid reservoir and the counter-electrode are operably connected to a current source;
applying a current to the fluid reservoir; and
allowing the fluid to be transported into the tissue in response to the applied current.
2 Assignments
0 Petitions
Accused Products
Abstract
Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.
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Citations
18 Claims
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1. A method of administering a fluid to a tissue, comprising:
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inserting a blunt end of a distal portion of at least one fluid passage defined by a hollow fiber into a target tissue at a first position in a subject; fluidically coupling a proximal portion of the at least one fluid passage defined by the hollow fiber to a fluid reservoir with a catheter, wherein a support rod is situated in lumens of the hollow fiber and the catheter; placing a counter-electrode at a second subject position, wherein the fluid reservoir and the counter-electrode are operably connected to a current source; applying a current to the fluid reservoir; and allowing the fluid to be transported into the tissue in response to the applied current. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification