Methods and devices for minimally-invasive delivery of radiation to the eye

• US 9,873,001 B2
• Filed: 09/15/2014
• Issued: 01/23/2018
• Est. Priority Date: 01/07/2008
• Status: Active Grant

• Current Assignee: Salutaris Medical Devices, Inc.
• Original Assignee: Salutaris Medical Devices, Inc.
• Inventors: Lutz, Wendell, Hamilton, Russell J., Cetas, Thomas C., Marsteller, Laurence J., Shriver, Timothy, Hyman, Samuel S.
• Primary Examiner(s): KUHLMAN, CATHERINE BURK
• Application Number:
  US14/486,401
• Publication Number:
  US 20160375267A1
• Time in Patent Office: 1,226 Days
• Field of Search: 600 8
• CPC Class Codes: A61B 1/06 with illuminating arrangements
• CPC Class Codes: A61F 9/00 Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand caps with means for protecting the eyes A42B1/018; visors for helmets A42B3/22; retractors A61B17/02; manipulators specially adapted for use in surgery A61B34/70; appliances to aid invalids to move about A61H3/00; exercisers for the eyes A61H5/00; eye baths A61H35/02; sunglasses or goggles having the same features as spectacles G02C
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61N 2005/1008 Apparatus for temporary insertion of sources, e.g. afterloaders
• CPC Class Codes: A61N 2005/1024 Seeds
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"

Abstract

Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.

Claims

1. An emanating source system, the emanating source system comprising an emanating source (401) that emits radiation and an attenuation zone (410) that reduces radiation emitted from the emanating source (401), the attenuation zone (410) is an indentation in a surface of the emanating source (401), wherein radiation is emitted from the emanating source (401) and the attenuation zone (410), and wherein the radiation emitted from the emanating source system provides a substantially uniform dose rate over a diameter of a target, the diameter being equivalent to a diameter of the emanating source.

2. The emanating source system of claim 1, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 10% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

3. The emanating source system of claim 1, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 20% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

4. The emanating source system of claim 1, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 50% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

5. The emanating source system of claim 1, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 80% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

6. The emanating source system of claim 1, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 90% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

7. The emanating source system of claim 1, wherein the emanating source is complexed with a carrier.

8. An emanating source system comprising an emanating source (401) that emits radiation and an attenuation zone (410) that reduces radiation emitted from the emanating source (401), the attenuation zone (410) is an indentation in a surface of the emanating source (401), wherein radiation is emitted from the emanating source (401) and the attenuation zone (410), wherein the radiation from the emanating source system provides a uniform dose rate over a diameter of a target, the diameter being equivalent to a diameter of the emanating source;

and a cannula system (100) comprising a distal portion (110) with a tip (112), wherein the emanating source (401) is disposed at a treatment position (118) in the tip (112).

9. The emanating source system of claim 8, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 10% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

10. The emanating source system of claim 8, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 20% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

11. The emanating source system of claim 8, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 50% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

12. The emanating source system of claim 8, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 80% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).

13. The emanating source system of claim 8, wherein a radiation dose emitted from the attenuation zone of the emanating source system is about 90% less than a radiation dose emitted from a portion of the emanating source (401) without the attenuation zone (410).