Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion

• US 9,873,118 B2
• Filed: 12/30/2011
• Issued: 01/23/2018
• Est. Priority Date: 12/30/2010
• Status: Active Grant

• Current Assignee: Abbott Point Of Care Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Point Of Care Incorporated (Abbott Laboratories)
• Inventors: Verrant, John A., Lalpuria, Niten V., Nikonorov, Igor, Unfricht, Darryn W., Ports, Benjamin, Wardlaw, Stephen C., Levine, Robert A., Holt, Robert, Hukari, Kyle
• Primary Examiner(s): Kwak, Dean
• Application Number:
  US13/341,618
• Publication Number:
  US 20120219457A1
• Time in Patent Office: 2,216 Days
• Field of Search: 422 681, 422502-505, 422507, 4352872, 435 721, 436180
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043

Abstract

A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

Claims

1. A biological fluid sample analysis cartridge, comprising:

a sample handling portion having a collection port, an initial channel, and a secondary channel in selective fluid communication with one another, and a fluid passage disposed within the sample handling portion, which fluid passage extends between an entry end intersecting with the secondary channel and an exit end defined in a surface of the sample handling portion; and

an analysis chamber portion that includes at least one analysis chamber defined by an upper panel having an interior surface and a base panel having an interior surface, wherein a lateral edge of the upper panel and a lateral edge of the base panel define a fill edge of the analysis chamber, and the interior surface of the upper panel and the interior surface of the base panel are separated a distance from one another that enables fluid sample contacting the fill edge to enter the analysis chamber by capillary action;

wherein the fill edge of the analysis chamber is separated from the fluid passage exit end by a void, which fill edge is therefore not connected to the fluid passage exit end, which void extends a traverse distance between the analysis chamber fill edge and the fluid passage exit end, which traverse distance is sized such that a self-contained body of the biological fluid sample can extend across the void and maintain contact between fluid exit end and the fill edge and pass between the fluid passage exit end and the fill edge by capillary action.

2. The cartridge of claim 1, wherein the sample handling portion and the analysis chamber portion are selectively attachable to and detachable from one another.

3. The cartridge of claim 1, wherein the secondary channel includes a flow impediment configured to cause the pressure within the secondary channel to increase when the self-contained body of the biological fluid sample moves through the secondary channel.

4. The cartridge of claim 1, wherein the secondary channel includes at least one dimension configured to cause a pressure difference between a leading edge and trailing edge of a bolus of liquid sample when the bolus moves through the secondary channel.

5. The cartridge of claim 1, wherein at least one pressure relief port is disposed in fluid communication with the secondary channel.

6. The cartridge of claim 5, wherein the fluid passage and the pressure relief port are in fluid communication with the secondary channel at the same axial position on the secondary channel.