Method for measuring temperature of biological sample, measuring device, and biosensor system

• US 9,874,537 B2
• Filed: 03/07/2017
• Issued: 01/23/2018
• Est. Priority Date: 01/30/2009
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: Fujiwara, Masaki
• Primary Examiner(s): Wallenhorst, Maureen
• Application Number:
  US15/451,754
• Publication Number:
  US 20170176374A1
• Time in Patent Office: 322 Days
• Field of Search: 436 63, 436 70, 436 95, 436147, 436149, 436150, 422 681, 422 73, 422 8201, 422 8202, 422 8212, 422503, 435 14, 435 29, 20440301, 205792
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: B01L 2200/147 Employing temperature sensors
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01K 7/00 Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat giving results other than momentary value of temperature G01K3/00 ; Power supply therefor, e.g. using thermoelectric elements
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/28 Electrolytic cell components
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.

Claims

1. A sensor chip comprising:

a glucose measurement system configured to measure a concentration of a glucose of a biological sample;

a temperature measurement system configured to measure a temperature of the biological sample;

a capillary configured to introduce the biological sample to the glucose measurement system and the temperature measurement system; and

a supply channel having a substantially T-shape, the supply channel being formed in the capillary,

wherein the glucose measurement system includes a first working electrode, a first counter electrode and a first reagent,

the temperature measurement system includes a second working electrode, a second counter electrode and a second reagent,

the second reagent includes a substance functioning as an electrolyte after being dissolved,

the glucose measurement system and the temperature measurement system are respectively disposed at different ends of the supply channel, and

(i) the first working electrode, the first counter electrode and the first reagent included in the glucose measurement system are disposed apart from (ii) the second working electrode, the second counter electrode and the second reagent included in the temperature measurement system.

2. The sensor chip according to claim 1,

wherein the first working electrode, the first counter electrode, the second working electrode and the second counter electrode are formed independently.

3. The sensor chip according to claim 1,

wherein the first reagent includes an oxidoreductase and a mediator.