Capacitive pumping and flow control

• US 9,874,559 B2
• Filed: 03/29/2011
• Issued: 01/23/2018
• Est. Priority Date: 11/24/2010
• Status: Active Grant

• Current Assignee: Inanovate, Inc.
• Original Assignee: Inanovate, Inc.
• Inventors: Nelson, James Curtis, Ure, David
• Primary Examiner(s): Crawford, Erik B
• Application Number:
  US13/989,642
• Publication Number:
  US 20130236335A1
• Time in Patent Office: 2,492 Days
• Field of Search: 4352879, 4352885, 4352886, 4352865, 4352873, 417395, 417480, 417390, 417478, 422504, 422 681, 422 81, 422 82, 92 96
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/123 Flexible; Elastomeric
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: F04B 43/0009 Special features
• CPC Class Codes: F04B 43/02 having plate-like flexible members, e.g. diaphragms F04B43/14 takes precedence
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures
• CPC Class Codes: G01N 33/557 using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction

Abstract

Embodiments of the invention relate generally to devices and methods for pumping and controlling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.

Claims

1. A pump system comprising:

a chamber having at least one elastic surface;

a first inlet valve in communication with and configured to deliver a first fluid to the chamber;

a second inlet valve in communication with and configured to deliver a second fluid to the chamber;

an outlet valve in communication with and configured to release either or both of the first or second fluid from the chamber; and

at least one assay surface within the chamber containing a capture agent for an analyte present in the first fluid and substantially absent from the second fluid,

wherein the chamber;

dilates in response to either or both of the first or second fluid exerting a pressure on the at least one elastic surface;

contains a quantity of either or both of the first or second fluid when so dilated; and

discharges the quantity of either or both of the first or second fluid through the opened outlet valve.

2. The pump system of claim 1, wherein the pressure includes a static head pressure exerted by a supply of the fluid in communication with either or both of the first inlet valve or the second inlet valve.

3. The pump system of claim 1, wherein the chamber increases in volume in a substantially linear manner in response to a substantially linear increase in the pressure.

4. The pump system of claim 1, wherein the at least one elastic surface includes at least one elastic material.

5. The pump system of claim 1, wherein the chamber has a zero-pressure volume and a dilated volume between about 101% and about 200% of the zero-pressure volume.

6. The pump system of claim 1, wherein the fluid includes a fluid selected from a group consisting of:

a liquid, a gas, a supercritical fluid, and mixtures and combinations thereof.

7. The pump system of claim 1, further comprising:

at least one additional outlet valve;

at least one additional chamber between and in communication with at least one of the first inlet valve or the second inlet valve and the at least one additional outlet valve, the at least one additional chamber having at least one additional elastic surface,

wherein the at least one additional chamber;

dilates in response to either or both of the first or second fluid exerting the pressure on the at least one additional elastic surface;

contains a second quantity of either or both of the first or second fluid when so dilated; and

discharges the second quantity of either or both of the first or second fluid through the opened at least one additional outlet valve,

wherein the second quantity of either or both of the first or second fluid is greater than the first quantity of either or both of the first or second fluid.

8. The pump system of claim 1, further comprising:

at least one additional outlet valve, wherein the chamber discharges the quantity of fluid through the outlet valve and the at least one additional outlet valve in substantially equal quantities.

9. The pump system of claim 1, wherein the chamber is adapted to receive the fluid through the first inlet valve and the second inlet valve in substantially equal quantities.

10. The pump system of claim 1, wherein the at least one assay surface binds to at least one biological molecule selected from a group consisting of:

a protein, a protein fragment, a peptide, an aptamer, an antibody, an auto-antibody, an antigen, a native antigen, a protein complex, a lipid, DNA, and RNA.

11. The pump system of claim 1, further comprising:

a sensor device for sensing one or more predetermined atoms, ions, molecules, elements, compounds, or compositions in either or both of the first or second fluid.

12. The pump system of claim 1, further comprising:

a micro reactor including catalyst particles for catalyzing a reaction with either or both of the first or second fluid.

13. The pump system of claim 1, wherein the chamber circulates either or both of the first or second fluid within a circulatory system of a mammal.

14. The pump system of claim 1, further comprising:

a plurality of flow channels formed as a matrix defining reaction chambers that are arranged in a plurality of fluidic columns and a plurality of fluidic rows,

wherein the outlet valve is in communication with at least one of the plurality of flow channels, such that the chamber is operable to discharge the quantity of either or both of the first or second fluid into the at least one of the plurality of flow channels.