Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
First Claim
1. A method for detecting glucose in a biological sample, comprising:
- utilizing at least one light generating structure configured to generate one or more light beams having a wavelength in a range between 800 nm and 1600 nm to strike a target area of a sample;
utilizing at least one photocurrent signal generating light detector positioned to receive light from the at least one light source and to generate an output photocurrent signal, having a time dependent current, which is indicative of the power of light detected;
receiving the output photocurrent signal from the at least one photocurrent signal generating light detector with a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and based on the received output photocurrent signal, wherein the at least one photocurrent signal generating light detector includes a preamplifier having a feedback resistor;
calculating the attenuance attributable to blood in a sample present in the target area with either a normalization factor or a ratio factor with the light absorbance change determining algorithm implemented processor;
eliminating effect of uncertainty caused by temperature dependent detector response of the at least one light detector with the light absorbance change determining algorithm implemented processor by calculating a standard deviation of a logarithm of the time dependent output current generated by the light power from the same target area of the biological sample;
determining a blood glucose level associated with a sample present in the target area with the light absorbance change determining algorithm implemented processor based on the calculated attenuance with the light absorbance change determining algorithm implemented processor; and
calculating at least one of a normalization factor Qi(C,T) based on a preamplifier output voltage Vi (t) of an ith preamplifier as a function of time, where σ
is standard deviation according to equation;
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Abstract
Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.
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Citations
3 Claims
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1. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light generating structure configured to generate one or more light beams having a wavelength in a range between 800 nm and 1600 nm to strike a target area of a sample; utilizing at least one photocurrent signal generating light detector positioned to receive light from the at least one light source and to generate an output photocurrent signal, having a time dependent current, which is indicative of the power of light detected; receiving the output photocurrent signal from the at least one photocurrent signal generating light detector with a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and based on the received output photocurrent signal, wherein the at least one photocurrent signal generating light detector includes a preamplifier having a feedback resistor; calculating the attenuance attributable to blood in a sample present in the target area with either a normalization factor or a ratio factor with the light absorbance change determining algorithm implemented processor; eliminating effect of uncertainty caused by temperature dependent detector response of the at least one light detector with the light absorbance change determining algorithm implemented processor by calculating a standard deviation of a logarithm of the time dependent output current generated by the light power from the same target area of the biological sample; determining a blood glucose level associated with a sample present in the target area with the light absorbance change determining algorithm implemented processor based on the calculated attenuance with the light absorbance change determining algorithm implemented processor; and calculating at least one of a normalization factor Qi(C,T) based on a preamplifier output voltage Vi (t) of an ith preamplifier as a function of time, where σ
is standard deviation according to equation; - View Dependent Claims (2)
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3. A method for detecting glucose in a biological sample, comprising:
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utilizing at least one light generating structure configured to generate one or more light beams having a wavelength in a range between 800 nm and 1600 nm to strike a target area of a sample; utilizing at least one photocurrent signal generating light detector positioned to receive light from the at least one light source and to generate an output photocurrent signal, having a time dependent current, which is indicative of the power of light detected; receiving the output photocurrent signal from the at least one photocurrent signal generating light detector with a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and based on the received output photocurrent signal, wherein the at least one photocurrent signal generating light detector includes a preamplifier having a feedback resistor; calculating the attenuance attributable to blood in a sample present in the target area with either a normalization factor or a ratio factor with the light absorbance change determining algorithm implemented processor; eliminating effect of uncertainty caused by temperature dependent detector response of the at least one light detector with the light absorbance change determining algorithm implemented processor by calculating a standard deviation of a logarithm of the time dependent output current generated by the light power from the same target area of the biological sample; determining a blood glucose level associated with a sample present in the target area with the light absorbance change determining algorithm implemented processor based on the calculated attenuance with the light absorbance change determining algorithm implemented processor; utilizing an analog-to-digital convertor having a digitized voltage output; and calculating at least one of a normalization factor Qi(C,T) based on an analog to digital convertor voltage output Δ
(ADC)i of an ith analog-to-digital convertor, where σ
is standard deviation according to the equation;
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Specification