Transdermal sampling and analysis device
First Claim
1. A transdermal sampling and analysis device comprising:
- a substrate having a first side;
a disruptor mounted on the first side of the substrate, wherein the disruptor has a resistance of about 5 Ohms to about 50 Ohms and is configured to generate a localized heat capable of altering the permeability characteristics of barrier cells of an organism to become permeable when a voltage is applied across the disruptor;
a reservoir on the first side of the transdermal sampling and analysis device, wherein the reservoir comprises;
a collection portion configured to collect and contain a biological sample that is obtained through the permeable barrier cells; and
a sensing chamber configured with a plurality of channels formed between a plurality of channel supports;
a biological sensing element comprising at least two sensing electrodes mounted on the first side of the substrate, wherein the biological sensing element is configured to determine the levels of an analyte in the biological sample;
a lid configured to enclose the reservoir and the at least two sensing electrodes within a volume formed in the reservoir;
a spacer disposed on top of the substrate; and
a lid adhesive layer adhering the lid to the spacer, wherein the lid adhesive layer has a hydrophilic wetting angle that is less than 40°
,wherein the sensing chamber is configured to contain the biological sample around the at least two sensing electrodes, wherein the biological sample is directed over the surface of the at least two sensing electrodes by the plurality of channels.
7 Assignments
0 Petitions
Accused Products
Abstract
Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.
-
Citations
69 Claims
-
1. A transdermal sampling and analysis device comprising:
-
a substrate having a first side; a disruptor mounted on the first side of the substrate, wherein the disruptor has a resistance of about 5 Ohms to about 50 Ohms and is configured to generate a localized heat capable of altering the permeability characteristics of barrier cells of an organism to become permeable when a voltage is applied across the disruptor; a reservoir on the first side of the transdermal sampling and analysis device, wherein the reservoir comprises; a collection portion configured to collect and contain a biological sample that is obtained through the permeable barrier cells; and a sensing chamber configured with a plurality of channels formed between a plurality of channel supports; a biological sensing element comprising at least two sensing electrodes mounted on the first side of the substrate, wherein the biological sensing element is configured to determine the levels of an analyte in the biological sample; a lid configured to enclose the reservoir and the at least two sensing electrodes within a volume formed in the reservoir; a spacer disposed on top of the substrate; and a lid adhesive layer adhering the lid to the spacer, wherein the lid adhesive layer has a hydrophilic wetting angle that is less than 40°
,wherein the sensing chamber is configured to contain the biological sample around the at least two sensing electrodes, wherein the biological sample is directed over the surface of the at least two sensing electrodes by the plurality of channels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
-
-
58. A system comprising:
a transdermal sampling and analysis device comprising; a substrate having a first side; a disruptor mounted on the first side of the substrate, wherein the disruptor has a resistance of about 5 Ohms to about 50 Ohms and is configured to generate a localized heat capable of altering the permeability characteristics of barrier cells of an organism to become permeable when a voltage is applied across the disruptor; a reservoir on the first side of the transdermal sampling and analysis device, wherein the reservoir comprises; a collection portion configured to collect and contain a biological sample that is obtained through the permeable barrier cells; and a sensing chamber configured with a plurality of channels formed between a plurality of channel supports; a biological sensing element comprising at least two sensing electrodes mounted on the first side of the substrate, wherein the biological sensing element is configured to determine the levels of an analyte in the biological sample; a lid configured to enclose the reservoir and the at least two sensing electrodes within a volume formed in the reservoir; a spacer disposed on top of the substrate; and a lid adhesive layer adhering the lid to the spacer, wherein the lid adhesive layer has a hydrophilic wetting angle that is less than 40°
,wherein the sensing chamber is configured to contain the biological sample around the at least two sensing electrodes, wherein the biological sample is directed over the surface of the at least two sensing electrodes by the plurality of channels; and
an applicator device comprising;a housing configured to selectively engage the transdermal sampling and analysis device; a processor, wherein the processor is coupled to the at least two sensing electrodes when the transdermal sampling and analysis device is engaged; a display coupled to the processor; a memory coupled to the processor; and a voltage source coupled to the processor and for providing a voltage signal to the at least one disruptor when the transdermal sampling and analysis device is engaged, wherein the processor is configured to modify the voltage signal provided by the voltage source and apply the modified voltage signal to the at least one disruptor, and wherein the processor is configured to receive electrical signals from the at least two sensing electrodes and determine the levels of analyte present in the biological sample. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
Specification