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Method of administering amantadine prior to a sleep period

DC
  • US 9,877,933 B2
  • Filed: 02/09/2017
  • Issued: 01/30/2018
  • Est. Priority Date: 12/02/2009
  • Status: Active Grant
First Claim
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1. A method of treating a patient with Parkinson'"'"'s disease, comprising administering once daily, 0 to 4 hours before bedtime, to said patient with Parkinson'"'"'s disease, a pharmaceutical composition comprising:

  • (i) 220 mg to 455 mg of a drug selected from the group consisting of amantadine and a pharmaceutically acceptable salt thereof; and

    (ii) one or more excipients, wherein at least one of said one or more excipients modifies the release of said drug to provide an extended release dosage form,wherein ON time without troublesome dyskinesia is increased in said patient with Parkinson'"'"'s disease, andwherein when said pharmaceutical composition is dosed in a single dose, fasted, human pharmacokinetic study in healthy subjects, the Tmax for the drug is 8 to 20 hours.

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