Cyclic olefin polymer vessels and vessel coating methods
First Claim
Patent Images
1. A package containing a pharmaceutical composition, the package comprising:
- a container comprising a syringe barrel having a wall defining a lumen, the wall having a wall interior surface consisting essentially of a cyclic olefin polymer (COP) free of co-monomers,a barrier coating on at least a portion of the wall interior surface, the coating consisting essentially of a material comprising the atomic ratio SiOx measured by X-ray photoelectron spectroscopy (XPS), in which x is from 1.5 to 2.9, anda plasma enhanced chemical vapor deposition (PECVD) lubricity coating over the barrier coating, comprising the following atomic ratio, measured by XPS,
SiwOxCy where w is 1, x in this formula is from about 0.5 to 2.4, and y is from about 0.6 to about 3, the wall interior surface coated with the barrier coating and the lubricity coating having at least 25% lower sliding frictional resistance or at least 25% lower breakout frictional resistance than the wall interior surface lacking the barrier coating and the lubricity coating, as measured in accordance with ISO 7886-1;
1993; and
a composition contained in the lumen comprising;
one or more active medicaments which are at least one of a protein, a peptide, or a DNA sequence;
a water; and
at least one organic preservative.
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Abstract
A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.
957 Citations
8 Claims
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1. A package containing a pharmaceutical composition, the package comprising:
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a container comprising a syringe barrel having a wall defining a lumen, the wall having a wall interior surface consisting essentially of a cyclic olefin polymer (COP) free of co-monomers, a barrier coating on at least a portion of the wall interior surface, the coating consisting essentially of a material comprising the atomic ratio SiOx measured by X-ray photoelectron spectroscopy (XPS), in which x is from 1.5 to 2.9, and a plasma enhanced chemical vapor deposition (PECVD) lubricity coating over the barrier coating, comprising the following atomic ratio, measured by XPS,
SiwOxCywhere w is 1, x in this formula is from about 0.5 to 2.4, and y is from about 0.6 to about 3, the wall interior surface coated with the barrier coating and the lubricity coating having at least 25% lower sliding frictional resistance or at least 25% lower breakout frictional resistance than the wall interior surface lacking the barrier coating and the lubricity coating, as measured in accordance with ISO 7886-1;
1993; anda composition contained in the lumen comprising; one or more active medicaments which are at least one of a protein, a peptide, or a DNA sequence; a water; and at least one organic preservative. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification