Vascular occlusion and drug delivery devices, systems, and methods
First Claim
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1. A vascular delivery device comprising:
- an inner expandable member; and
an outer drug delivery component comprising a drug infusible layer and being associated with the inner expandable member,wherein the outer drug delivery component is configured to deliver a therapeutic agent upon pressurizing the inner expandable member to a pressure threshold less than 5 psi above an ambient pressure,wherein the inner expandable member and the outer drug delivery component are evertable, andwherein the inner expandable member comprises a substantially impermeable, tubular form and is not in fluid communication with the outer drug delivery component.
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Abstract
Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.
42 Citations
17 Claims
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1. A vascular delivery device comprising:
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an inner expandable member; and an outer drug delivery component comprising a drug infusible layer and being associated with the inner expandable member, wherein the outer drug delivery component is configured to deliver a therapeutic agent upon pressurizing the inner expandable member to a pressure threshold less than 5 psi above an ambient pressure, wherein the inner expandable member and the outer drug delivery component are evertable, and wherein the inner expandable member comprises a substantially impermeable, tubular form and is not in fluid communication with the outer drug delivery component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 17)
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10. A method of delivering a therapeutic agent comprising:
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infusing a drug delivery component comprising an inner drug infusible layer with a therapeutic agent; and pressurizing an expandable member and thereby everting and extending the drug delivery component and the expandable member through a lumen of a vessel; and pressurizing the expandable member to a pressure threshold less than 20 psi above an ambient pressure to deliver the therapeutic agent to a surrounding tissue, wherein the expandable member comprises a substantially impermeable tubular form and is not in fluid communication with the drug delivery component. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification