Methods and systems for increasing heart contractility by neuromodulation
First Claim
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1. A method of increasing heart contractility by applying an electrical therapy signal from an intraluminal electrode, the method comprising:
- introducing a therapy signal delivery device through an internal jugular vein and into a pulmonary artery with aid of a Swan-Ganz catheter, the therapy signal delivery device comprising;
the intraluminal electrode;
an expandable frame comprising a superelastic material, the expandable frame comprising;
a first collapsed configuration; and
a second expanded configuration designed to contact a wall of the pulmonary artery against which the intraluminal electrode is positioned,the pulmonary artery including at least one of;
a pulmonary trunk; and
a right pulmonary artery; and
applying the electrical therapy signal to the intraluminal electrode positioned in the pulmonary artery to modulate an autonomic cardiopulmonary fiber surrounding the pulmonary artery,the autonomic cardiopulmonary fiber comprising at least one of;
a right dorsal medial cardiopulmonary nerve,a right dorsal lateral cardiopulmonary nerve,a left ventral cardiopulmonary nervea left dorsal medial cardiopulmonary nerve,a left dorsal lateral cardiopulmonary nerve, anda left stellate cardiopulmonary nerve,the electrical therapy signal being a biphasic waveform.
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Abstract
Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.
441 Citations
20 Claims
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1. A method of increasing heart contractility by applying an electrical therapy signal from an intraluminal electrode, the method comprising:
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introducing a therapy signal delivery device through an internal jugular vein and into a pulmonary artery with aid of a Swan-Ganz catheter, the therapy signal delivery device comprising; the intraluminal electrode; an expandable frame comprising a superelastic material, the expandable frame comprising; a first collapsed configuration; and a second expanded configuration designed to contact a wall of the pulmonary artery against which the intraluminal electrode is positioned, the pulmonary artery including at least one of; a pulmonary trunk; and a right pulmonary artery; and applying the electrical therapy signal to the intraluminal electrode positioned in the pulmonary artery to modulate an autonomic cardiopulmonary fiber surrounding the pulmonary artery, the autonomic cardiopulmonary fiber comprising at least one of; a right dorsal medial cardiopulmonary nerve, a right dorsal lateral cardiopulmonary nerve, a left ventral cardiopulmonary nerve a left dorsal medial cardiopulmonary nerve, a left dorsal lateral cardiopulmonary nerve, and a left stellate cardiopulmonary nerve, the electrical therapy signal being a biphasic waveform. - View Dependent Claims (2, 3, 4)
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5. A method of increasing heart contractility by applying an electrical therapy signal from an intraluminal electrode, the method comprising:
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introducing a therapy signal delivery device through a vein and into a pulmonary artery, the therapy signal delivery device comprising; the intraluminal electrode; an expandable frame comprising a superelastic material, the expandable frame comprising; a first collapsed configuration; and a second expanded configuration designed to contact a wall of the pulmonary artery against which the intraluminal electrode is positioned, the pulmonary artery including at least one of; a pulmonary trunk; and a right pulmonary artery; and modulating an autonomic cardiopulmonary fiber surrounding the pulmonary artery, modulating the autonomic cardiopulmonary fiber comprising applying the electrical therapy signal to the intraluminal electrode positioned in the pulmonary artery. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A method of increasing heart contractility by applying an electrical therapy signal from an intraluminal electrode, the method comprising:
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introducing a therapy signal delivery device into a pulmonary artery, the therapy signal delivery device comprising; the intraluminal electrode; an expandable frame comprising; a first collapsed configuration; and a second expanded configuration designed to contact a wall of the pulmonary artery against which the intraluminal electrode is positioned; and applying the electrical therapy signal to the intraluminal electrode positioned in the pulmonary artery to modulate an autonomic cardiopulmonary fiber surrounding the pulmonary artery. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification