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Assays for TIMP2 having improved performance in biological samples

  • US 9,879,091 B2
  • Filed: 08/07/2014
  • Issued: 01/30/2018
  • Est. Priority Date: 08/07/2013
  • Status: Active Grant
First Claim
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1. A method for determining the presence or amount of human TIMP2 in a biological sample, comprising:

  • performing an immunoassay on the biological sample with a first monoclonal antibody and a second monoclonal antibody which together form sandwich complexes with human TIMP2, wherein the immunoassay provides a detectable signal that is related to the presence or amount of human TIMP2 in the biological sample bound in the sandwich complexes; and

    relating the detectable signal to the presence or amount of human TIMP2 in the biological sample, wherein one or both of the first monoclonal antibody and second monoclonal antibody—

    is a monoclonal antibody that binds with an affinity of at least 108 M

    1
    to a polypeptide, wherein the sequence of said polypeptide consists of a sequence selected from the group consisting of;

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