Modular nucleotide compositions and uses therefor
First Claim
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1. A sequencing reaction mixture comprising a nucleoside polyphosphate coupled to a functional group by a non-covalent linkage component through a phosphate group of the polyphosphate, wherein the functional group comprises a detectable label.
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Abstract
Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses.
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22 Claims
- 1. A sequencing reaction mixture comprising a nucleoside polyphosphate coupled to a functional group by a non-covalent linkage component through a phosphate group of the polyphosphate, wherein the functional group comprises a detectable label.
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