Colorimetric sensor arrays based on nanoporous pigments

• US 9,880,137 B2
• Filed: 09/02/2009
• Issued: 01/30/2018
• Est. Priority Date: 09/04/2008
• Status: Active Grant

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Lim, Sung H., Musto, Christopher J., Feng, Liang, Kemling, Jonathan W., Suslick, Kenneth S.
• Primary Examiner(s): Boyer, Randy
• Application Number:
  US12/552,899
• Publication Number:
  US 20100166604A1
• Time in Patent Office: 3,072 Days
• CPC Class Codes: G01N 21/253 for batch operation, i.e. multisample apparatus analytical automats G01N35/00
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence

Abstract

A colorimetric array includes a substrate, a first spot on the substrate, and a second spot on the substrate. The first spot includes a first nanoporous pigment that includes a first nanoporous material and a first immobilized, chemoresponsive colorant. The second spot includes a second nanoporous pigment that includes a second nanoporous material and a second immobilized, chemoresponsive colorant. The first nanoporous pigment is different from the second nanoporous pigment.

Claims

1. A colorimetric sensor array comprising:

a substrate;

a first spot on the substrate, comprising a first nanoporous pigment, the first nanoporous pigment comprising a first nanoporous material and a first immobilized, chemoresponsive colorant; and

a second spot on the substrate, comprising a second nanoporous pigment, the second nanoporous pigment comprising a second nanoporous material and a second immobilized, chemoresponsive colorant;

where the first nanoporous pigment differs from the second nanoporous pigment, and

where the first and second nanoporous pigments are cross-reactive with one another with respect to at least one analyte,

where the first immobilized, chemoresponsive colorant comprises a chemoresponsive pigment,

where the chemoresponsive pigment is a porous pigment.

2. The colorimetric sensor array of claim 1, where the first immobilized, chemoresponsive colorant comprises a dye insolubilized by the first nanoporous material.

3. The colorimetric sensor array of claim 2, where the dye is selected from the group consisting of a Lewis acid-base dye, a structure sensitive porphyrin, a pH sensitive dye, a solvatochromic dye, a vapochromic dye, a redox sensitive dye, and a metal ion sensitive dye.

4. The colorimetric sensor array of claim 2, where the dye is a Lewis acid-base dye selected from the group consisting of a metal-ion containing dye, a boron-containing dye, a boronic acid containing dye, and a dye comprising an accessible heteroatom having a lone electron pair.

5. The colorimetric sensor array of claim 4, where the dye is a metal-ion containing dye selected from the group consisting of a metalloporphyrin, a salen complex, a chlorin, a bispocket porphyrin, and a phthalocyanine.

6. The colorimetric sensor array of claim 2, where the dye is a structure sensitive porphyrin selected from the group consisting of a tetrakis(2,4,6-trimethoxyphenyl)-porphyrin, a silylether-metalloporphyrin, and a siloxyl-substituted bis-pocket porphyrin.

7. The colorimetric sensor array of claim 2, where the dye is a pH sensitive dye selected from the group consisting of a Bronsted acid dye and a Bronsted base dye.

8. The colorimetric sensor array of claim 2, where the dye is responsive to at least one chemical interaction selected from the group consisting of Lewis acid-base interaction, Bronsted acid-base interaction, ligand binding, π

-π

complexation, hydrogen bonding, polarization, oxidation/reduction, and metal coordination.

9. The colorimetric sensor array of claim 1, where the first immobilized, chemoresponsive colorant comprises a chemoresponsive nanoparticle.

10. The colorimetric sensor array of claim 9, where the chemoresponsive nanoparticle is selected from the group consisting of a nanoporous porphyrin solid, a semiconductor nanoparticle, and a metal nanoparticle.

11. The colorimetric sensor array of claim 1, where the first and second nanoporous materials are the same, and the first and second immobilized, chemoresponsive colorants are different.

12. The colorimetric sensor array of claim 1, where the first and second nanoporous materials are different, and the first and second immobilized, chemoresponsive colorants are the same.

13. The colorimetric sensor array of claim 1, where the first and second nanoporous materials are different, and the first and second immobilized, chemoresponsive colorants are different.

14. The colorimetric sensor array of claim 1, further comprising a plurality of additional spots on the substrate, each spot of the plurality independently comprising a chemoresponsive colorant.

15. The colorimetric sensor array of claim 14, where at least one spot of the plurality comprises an additional nanoporous pigment, different from the first and second nanoporous pigments.

16. The colorimetric sensor array of claim 14, where each spot of the plurality independently comprises an additional nanoporous pigment, different from the first and second nanoporous pigments.

17. The colorimetric sensor array of claim 16, where each additional nanoporous pigment of the plurality is different.

18. The colorimetric sensor array of claim 1, further comprising an oxidizing source to pretreat the analyte gas stream before contact with the colorimetric sensor array.

19. The colorimetric sensor array of claim 18, wherein the oxidizing source comprises an oxidizing agent.

20. The colorimetric sensor array of claim 19, wherein the oxidizing agent is a solid oxidant.

21. The colorimetric sensor array of claim 19, further comprising an oxidation catalyst wherein the oxidation catalyst comprises a heterogeneous catalyst.

24. The colorimetric sensor array of claim 1, wherein said colorimetric sensor array is configured to generate a color difference map, wherein the color difference map comprises changes in spectral properties that occur upon exposure of the at least one analyte to the first and second nanoporous pigments.

25. The colorimetric sensor array of claim 1, wherein the first and second nanoporous pigments are cross-reactive with one another with respect to greater than one analyte.

22. A colorimetric sensor array for determining the identity and concentration of an analyte, comprising:

a substrate; and

a plurality of nanoporous pigments on the substrate,

wherein each member of the plurality of nanoporous pigments comprises a nanoporous material and an immobilized, chemoresponsive colorant, provided that at least one member of the plurality of nanoporous pigments differs from another member of the plurality of nanoporous pigments,

wherein each member of the plurality of nanoporous pigments is cross-reactive with other members of the plurality of nanoporous pigments with respect to the analyte, and

wherein the colorimetric sensor array is configured to determine the identity and concentration of the analyte based upon a pattern of color change associated with interaction of the analyte with the plurality of nanoporous pigments,

where the immobilized, chemoresponsive colorant comprises a chemoresponsive pigment,

where the chemoresponsive pigment is a porous pigment.

26. The colorimetric sensor array of claim 22, wherein said colorimetric sensor array is configured to generate a color difference map, wherein the color difference map comprises changes in spectral properties that occur upon exposure of the analyte to the plurality of nanoporous pigments.

27. The colorimetric sensor array of claim 22, wherein each member of the plurality of nanoporous pigments is cross-reactive with other members of the plurality of nanoporous pigments with respect to greater than one analyte.

23. A colorimetric sensor array for determining the identity and concentration of an analyte, comprising:

a substrate; and

a plurality of nanoporous pigments and chemoresponsive dyes on the substrate,

wherein each member of the plurality of nanoporous pigments comprises a nanoporous material and an immobilized, chemoresponsive colorant,

wherein at least one member of the plurality of nanoporous pigments and chemoresponsive dyes differs from another member of the plurality of nanoporous pigments and chemoresponsive dyes,

wherein each member of the plurality of nanoporous pigments and chemoresponsive dyes is cross-reactive with other members of the plurality of nanoporous pigments and chemoresponsive dyes with respect to the analyte, and

wherein the colorimetric sensor array is configured to determine the identity and concentration of the analyte based upon a pattern of color change associated with interaction of the analyte with the plurality of nanoporous pigments and chemoresponsive dyes,

where the immobilized, chemoresponsive colorant comprises a chemoresponsive pigment,

where the chemoresponsive pigment is a porous pigment.

28. The colorimetric sensor array of claim 23, wherein the colorimetric sensor array is configured to generate a color difference map, wherein the color difference map comprises the pattern of color change associated with interaction of the at least one analyte with the plurality of nanoporous pigments and chemoresponsive dyes.

29. The colorimetric sensor array of claim 23, wherein each member of the plurality of nanoporous pigments and chemoresponsive dyes is cross-reactive with other members of the plurality of nanoporous pigments and chemoresponsive dyes with respect to greater than one analyte.