Articles of manufacture releasing an active ingredient

• US 9,883,710 B2
• Filed: 08/13/2010
• Issued: 02/06/2018
• Est. Priority Date: 07/18/2008
• Status: Active Grant

• Current Assignee: Nntt Tech Inc.
• Original Assignee: BioMed Concepts, Inc.
• Inventors: Theberge, Karine, Goudreault, Isabelle, Quirion, Francois, Perron, Gerald
• Primary Examiner(s): FISHER, MELISSA L
• Application Number:
  US12/855,783
• Publication Number:
  US 20110010817A1
• Time in Patent Office: 2,734 Days
• Field of Search: None
• CPC Class Codes: A43B 1/0045 made at least partially of deodorant means
• CPC Class Codes: A43B 17/003 characterised by the material made of wood A43B17/12, made of sponge, rubber or plastic materials A43B17/14
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: D06M 23/08 Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00
• CPC Class Codes: D06M 23/12 Processes in which the treating agent is incorporated in microcapsules making microcapsules B01J13/02

Abstract

The present invention relates to articles of manufacture having a formulation distributed therein, wherein the formulation comprises an active agent which manifests a desirable property when released from the articles of manufacture. The present invention also relates to methods for manufacturing these articles of manufacture, to vehicles for applying the formulation to these articles of manufacture, and to perception indicators indicating the presence and the amount of formulation comprising an active agent applied to an article of manufacture.

Claims

1. A method for delivering an active ingredient to a living subject, comprising:

a) obtaining a formulation of hydrophobic microparticles, the hydrophobic microparticles having a body, the body comprising a central part having an outer surface, wherein the outer surface is substantially hydrophobic,

the central part and its substantially hydrophobic outer surface including a non-crosslinked carrier material throughout which is dispersed the active ingredient,

wherein the non-crosslinked carrier material includes one or more of a fatty acid-based lipid, a fatty acid, a phospholipid, a wax, a sterol, and a glyceride;

b) transferring the formulation of hydrophobic microparticles to a substrate; and

c) placing the substrate in contact with the living subject;

wherein the temperature, pH, or both of the living subject triggers progressive erosion of the substantially hydrophobic outer surface and the subsequent progressive erosion of the central part to release the non-crosslinked carrier material and the active ingredient for delivery to the living subject;

wherein at least a portion of the substantially hydrophobic outer surface of the central part is exposed to the environment exterior to the hydrophobic microparticles when the substrate is in a pre-usage, stored state; and

wherein the formulation optionally comprises a cationic surfactant, the cationic surfactant being present in the formulation, exterior to the microparticles.

2. A method as defined in claim 1, wherein friction between the substrate and the living subject further triggers the progressive erosion of the substantially hydrophobic outer surface and the subsequent progressive erosion of the central part of the body of the microparticle.

3. A method as defined in claim 1, wherein the substrate is composed of a material selected from the group consisting of woven materials, a non-woven materials, fibrous textiles, non-fibrous textile, fabrics, synthetic materials, papers and paper products, products made from composites, products made from polymers, products made from wood or wood by-products, products made from carbon fiber, products made from glass fiber and synthetic foam.

4. A method as defined in claim 1, wherein the non-crosslinked carrier material is caproic acid, caprylic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, a fatty acid derivative, tripalmitin, tristearin or glycerol monostearate or any combination thereof.

5. A method as defined in claim 1, wherein the non-crosslinked carrier material includes a fatty alcohol.

6. A method as defined in claim 1, wherein the non-crosslinked carrier material includes an emollient.

7. A method as defined in claim 1, wherein the formulation further comprises a binding agent.

8. A method as defined in claim 7, wherein the binding agent is a polyacrylic (PAC), a polyurethane (PU), a polysiloxane (POL), a polyvinylpyrrolidone (PVP), a guar gum or an acrylic base or any combination thereof.

9. A method as defined in claim 1, wherein one or more of the hydrophobic microparticles have a size in the range from about 0.1 μ

m and about 200 μ

m.

10. A method as defined in claim 1, wherein the hydrophobic microparticles have a melting temperature between about 20°

C. and about 60°

C.

11. A method as defined in claim 1, wherein the hydrophobic microparticles have a release index between 2 and 7.

12. A method as defined in claim 1, the body being entirely made of a mixture of the non-crosslinked carrier material and the active ingredient, wherein the non-crosslinked carrier material and the active ingredient are uniformly distributed throughout the body.

13. A method as defined in claim 1, wherein the hydrophobic microparticles have a melting temperature between 31°

C. and 34.5°

C.

14. A method as defined in claim 1, wherein the formulation of hydrophobic microparticles forms a perception indicator on the substrate.

15. A method as defined in claim 14, wherein the perception indicator is a) a visual indicator;

b) a wear indicator;

or c) a combination of a) and b).

16. The method of claim 1, wherein transferring the formulation of hydrophobic microparticles from the substrate to the living subject is effected by a dry transfer.

17. A method as defined in claim 1, wherein the active ingredient is a therapeutic agent.

18. A method as defined in claim 1, wherein the active ingredient is a cosmetic agent.