Hemodialysis system with cassette-based blood and dialysate pumping

• US 9,884,144 B2
• Filed: 05/11/2015
• Issued: 02/06/2018
• Est. Priority Date: 11/05/2003
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Lo, Ying-Cheng, Childers, Robert W., Kelly, Thomas D., Rohde, Justin
• Primary Examiner(s): Su, Susan
• Application Number:
  US14/708,614
• Publication Number:
  US 20150238679A1
• Time in Patent Office: 1,002 Days
• CPC Class Codes: A61M 1/1522 the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1563 Details of incorporated filters
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1603 Regulation parameters
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1635 with volume chamber balancing devices between used and fresh dialysis fluid
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3401 Cassettes therefor
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36224 : with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 : with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 : at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 : Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362265 : Details of valves
• CPC Class Codes: A61M 1/3627 : Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 2205/127 : with provisions for heating or cooling
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: Y10T 29/49826 : Assembling or joining

Abstract

A hemodialysis system includes: (i) a dialyzer; (ii) a dialysate source; a dialysate pump; (iii) a dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette in fluid communication with the dialyzer; (iv) a blood pump; and (v) a blood cassette separate from the dialysate cassette, the blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette, the blood cassette including a housing, the housing including a from-patient tube connector, a to-patient tube connector, a saline/priming tube connnector, a to-dialyzer tube connector, a from-dialyzer tube connector, and an internal air separation chamber.

Claims

1. A hemodialysis system comprising:

a dialyzer;

a fresh dialysate pump actuator;

a used dialysate pump actuator;

a dialysate cassette including at least one flexible membrane, the dialysate cassette in fluid communication with the dialyzer and structured and arranged to operate with (i) the fresh dialysate pump actuator to pump fresh dialysate fluid through the dialysate cassette, and (ii) the used dialysate pump actuator to pump used dialysate fluid through the dialysate cassette;

a peristaltic blood pump actuator;

at least one blood pressure sensor; and

a blood disposable separate from the dialysate cassette, the blood disposable operatively connected to the peristaltic blood pump actuator to pump blood through the blood disposable, the blood disposable including at least one blood pressure sensing area positioned and arranged for operable engagement with the at least one blood pressure sensor.

2. The hemodialysis system of claim 1, wherein (i) the at least one blood pressure sensor includes a venous blood pressure sensor and an arterial blood pressure sensor, (ii) the at least one blood pressure sensing area includes (a) a venous blood pressure sensing area operable with the venous blood pressure sensor, and (b) an arterial blood pressure sensing area operable with the arterial blood pressure sensor.

3. The hemodialysis system of claim 1, wherein the at least one flexible membrane of the dialysate cassette at least partially defines a dialysate fluid chamber.

4. The hemodialysis system of claim 1, wherein the blood disposable includes an air separation chamber structured and arranged to remove air from blood in the blood disposable.

5. The hemodialysis system of claim 1, which includes a dialysate fluid source in fluid communication with the dialysate cassette.

6. The hemodialysis system of claim 1, wherein the dialysate cassette includes a rigid portion and at least one dialysate pumping tube connected to the rigid portion for operation with the dialysate pump actuator.

7. The hemodialysis system of claim 1, wherein the blood disposable includes a rigid portion and at least one blood pumping tube extending from the rigid portion for operation with the peristaltic blood pump actuator.

8. The hemodialysis system of claim 1, wherein a flexible portion of the blood disposable defines at least one valve seat.

9. The hemodialysis system of claim 1, wherein at least one of the fresh dialysate pump actuator and the used dialysate pump actuator is a linear peristaltic pump actuator.

10. The hemodialysis system of claim 1, wherein the dialysate cassette includes an ultrafiltration balance chamber.

11. The hemodialysis system of claim 10, wherein the at least one flexible membrane at least partially defines the ultrafiltration balance chamber.

12. The hemodialysis system of claim 1, which includes a dialysis machine, and wherein the dialysate cassette is positioned on a front portion of the dialysis machine.

13. The hemodialysis system of claim 12, wherein the dialysis machine is structured and arranged to receive the blood disposable at the front portion of the dialysis machine adjacent to the dialysate cassette.

14. A hemodialysis system comprising:

a dialyzer;

a fresh dialysate pump actuator;

a used dialysate pump actuator;

a dialysate cassette assembly including at least one flexible membrane, the dialysate cassette assembly in fluid communication with the dialyzer and structured and arranged to operate with (i) the fresh dialysate pump actuator to pump fresh dialysate fluid through the dialysate cassette assembly, and (ii) the used pump actuator to pump used dialysate fluid through the dialysate cassette assembly;

a blood pump actuator;

at least one blood pressure sensor; and

a blood disposable separate from the dialysate cassette, the blood disposable operatively connected to the blood pump such that the blood pump actuator can pump blood through the blood disposable, the blood disposable including at least one patient port, at least one dialyzer port, and at least one blood pressure sensing area positioned and arranged for operable engagement with the at least one blood pressure sensor.

15. The hemodialysis system of claim 14, wherein at least one of the used dialysate pump actuator and the blood pump actuator is a linear peristaltic pump actuator.

16. The hemodialysis system of claim 14, wherein the blood disposable further includes a blood pumping tube for operable connection to the blood pump actuator.

17. The hemodialysis system of claim 14, wherein the at least one blood pressure sensor includes an arterial pressure sensor and a venous pressure sensor, and wherein the at least one blood pressure sensing area includes arterial and venous pressure sensing areas that mate with the arterial and venous pressure sensors, respectively.

18. The hemodialysis system of claim 14, which includes at least one temperature sensor, and wherein the blood disposable further includes at least one temperature sensing area positioned and arranged for operable engagement with the at least one temperature sensor.

19. The hemodialysis system of claim 14, wherein the dialysate cassette assembly includes a fresh dialysate pumping tube operable with the fresh dialysate pump actuator, a used dialysate pumping tube operable with the used dialysate pump actuator, and a pair of balance chambers operable to ensure that an equal volume of fresh and used dialysate fluid is pumped in the dialysate cassette.

20. The hemodialysis system of claim 14, wherein the blood disposable includes a rigid portion and a pumping tube, the pumping tube located outside of the rigid portion and extending along a first side of the rigid portion, the pumping tube operatively connected to the blood pump such that the blood pump in operation contacts the pumping tube for pumping blood through the blood disposable, and wherein the at least one patient port and the at least one dialyzer port extends along a side of the rigid portion different from the first side of the rigid portion.

21. The hemodialysis system of claim 14, which includes an air sensor configured to sense whether air is present in blood pumped in the blood disposable.