Parallel modules for in-line recharging of sorbents using alternate duty cycles

• US 9,884,145 B2
• Filed: 04/23/2014
• Issued: 02/06/2018
• Est. Priority Date: 11/26/2013
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Pudil, Bryant J., Gerber, Martin T., Lura, David B., Meyer, Thomas E.
• Primary Examiner(s): GURTOWSKI, RICHARD C
• Application Number:
  US14/259,589
• Publication Number:
  US 20150144539A1
• Time in Patent Office: 1,385 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: B01D 15/1871 placed in series
• CPC Class Codes: B01D 15/22 relating to the construction of the column
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/06 comprising oxides or hydroxides of metals not provided for in group B01J20/04
• CPC Class Codes: B01J 20/08 comprising aluminium oxide or hydroxide; comprising bauxite
• CPC Class Codes: B01J 20/20 comprising free carbon; comprising carbon obtained by carbonising processes
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 2220/62 In a cartridge
• CPC Class Codes: B01J 39/12 Compounds containing phosphorus
• CPC Class Codes: G01N 30/6091 Cartridges

Abstract

Parallel modules for in-line recharging of sorbent materials using alternate duty cycles for a sorbent cartridge. The sorbent cartridge can have two or more modules contained therein having connectors connecting each of the modules. One or more of the modules can be reusable and the sorbent materials therein can be recharged.

Claims

1. A sorbent cartridge, comprising:

at least two modules, wherein the at least two modules are positioned parallel to one another;

the modules having one or more connectors fluidly connectable to any one of a fluid flow path, a bypass line wherein the bypass line is fluidly connectable to another module or fluid flow path, and a wash line;

wherein the wash line is fluidly connectable to a recharger capable of recharging spent sorbent material to or near an original state or usable capacity;

wherein at least one connector is a recharger connector fluidly connectable to a wash line.

2. The sorbent cartridge of claim 1, further comprising valves positioned before and/or after the modules on the connectors to selectively direct flow through the modules, fluid flow paths, wash lines, or bypass lines.

3. The sorbent cartridge of claim 2, further comprising valves positioned before and/or after the modules on the connectors to selectively direct flow through the modules.

4. The sorbent cartridge of claim 2 or 3, wherein the valve is any one of a two-way, three-way, four-way valve or combinations thereof.

5. The sorbent cartridge of claim 1, wherein at least one of the modules is configured to be in an offline state by being fluidly connectable to one or more recharger, and

at least one of the modules is configured to be in an online state by being fluidly connectable to any one of the fluid flow path or the bypass line.

6. The sorbent cartridge of claim 2, wherein a first module is positioned in series before a second and third module, wherein the second and third module are positioned parallel to one another.

7. The sorbent cartridge of claim 6, wherein the first module is connected to a first connector;

the first connector having a first valve, wherein the first valve connects the first connector, a second connector, a third connector, and a fourth connector;

wherein the second connector connects the first valve to the second module;

wherein the third connector connects the first valve to the third module;

wherein the fourth connector connects the first valve to a second valve, wherein the second valve connects the fourth connector, a fifth connector, a sixth connector, and a seventh connector;

wherein the fifth connector connects the second valve to the second module;

wherein the sixth connector connects the second valve to the third module; and

wherein the seventh connector connects the second valve to another section of the sorbent cartridge; and

wherein at least one of the first module, the second module, or the third module is fluidly connected to the recharger connector.

8. The sorbent cartridge of claim 3, wherein a first module is positioned in series before a second and third module, wherein the second and third module are positioned parallel to one another;

wherein the first module is connected to a first connector;

the first connector having a first valve.

9. The sorbent cartridge of claim 8, wherein the first valve connects the first connector, a second connector, a third connector, and a fourth connector;

wherein the second connector connects the first valve to a second valve, wherein the second valve connects the second connector, a first wash line and the second module;

wherein the first wash line connects the second valve to a first recharger connector;

wherein the third connector connects the first valve to a third valve, wherein the third valve connects the third connector, a second wash line and the third module;

wherein the second wash line connects the third valve to a second recharger connector;

wherein the fourth connector connects the first valve to a sixth valve, wherein the sixth valve connects the fourth connector, a fifth connector, a sixth connector, and a seventh connector;

wherein the fifth connector connects the sixth valve to a fourth valve, wherein the fourth valve connects the fifth connector, a third wash line and the second module;

wherein the third wash line connects the fourth valve to a third recharger connector;

wherein the sixth connector connects the sixth valve to a fifth valve, wherein the fifth valve connects the sixth connector, a fourth wash line and the third module;

wherein the fourth wash line connects the fifth valve to a fourth recharger connector; and

wherein the seventh connector connects the sixth valve to another section of the sorbent cartridge.

10. The sorbent cartridge of claim 3, wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, and the first and second modules are in series with the third and fourth modules.

11. The sorbent cartridge of claim 10, wherein a first valve connects a first, second, third and fourth connector;

wherein the second connector connects the first valve to a second valve, wherein the second valve connects the second connector, a first wash line and the first module;

wherein the first wash line connects the second valve to a first recharger connector;

wherein the third connector connects the first valve to a third valve, wherein the third valve connects the third connector, a second wash line, and the second module;

wherein the second wash line connects the third valve to a second recharger connector;

wherein the fourth connector connects the first valve to a tenth valve, wherein the tenth valve connects the fourth connector, a fifth connector, a sixth connector and an eleventh valve;

wherein the fifth connector connects the tenth valve to a fourth valve, wherein the fourth valve connects the fifth connector, a third wash line, and the first module;

wherein the third wash line connects the fourth valve to a third recharger connector;

wherein the sixth connector connects the tenth valve to a fifth valve, wherein the fifth valve connects the sixth connector, a fourth wash line and the second module;

wherein the fourth wash line connects a fourth recharger connector;

wherein the eleventh valve connects the fourth connector, a seventh connector, an eighth connector and a twelfth valve;

wherein the seventh connector connects the eleventh valve to a sixth valve, wherein the sixth valve connects the seventh connector, a fifth wash line and the third module;

wherein the fifth wash line connects a fifth recharger connector;

wherein the eighth connector connects the eleventh valve to a seventh valve, wherein the seventh valve connects the eighth connector, a sixth wash line and the fourth module;

wherein the sixth wash line connects the seventh valve to a sixth recharger connector;

wherein the twelfth valve connects the fourth connector, a ninth connector and a tenth connector;

wherein the ninth connector connects the twelfth valve to an eighth valve, wherein the eighth valve connects the ninth connector, a seventh wash line and the third module;

wherein the seventh wash line connects the eighth valve to a seventh recharger connector;

wherein the tenth connector connects the twelfth valve to a ninth valve, wherein the ninth valve connects the tenth connector, an eighth wash line and the fourth module; and

wherein the eighth wash line connects the ninth valve to an eighth recharger connector.

12. The sorbent cartridge of claim 3, wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, and the first and second modules are in series with the third and fourth modules.

13. The sorbent cartridge of claim 12, wherein a first valve connects a first, second, third and fourth connector;

wherein the second connector connects the first valve to a second valve, wherein the second valve connects the second connector, a first wash line and the first module;

wherein the first wash line connects the second valve to a first recharger connector;

wherein the third connector connects the first valve to a third valve, wherein the third valve connects the third connector, a second wash line and the second module;

wherein the second wash line connects the third valve to a second recharger connector;

wherein the fourth connector connects the first valve to a twelfth valve, wherein the twelfth valve connects the fourth connector, a fifth connector, a sixth connector and a thirteenth valve;

wherein the fifth connector connects the twelfth valve to a sixth valve, wherein the sixth valve connects the fifth connector, a fourth valve and an eighth valve;

wherein the fourth valve connects the sixth valve, a third wash line and the first module;

wherein the third wash line connects the fourth valve to a third recharger connector;

wherein the sixth connector connects the twelfth valve to a seventh valve, wherein the seventh valve connects the sixth connector, a ninth valve and a fifth valve;

wherein the fifth valve connects the seventh valve, a fourth wash line and the second module;

wherein the fourth wash line connects the fifth valve to a fourth recharger connector;

wherein the eighth valve connects the sixth valve, a fifth wash line and the third module;

wherein the fifth wash line connects the eighth valve to a fifth recharger connector;

wherein the ninth valve connects the seventh valve, a sixth wash line and the fourth module;

wherein the sixth wash line connects the ninth valve to a sixth recharger connector;

wherein the thirteenth valve connects the fourth connector, a seventh connector and an eighth connector;

wherein the seventh connector connects the thirteenth valve to a tenth valve, wherein the tenth valve connects the seventh connector, a seventh wash line and the third module;

wherein the seventh wash line connects the tenth valve to a seventh recharger connector;

wherein the eighth connector connects the thirteenth valve to an eleventh valve, wherein the eleventh valve connects the eighth connector, an eighth wash line and the fourth module; and

wherein the eighth wash line connects the eleventh valve to an eighth recharger connector.

14. The sorbent cartridge of claim 2, wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, a fifth and sixth module are positioned parallel to one another and the first and second modules are in series with the third and fourth modules, and the third and fourth modules are in series with the fifth and sixth modules.

15. The sorbent cartridge of claim 14, wherein a first valve connects a first, second, third and fourth connector;

wherein the second connector connects the first valve to a second valve, wherein the second valve connects the second connector, a first wash line and the first module;

wherein the first wash line connects the second valve to a first recharger connector;

wherein the third connector connects the first valve to a third valve, wherein the third valve connects the third connector, a second wash line, and the second module;

wherein the second wash line connects the third valve to a second recharger connector;

wherein the fourth connector connects the first valve to a fourteenth valve, wherein the fourteenth valve connects the fourth connector, a fifth connector, a sixth connector and a fifteenth valve;

wherein the fifth connector connects the fourteenth valve to a fourth valve, wherein the fourth valve connects the fifth connector, a third wash line, and the first module;

wherein the third wash line connects the fourth valve to a third recharger connector;

wherein the sixth connector connects the fourteenth valve to a fifth valve, wherein the fifth valve connects the sixth connector, a fourth wash line and the second module;

wherein the fourth wash line connects a fourth recharger connector;

wherein the fifteenth valve connects the fourth connector, a seventh connector, an eighth connector and a sixteenth valve;

wherein the seventh connector connects the fifteenth valve to a sixth valve, wherein the sixth valve connects the seventh connector, a fifth wash line and the third module;

wherein the fifth wash line connects a fifth recharger connector;

wherein the eighth connector connects the fifteenth valve to a seventh valve, wherein the seventh valve connects the eighth connector, a sixth wash line and the fourth module;

wherein the sixth wash line connects the seventh valve to a sixth recharger connector;

wherein the sixteenth valve connects the fourth connector, a ninth connector, a tenth connector and a seventeenth valve;

wherein the ninth connector connects the sixteenth valve to an eighth valve, wherein the eighth valve connects the ninth connector, a seventh wash line and the third module;

wherein the seventh wash line connects the eighth valve to a seventh recharger connector;

wherein the tenth connector connects the sixteenth valve to a ninth valve, wherein the ninth valve connects the tenth connector, an eighth wash line and the fourth module;

wherein the eighth wash line connects the ninth valve to an eighth recharger connector;

wherein the seventeenth valve connects the fourth connector, an eleventh connector, a twelfth connector and an eighteenth valve;

wherein the eleventh connector connects the seventeenth valve to a tenth valve, wherein the tenth valve connects the eleventh connector, a ninth wash line and the fifth module;

wherein the ninth wash line connects the tenth valve to a ninth recharger connector;

wherein the twelfth connector connects the seventeenth valve to an eleventh valve;

wherein the eleventh valve connects the twelfth connector a tenth wash line and the sixth module;

wherein the tenth wash line connects the eleventh valve to a tenth recharger connector;

wherein the eighteenth valve connects the fourth connector, a thirteenth connector and a fourteenth connector;

wherein the thirteenth connector connects the eighteenth valve to a twelfth valve;

wherein the twelfth valve connects the thirteenth connector, an eleventh wash line and the fifth module;

wherein the eleventh wash line connects the twelfth valve to an eleventh recharger connector;

wherein the fourteenth connector connects the eighteenth valve to a thirteenth valve;

wherein the thirteenth valve connects the fourteenth connector, a twelfth wash line and the sixth module; and

wherein the twelfth wash line connects the thirteenth valve and a twelfth recharger connector.

16. The sorbent cartridge of claim 1, comprising at least one reusable module having one or more connectors, wherein the connector is a recharger connector.

17. The sorbent cartridge of claim 1, wherein the cartridge comprises at least one non-reusable module.

18. The sorbent cartridge of claim 16, wherein the at least one reusable module contains sorbent material.

19. The sorbent cartridge of claim 16, wherein the at least one reusable module contains multiple sorbent materials.

20. The sorbent cartridge of claim 17, wherein the at least one non-reusable module contains sorbent material.

21. The sorbent cartridge of claim 17, wherein the at least one non-reusable module contains multiple sorbent materials.

22. The sorbent cartridge of claim 1, wherein the one or more connectors connecting the modules are selected from a group comprising quick-connect, twist-lock, push-on, and threaded fittings.

23. The sorbent cartridge of claim 1, wherein the one or more connectors comprise a length of tubing and a valve assembly.

24. The sorbent cartridge of claim 18, wherein the sorbent material is selected from a group comprising zirconium phosphate, hydrous zirconium oxide, activated carbon, alumina, urease, and ion exchange resin.

25. The sorbent cartridge of claim 20, wherein the sorbent material is selected from a group comprising zirconium phosphate, hydrous zirconium oxide, activated carbon, alumina, urease, and ion exchange resin.

26. The sorbent cartridge of claim 16, wherein the module is detachable from the sorbent cartridge.

27. The sorbent cartridge of claim 16, wherein the reusable module is recyclable.

28. The sorbent cartridge of claim 1, wherein at least one of the modules has an identification component to identify matching status of the module with respect to another object prior to attachment of the module to the sorbent cartridge.

29. The sorbent cartridge of claim 2, wherein the connectors include an access point for a sensor.

33. The sorbent cartridge of claim 1, wherein the at least two modules are part of a controlled compliant dialysis circuit.

34. The sorbent cartridge of claim 2, wherein the valves are operated under control of a programmable controller or computer system to regulate flow into, out of, and between modules.

35. The sorbent cartridge of claim 2, wherein fluid flow through the valves is sensed by a photocell or other flow sensing and/or measuring apparatus.

36. The sorbent cartridge of claim 1, further comprising a control pump for circulating fluid in the fluid flow path.

37. The sorbent cartridge of claim 19, wherein the multiple sorbent materials are mixed together.

38. The sorbent cartridge of claim 2 wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, a fifth and sixth module are positioned parallel to one another and the first and second modules are in series with the third and fourth modules, and the third and fourth modules are in series with the fifth and sixth modules.

39. The sorbent cartridge of claim 38, wherein the first and second modules are fluidly connected to a first set of one or more valves positioned on a first set of one or more connectors before the first and second modules, such that fluid may be directed into either the first or second module;

wherein a bypass line is fluidly connected to the first set of one or more valves such that fluid can bypass both the first and second module;

wherein a first recharger connector is fluidly connected to the first set of one or more valves such that fluid may be directed from the first recharger connector to either the first or second module;

wherein the first module, second module, and bypass line are fluidly connected to a second set of one or more valves positioned on a second set of one or more connectors after the first and second modules and before the third and fourth modules, such that fluid may be directed from the first or second module into either the third or fourth module;

wherein the bypass line is fluidly connected to the second set of one or more valves such that fluid can bypass both the third and fourth module;

wherein a second recharger connector is fluidly connected to the second set of one or more valves such that fluid may be directed from the second recharger connector to either the third or fourth module;

wherein the third module, fourth module, and bypass line are fluidly connected to a third set of one or more valves positioned on a third set of one or more connectors after the third and fourth modules and before the fifth and sixth modules, such that fluid may be directed from the third or fourth module into either the fifth or sixth module;

wherein the bypass line is fluidly connected to the third set of one or more valves such that fluid can bypass both the fifth and sixth module; and

wherein a third recharger connector is fluidly connected to the third set of one or more valves such that fluid may be directed from the third recharger connector to either the fifth or sixth module.

40. The sorbent cartridge of claim 2, wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, and the first and second modules are in series with the third and fourth modules.

41. The sorbent cartridge of claim 40, wherein the first and second modules are fluidly connected to a first set of one or more valves positioned on a first set of one or more connectors before the first and second modules, such that fluid may be directed into either the first or second module;

wherein a bypass line is fluidly connected to the first set of one or more valves such that fluid can bypass both the first and second module;

wherein a first recharger connector is fluidly connected to the first set of one or more valves such that fluid may be directed from the first recharger connector to either the first or second module;

wherein the first module, second module, and bypass line are fluidly connected to a second set of one or more valves positioned on a second set of one or more connectors after the first and second modules and before the third and fourth modules, such that fluid may be directed from the first or second module into either the third or fourth module;

wherein the bypass line is fluidly connected to the second set of one or more valves such that fluid can bypass both the third and fourth module; and

wherein a second recharger connector is fluidly connected to the second set of one or more valves such that fluid may be directed from the second recharger connector to either the third or fourth module.

42. The sorbent cartridge of claim 2, further comprising a first module positioned in series before a second and third module, the second and third module positioned parallel to one another;

the first module is connected to a set of one or more connectors positioned after the first module and before the second and third modules;

where a set of one or more valves is positioned on the set of one or more connectors such that fluid may be directed into either the second or third module;

wherein a bypass line is fluidly connected to the set of one or more valves such that fluid can bypass both the second and third module; and

a recharger connector is fluidly connected to the set of one or more valves such that fluid may be directed from the recharger connector to either the second or third module.

43. The sorbent cartridge of claim 2, further comprising a first and second module positioned parallel to one another, a third and fourth module positioned parallel to one another, a fifth and sixth module positioned parallel to one another and the first and second modules are in series with the third and fourth modules, and the third and fourth modules are in series with the fifth and sixth modules.

44. The sorbent cartridge of claim 43, further comprising the first and second modules are fluidly connected to a first set of one or more valves positioned on a first set of one or more connectors before the first and second modules, such that fluid may be directed into either the first or second module;

wherein a bypass line is fluidly connected to the first set of one or more valves such that fluid can bypass both the first and second module;

wherein the first module, second module, and bypass line are fluidly connected to a second set of one or more valves positioned on a second set of one or more connectors after the first and second modules and before the third and fourth modules, such that fluid may be directed from the first or second module into either the third or fourth module;

wherein the bypass line is fluidly connected to the second set of one or more valves such that fluid can bypass both the third and fourth module;

wherein the third module, fourth module, and bypass line are fluidly connected to a third set of one or more valves positioned on a third set of one or more connectors after the third and fourth modules and before the fifth and sixth modules, such that fluid may be directed from the third or fourth module into either the fifth or sixth module; and

wherein the bypass line is fluidly connected to the third set of one or more valves such that fluid can bypass both the fifth and sixth module; and

wherein at least one of the first module, second module, third module, fourth module, fifth module, and sixth module are fluidly connected to the recharger connector.

45. The sorbent cartridge of claim 2, wherein a first and second module are positioned parallel to one another, a third and fourth module are positioned parallel to one another, and the first and second modules are in series with the third and fourth modules, respectively.

46. The sorbent cartridge of claim 45, wherein the first and second modules are fluidly connected to a first set of one or more valves positioned on a first set of one or more connectors before the first and second modules, such that fluid may be directed into either the first or second module;

wherein a bypass line is fluidly connected to the first set of one or more valves such that fluid can bypass both the first and second module;

wherein the first module, second module, and bypass line are fluidly connected to a second set of one or more valves positioned on a second set of one or more connectors after the first and second modules and before the third and fourth modules, such that fluid may be directed from the first or second module into either the third or fourth module; and

wherein the bypass line is fluidly connected to the second set of one or more valves such that fluid can bypass both the third and fourth module; and

wherein at least one of the first module, second module, third module, and fourth module are fluidly connected to the recharger connector.

47. The sorbent cartridge of claim 2, wherein a first module is positioned in series before a second and third module, wherein the second and third module are positioned parallel to one another;

wherein the first module is connected to a set of one or more connectors positioned after the first module and before the second and third modules;

where a set of one or more valves is positioned on the set of one or more connectors such that fluid may be directed into either the second or third module; and

wherein a bypass line is fluidly connected to the set of one or more valves such that fluid can bypass both the second and third module; and

wherein at least one of the first module, second module, and third module are fluidly connected to the recharger connector.

48. The sorbent cartridge of claim 14, wherein the first and second modules contain urease, the third and fourth modules contain zirconium phosphate and the fifth and sixth modules contain zirconium oxide.

49. The sorbent cartridge of claim 48, wherein the first and second modules further contain activated carbon.

50. The sorbent cartridge of claim 49, wherein the first and second modules contain a first layer of activated carbon, a second layer of urease downstream of the first layer, and a third layer of activated carbon downstream of the second layer.

51. The sorbent cartridge of claim 48, wherein fluid or gas in the bypass line is controlled to bypass the urease in at least one of the first and second modules.

52. The sorbent cartridge of claim 51, wherein the bypass is controlled according to capacity of the zirconium phosphate in at least one of the third and fourth modules.

53. The sorbent cartridge of claim 28, wherein the at least one module is matched up to one or more of a particular patient or the sorbent cartridge according to the identification component.

30. A fluid circuit, comprising:

at least two modules in parallel, each module connected by one or more connectors;

an operational line directing flow along the connectors and through the modules;

at least one wash line fluidly connecting at least one of the connectors to a recharger capable of recharging spent sorbent material to or near an original state or usable capacity wherein the at least one connector is a recharger connector; and

at least one bypass line to bypass at least one of the modules and the operational line.

31. The fluid circuit of claim 30, wherein the operational line directing flow along the connectors through the modules is fluidly connected to one or more modules in an online state by being fluidly connectable to any one of the fluid flow path or the bypass line.

32. The fluid circuit of claim 30, wherein the operational line directing flow along the connectors through the modules is fluidly connected to one or more modules in an offline state by being fluidly connectable to one or more recharger.