Catheter system providing step reduction for postconditioning

• US 9,884,171 B2
• Filed: 08/28/2013
• Issued: 02/06/2018
• Est. Priority Date: 04/30/2010
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ehrenreich, Kevin, Magana, Jesus
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US14/011,934
• Publication Number:
  US 20140171865A1
• Time in Patent Office: 1,623 Days
• CPC Class Codes: A61M 2025/0183 Rapid exchange or monorail catheters
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1077 having a system for expelling the air out of the balloon before inflation and use
• CPC Class Codes: A61M 2025/1093 having particular tip characteristics
• CPC Class Codes: A61M 25/0172 Exchanging a guidewire while keeping the catheter in place
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 25/1018 Balloon inflating or inflation-control devices
• CPC Class Codes: A61M 25/10181 Means for forcing inflation fluid into the balloon
• CPC Class Codes: A61M 25/10187 Indicators for the level of inflation or deflation
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

A pre-assembled kit for administering ischemic postconditioning comprising a catheter and a handle having a fluid circuit to control and modulate flow of inflation fluid to and from a balloon wherein the catheter is free from additional assembly and preparation procedures such that it is ready-to-use within a variety of vessel sizes.

Claims

1. A system for administering ischemic postconditioning comprising:

a catheter including at least one expandable member, an inflation lumen, a dedicated independent deflation lumen, a drug delivery lumen that allows delivery of a therapeutic agent distal to the expandable member, and a guidewire lumen, the catheter configured for positioning within a variety of vessel sizes, the catheter configured to receive a rapid exchange guidewire of a predetermined size through the guidewire lumen;

a handle having a pressure source positioned entirely within the handle, and coupled to the catheter,

wherein the at least one expandable member is in fluid communication with the pressure source and is inflatable with an inflation fluid via the inflation lumen for a period of time upon positioning at a predetermined location within a vessel and deflatable via the deflation lumen,

wherein the catheter is configured to deliver a therapeutic agent while the catheter is coupled with a rapid exchange guidewire, and

wherein the handle includes an actuator operatively connected to the pressure source to affect inflation of the at least one expandable member via the inflation lumen, and to affect deflation of the at least one expandable member via the deflation lumen, the affected inflation and deflation defining a one-way fluid circuit.

2. The system of claim 1, wherein a therapeutic agent is delivered simultaneously with the postconditioning.

3. The system of claim 1, wherein the expandable member conforms to the vessel wall at a pressure of about ⅔

atm.

4. The system of claim 1, wherein the expandable member is configured for inflation for about 30 seconds.

5. The system of claim 1, wherein the inflation fluid is CO₂.

6. The system of claim 1, wherein the at least one expandable member is configured for repeated inflation.

7. The system of claim 1, wherein the expandable member is a balloon.

8. The system of claim 1, wherein the expandable member is configured to conform to a lumen wall having a non-circular cross-section.

9. A system of administering ischemic postconditioning comprising:

a catheter including at least one expandable member, an inflation lumen, a dedicated independent deflation lumen, a drug delivery lumen that allows delivery delivery of a therapeutic agent distal to the expandable member, and a guidewire lumen, the catheter operable to be positioned within a variety of vessel sizes, the catheter configured to receive a rapid exchange guidewire of a predetermined size through the guidewire lumen;

a handle having a pressure source positioned entirely within the handle, the pressure source coupled to the catheter,

wherein the at least one expandable member is in fluid communication with the pressure source, inflatable with an inflation fluid via the inflation lumen for a period of time upon positioning at a predetermined location within a vessel, operable to deliver a therapeutic agent to a predetermined location within the vessel, and deflatable via the deflation lumen,

wherein the catheter is configured to deliver a therapeutic agent while the catheter is coupled with a rapid exchange guidewire, and

wherein the handle includes an actuator operatively connected to the pressure source to affect inflation of the at least one expandable member via the inflation lumen, and to affect deflation of the at least one expandable member via the deflation lumen, the affected inflation and deflation defining a one-way fluid circuit.

10. The system of claim 9, wherein the catheter is configured as a single-piece device.

11. The system of claim 9, wherein the expandable member conforms to the vessel wall at a pressure of about ⅔

atm.

12. The system of claim 9, wherein the expandable member is configured for inflation for about 30 seconds.

13. The system of claim 11, wherein the inflation fluid is CO₂.

14. The system of claim 11, wherein the at least one expandable member is configured for repeated inflation.

15. The system of claim 11, wherein the expandable member is a balloon.

16. The system of claim 11, wherein the expandable member is configured to conform to a lumen wall having a non-circular cross section.