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Systems and methods for intensity modulated radiation therapy

  • US 9,884,206 B2
  • Filed: 07/22/2016
  • Issued: 02/06/2018
  • Est. Priority Date: 07/23/2015
  • Status: Expired due to Fees
First Claim
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1. A method for performing intensity-modulated radiation therapy on a subject using a plurality of pencil beams, the method comprising:

  • identifying a volume of interest from a representation of the subject, the volume of interest divided into a total number of voxels;

    defining a plurality of sub-volumes, wherein a sub-volume comprises a number of contiguous, ordered voxels; and

    generating a treatment plan for intensity-modulated radiation therapy that satisfies dose constraints for each voxel within each of the plurality of sub-volumes;

    wherein generating the treatment plan comprises;

    determining a system of linear equations of the form Ax*=b or linear inequalities of the form bmin

    Ax*≦

    bmax where x* is a first vector comprising elements xi representing an ith component of a solution vector representing an actual intensity of an ith pencil beam, b is a second vector comprising elements bj representing a dose prescribed for a jth dose grid point, bmin is a third vector comprising elements bminj representing a minimum dose prescribed for a jth dose grid point, bmax is a fourth vector comprising elements bmaxj representing a maximum dose prescribed for a jth dose grid point, and A is a matrix comprising elements aij representing a dose delivered by the ith pencil beam of unit intensity to the jth dose grid point; and

    determining one or more feasible solutions x* to the system of equations or inequalities using a feasibility-seeking algorithm.

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