Long-acting polypeptides and methods of producing and administering same
First Claim
1. A method of treating a subject suffering from a fatigue syndrome following cancer chemotherapy or a chronic infection, wherein said subject is anemic, said method comprising administering to a subject a therapeutically effective amount of a polypeptide consisting of a chorionic gonadotropin carboxy terminal peptide (CTP) modified erythropoietin (EPO), said CTP-modified EPO consisting of one chorionic gonadotropin carboxy terminal peptide (CTP) attached to the amino terminus of said EPO, and two chorionic gonadotropin CTPs attached to the carboxy terminus of said EPO, wherein said polypeptide consists of a precursor or a mature polypeptide and optionally a signal peptide attached to the amino terminus of said one CTP, wherein said administration treats the anemic subject suffering from fatigue syndrome following cancer chemotherapy or a chronic infection, or any combination thereof.
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Abstract
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
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10 Claims
- 1. A method of treating a subject suffering from a fatigue syndrome following cancer chemotherapy or a chronic infection, wherein said subject is anemic, said method comprising administering to a subject a therapeutically effective amount of a polypeptide consisting of a chorionic gonadotropin carboxy terminal peptide (CTP) modified erythropoietin (EPO), said CTP-modified EPO consisting of one chorionic gonadotropin carboxy terminal peptide (CTP) attached to the amino terminus of said EPO, and two chorionic gonadotropin CTPs attached to the carboxy terminus of said EPO, wherein said polypeptide consists of a precursor or a mature polypeptide and optionally a signal peptide attached to the amino terminus of said one CTP, wherein said administration treats the anemic subject suffering from fatigue syndrome following cancer chemotherapy or a chronic infection, or any combination thereof.
Specification