Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms

• US 9,888,839 B2
• Filed: 05/02/2014
• Issued: 02/13/2018
• Est. Priority Date: 04/01/2009
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Korb, Donald R., Grenon, Stephen M., Bacich, Steve
• Primary Examiner(s): Mack, Ricky
• Assistant Examiner(s): Manikeu, Daniele
• Application Number:
  US14/268,647
• Publication Number:
  US 20140240671A1
• Time in Patent Office: 1,383 Days
• Field of Search: 351206, 351221, 351246, 351205, 351200, 600425, 600398
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: G06T 2207/30041 Eye; Retina; Ophthalmic
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on tear film characteristics analysis and dry eye symptoms are disclosed. In embodiments herein, imaging of the ocular tear film is performed during contact lens wear. An analysis of the image of the ocular tear film is performed to determine one or more tear film characteristics of the ocular tear film. The tear film characteristics can be used to determine the effect or possible effect of contact lens wear on the ocular tear film, and thus be used to determine contact lens intolerance of the patient. The tear film characteristics used to analyze contact lens intolerance based on images of the ocular tear film involving contact lens wear may include dry eye symptoms, including but not limited to tear film (e.g., lipid and/or aqueous) thickness, tear film viscosity, and tear film movement rate in the eye.

Claims

1. A method for diagnosing contact lens intolerance on an ocular tear film of a patient, comprising:

illuminating the ocular tear film of the patient with a contact lens disposed on a patient'"'"'s eye with a light source;

capturing in at least one first image of the ocular tear film with the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated with the light source;

isolating at least one contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film;

converting the at least one contact lens-based region of interest in the at least one first image into at least one contact lens-based color-based value;

comparing the at least one contact lens-based color-based value to a lipid layer-contact lens layer optical wave interference model; and

determining a contact lens-based tear film characteristic of the at least one contact lens-based region of interest of the ocular tear film based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

2. The method of claim 1, further comprising:

isolating at least one non-contact lens-based region of interest in the at least one first image where the contact lens is not present on the ocular tear film;

converting the at least one non-contact lens-based region of interest in the at least one first image into at least one non-contact lens-based color-based value;

comparing the at least one non-contact lens-based color-based value to a tear film layer optical wave interference model; and

determining a non-contact lens-based tear film characteristic of the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one non-contact lens-based color-based value to the tear film layer optical wave interference model.

3. The method of claim 2, further comprising:

determining a difference between the contact lens-based tear film characteristic to the non-contact lens-based tear film characteristic; and

generating a resulting differential tear film characteristic based on the determined difference between the contact lens-based tear film characteristic to the non-contact lens-based tear film characteristic.

4. The method of claim 2, wherein isolating the at least one non-contact lens-based region of interest in the at least one first image where the contact lens is not present comprises:

determining an edge of the contact lens in the at least one first image; and

isolating a defined area from the edge of the contact lens where the contact lens is not present on the ocular tear film in the at least one first image.

5. The method of claim 4, wherein determining the contact lens-based tear film characteristic comprises determining a slope of a meniscus of the ocular tear film in the at least one contact lens-based region of interest of the ocular tear film based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

6. The method of claim 1, wherein determining the contact lens-based tear film characteristic comprises measuring a tear film layer thickness (TFLT) of the at least one contact lens-based region of interest in the at least one first image based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

7. The method of claim 1, wherein determining the contact lens-based tear film characteristic comprises determining a viscosity of the ocular tear film in the at least one contact lens-based region of interest in the at least one first image based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

8. The method of claim 1, wherein determining the contact lens-based tear film characteristic comprises determining a movement rate of the ocular tear film in the at least one contact lens-based region of interest in the at least one first image based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

9. The method of claim 1, wherein determining the contact lens-based tear film characteristic comprises determining at least one of a size, a shape, a breakup, a break up time, or a disappearance of the ocular tear film in the at least one contact lens-based region of interest in the at least one first image based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

10. The method of claim 1, further comprising:

determining a type of contact lens disposed on the patient'"'"'s eye; and

generating the lipid layer-contact lens layer optical wave interference model based on the determined type of contact lens.

11. The method of claim 10, further comprising:

disposing the contact lens on an optical phantom comprised of at least one material layer disposed on a substrate, and having a refractive index ratio between the at least one material layer and the substrate to mimic or substantially mimic a refractive index ratio between a lipid layer and an aqueous layer of the ocular tear film;

illuminating the contact lens disposed on the optical phantom with the light source; and

generating the lipid layer-contact lens layer optical wave interference model based on calibrating a tear film optical wave interface model generated from a phantom image of the optical phantom without the contact lens disposed thereon.

12. The method of claim 1, further comprising capturing a background signal from the ocular tear film with the contact lens disposed on the patient'"'"'s eye in at least one background image;

and

wherein isolating the at least one contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film comprises;

subtracting the at least one background image from the at least one first image to generate at least one resulting image containing the optical wave interference of specularly reflected light from the ocular tear film with the background signal removed or reduced; and

isolating the at least one contact lens-based region of interest in the at least one resulting image where the contact lens is present on the ocular tear film.

13. The method of claim 12, comprising capturing the at least one background image when the light source is not illuminating the ocular tear film.

14. The method of claim 12, comprising capturing the at least one background image when the light source is illuminating the ocular tear film.

15. The method of claim 12, wherein capturing the background signal from the ocular tear film in the at least one background image further comprises not capturing specularly reflected light from the ocular tear film.

16. The method of claim 1, wherein the light source is comprised of a multi-wavelength Lambertian light source.

17. The method of claim 1, wherein the light source is comprised of a mono-chromatic light source.

18. The method of claim 1, further comprising displaying the at least one first image on a visual display.

19. The method of claim 1, further comprising displaying the at least one contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film on a visual display.

20. The method of claim 2, further comprising displaying the at least one non-contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film on a visual display.

21. An apparatus for diagnosing contact lens intolerance on an ocular tear film of a patient, comprising:

a light source configured to illuminate the ocular tear film of the patient with a contact lens disposed on a patient'"'"'s eye;

an imaging device configured to capture in at least one first image of the ocular tear film with the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated with the light source; and

a computer control system configured to;

isolate at least one contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film;

convert the at least one contact lens-based region of interest in the at least one first image into at least one contact lens-based color-based value;

compare the at least one contact lens-based color-based value to a lipid layer-contact lens layer optical wave interference model; and

determine a contact lens-based tear film characteristic of the at least one contact lens-based region of interest of the ocular tear film based on the comparison of the at least one contact lens-based color-based value to the lipid layer-contact lens layer optical wave interference model.

22. The apparatus of claim 21, wherein the computer control system is further configured to:

isolate at least one non-contact lens-based region of interest in the at least one first image where the contact lens is not present on the ocular tear film;

convert the at least one non-contact lens-based region of interest in the at least one first image into at least one first non-contact lens-based color-based value;

compare the at least one first non-contact lens-based color-based value to a tear film layer optical wave interference model; and

determine a non-contact lens-based tear film characteristic of the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model.

23. A method for diagnosing contact lens intolerance in a patient, comprising:

illuminating an ocular tear film of the patient having a contact lens disposed on a patient'"'"'s eye with a light source;

capturing in at least one first image of the ocular tear film with the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated;

isolating at least one non-contact lens-based region of interest in the at least one first image where the contact lens is not present on the ocular tear film; and

determining a non-contact lens-based tear film characteristic of the at least one non-contact lens-based region of interest in the at least one first image.

24. The method of claim 23, wherein isolating the at least one non-contact lens-based region of interest comprises:

determining an edge of the contact lens in the at least one first image; and

isolating a defined area from the edge of the contact lens where the contact lens is not present on the ocular tear film in the at least one first image.

25. The method of claim 24, wherein determining the non-contact lens-based tear film characteristic comprises determining a slope of a meniscus of the ocular tear film in the at least one non-contact lens-based region of interest of the ocular tear film.

26. The method of claim 23, wherein determining the non-contact lens-based tear film characteristic comprises:

converting the at least one non-contact lens-based region of interest in the at least one first image into at least one first non-contact lens-based color-based value; and

comparing the at least one first non-contact lens-based color-based value to a tear film layer optical wave interference model.

27. The method of claim 26, further comprising determining at least one of a size, a shape, a breakup, a break up time, or a disappearance of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model.

28. The method of claim 26, further comprising measuring a tear film layer thickness (TFLT) of the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model.

29. The method of claim 26, further comprising determining a viscosity of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model.

30. The method of claim 26, further comprising determining a movement rate of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model.

31. The method of claim 23, further comprising:

illuminating the ocular tear film of the patient without the contact lens disposed on the patient'"'"'s eye;

capturing in at least one second image of the ocular tear film without the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated; and

determining a second non-contact lens-based tear film characteristic in at least one non-contact lens-based region of interest in the at least one second image.

32. The method of claim 31, further comprising comparing the non-contact lens-based tear film characteristic based on the contact lens disposed on the patient'"'"'s eye to the second non-contact lens-based tear film characteristic based on the contact lens not being disposed on the patient'"'"'s eye.

33. The method of claim 32, further comprising generating a resulting differential tear film characteristic based on the comparison of the non-contact lens-based tear film characteristic based on the contact lens disposed on the patient'"'"'s eye to the second non-contact lens-based tear film characteristic based on the contact lens not being disposed on the patient'"'"'s eye.

34. The method of claim 32, wherein comparing the non-contact lens-based tear film characteristic to the second non-contact lens-based tear film characteristic comprises subtracting the non-contact lens-based tear film characteristic from the second non-contact lens-based tear film characteristic.

35. The method of claim 31, wherein:

determining the non-contact lens-based tear film characteristic comprises;

converting the at least one non-contact lens-based region of interest in the at least one first image into at least one first non-contact lens-based color-based value; and

comparing the at least one first non-contact lens-based color-based value to a tear film layer optical wave interference model; and

determining the second non-contact lens-based tear film characteristic comprises;

converting the at least one non-contact lens-based region of interest in the at least one second image into at least one second non-contact lens-based color-based value; and

comparing the at least one second non-contact lens-based color-based value to the tear film layer optical wave interference model.

36. The method of claim 35, further comprising:

measuring a tear film layer thickness (TFLT) of the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model; and

measuring the TFLT of the at least one non-contact lens-based region of interest in the at least one second image based on the comparison of the at least one second non-contact lens-based color-based value to the tear film layer optical wave interference model.

37. The method of claim 35, further comprising:

determining a viscosity of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model; and

determining a viscosity of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one second image based on the comparison of the at least one second non-contact lens-based color-based value to the tear film layer optical wave interference model.

38. The method of claim 35, further comprising:

determining a movement rate of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one first image based on the comparison of the at least one first non-contact lens-based color-based value to the tear film layer optical wave interference model; and

determining a movement rate of the ocular tear film in the at least one non-contact lens-based region of interest in the at least one second image based on the comparison of the at least one second non-contact lens-based color-based value to the tear film layer optical wave interference model.

39. The method of claim 23, further comprising capturing a background signal from the ocular tear film with the contact lens disposed on the patient'"'"'s eye in at least one background image;

and

wherein isolating the at least one non-contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film comprises;

subtracting the at least one background image from the at least one first image to generate at least one resulting image containing the optical wave interference of specularly reflected light from the ocular tear film with the background signal removed or reduced; and

isolating the at least one non-contact lens-based region of interest in the at least one resulting image where the contact lens is present on the ocular tear film.

40. The method of claim 39, comprising capturing the at least one background image when the light source is illuminating the ocular tear film.

41. The method of claim 39, wherein capturing the background signal from the ocular tear film in the at least one background image further comprises not capturing specularly reflected light from the ocular tear film.

42. The method of claim 31, further comprising capturing a second background signal from the ocular tear film without the contact lens disposed on the patient'"'"'s eye in at least one second background image;

and

wherein isolating the at least one non-contact lens-based region of interest in the at least one second image without the contact lens present on the ocular tear film comprises;

subtracting the at least one second background image from the at least one second image to generate at least one second resulting image containing the optical wave interference of specularly reflected light from the ocular tear film with the second background signal removed or reduced; and

isolating the at least one non-contact lens-based region of interest in the at least one second resulting image without the contact lens present on the ocular tear film.

43. The method of claim 23, wherein the light source is comprised of a multi-wavelength Lambertian light source.

44. The method of claim 23, wherein the light source is comprised of a mono-chromatic light source.

45. The method of claim 23, further comprising displaying the at least one first image on a visual display.

46. The method of claim 31, further comprising displaying the at least one second image on a visual display.

47. The method of claim 23, further comprising displaying the at least one non-contact lens-based region of interest in the at least one first image where the contact lens is present on the ocular tear film on a visual display.

48. The method of claim 31, further comprising displaying the at least one non-contact lens-based region of interest in the at least one second image without the contact lens present on the ocular tear film on a visual display.

49. An apparatus for diagnosing contact lens intolerance in a patient, comprising:

an illuminator configured to illuminate an ocular tear film of the patient having a contact lens disposed on a patient'"'"'s eye;

an imaging device configured to capture in at least one first image of the ocular tear film with the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated;

a computer control system configured to;

isolate at least one non-contact lens-based region of interest in the at least one first image where the contact lens is not present on the ocular tear film; and

determine a non-contact lens-based tear film characteristic of the at least one non-contact lens-based region of interest in the at least one first image.

50. The apparatus of claim 49, wherein:

the illuminator is further configured to illuminate the ocular tear film of the patient without the contact lens disposed on the patient'"'"'s eye;

the imaging device is further configured to capture in at least one second image of the ocular tear film without the contact lens disposed on the patient'"'"'s eye, optical wave interference of specularly reflected light from the ocular tear film, when the ocular tear film is illuminated; and

the computer control system is further configured to determine a second non-contact lens-based tear film characteristic in the at least one non-contact lens-based region of interest in the at least one second image.