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Crystalline forms of therapeutic compounds and uses thereof

  • US 9,890,173 B2
  • Filed: 05/24/2017
  • Issued: 02/13/2018
  • Est. Priority Date: 11/01/2013
  • Status: Active Grant
First Claim
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1. A method of inhibiting growth factor signaling comprising administering to a subject in need thereof a therapeutically effective amount of a crystalline form of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one comprising:

  • (i) crystalline Form II having an X-ray powder diffraction (XRPD) pattern with peaks at about 8.44, 10.57, 14.92, 17.22, 21.26 and 22.42±

    0.2 degrees two theta, or 10.47, 8.36, 5.93, 5.15, 4.18 and 3.96±

    0.2 Å

    in d-spacing;

    or(ii) crystalline Form III having an XRPD pattern with peaks at about 9.60, 10.45, 19.30, 19.71, 21.84, and 23.42±

    0.2 degrees two theta or 9.21, 8.46, 4.60, 4.50, 4.07 and 3.80±

    0.2 Å

    in d-spacing.

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