Pore-forming protein conjugate compositions and methods
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Abstract
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
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Citations
18 Claims
- 1. A composition comprising a compound of formula (I),
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10. A method of preparing a conjugate of a pore-forming protein and a biomolecule capable of catalyzing the synthesis of a nucleotide polymer, said method comprising contacting under suitable reaction conditions:
a tetrazine-linker-conjugate compound of formula (II) - View Dependent Claims (11, 12)
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13. A method of preparing a conjugate of a pore-forming protein and a biomolecule capable of catalyzing the synthesis of a nucleotide polymer, said method comprising the steps of:
(a) contacting a pore-forming protein with a tetrazine-linker-maleimide compound of formula (V) under suitable reaction conditions; - View Dependent Claims (14, 15, 16, 17, 18)
Specification