Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
First Claim
1. An organ care system configured to perfuse an ex vivo heart in a functioning state at near physiological conditions, the system comprising:
- a chassis;
an organ chamber assembly mounted to the chassis for containing the ex vivo heart during perfusion in a functioning state at near physiological conditions, the organ chamber comprising;
a fluid conduit with a first interface configured to connect to an aorta of the heart and a second interface configured to connect to a pulmonary vein of the heart;
a Lactate A sensor configured to measure lactate in the first interface;
a Lactate V sensor configured to measure lactate in the second interface; and
a processor configured to calculate a Lactate V-A differential using lactate values measured by the Lactate A sensor and the Lactate V sensor,wherein the processor is configured to calculate Lactate V-A differential at two different times,wherein the processor is further configured to calculate a change in V-A differential between the two different times to correlate a change between the V-A lactate differentials over time with suitability of the heart for transplantation.
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Abstract
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell'"'"'s unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
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Citations
20 Claims
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1. An organ care system configured to perfuse an ex vivo heart in a functioning state at near physiological conditions, the system comprising:
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a chassis; an organ chamber assembly mounted to the chassis for containing the ex vivo heart during perfusion in a functioning state at near physiological conditions, the organ chamber comprising; a fluid conduit with a first interface configured to connect to an aorta of the heart and a second interface configured to connect to a pulmonary vein of the heart; a Lactate A sensor configured to measure lactate in the first interface; a Lactate V sensor configured to measure lactate in the second interface; and a processor configured to calculate a Lactate V-A differential using lactate values measured by the Lactate A sensor and the Lactate V sensor, wherein the processor is configured to calculate Lactate V-A differential at two different times, wherein the processor is further configured to calculate a change in V-A differential between the two different times to correlate a change between the V-A lactate differentials over time with suitability of the heart for transplantation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus comprising:
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an organ chamber assembly for containing the ex vivo heart during perfusion in a functioning state at near physiological conditions, the organ chamber comprising; a first fluid channel configured to be coupled to an aorta of an ex vivo heart; a second fluid channel configured to be coupled to a pulmonary vein of the heart; a first sensor configured to measure a Lactate A level in the first fluid channel; a second sensor configured to measure a Lactate V level in the second fluid channel; a processor coupled to the first and second sensors; and a memory coupled to the processor and including computer readable instructions that, when executed by the processor, cause the processor to; calculate a Lactate V-A differential at two different times using the measurements provided by the first and second sensors; and calculate a change in Lactate V-A differential between the two different times correlate the change between the Lactate V-A differentials over time with a suitability of the heart for transplantation. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification