Ocular delivery systems and methods

• US 9,895,258 B2
• Filed: 11/12/2014
• Issued: 02/20/2018
• Est. Priority Date: 03/20/2012
• Status: Active Grant

• Current Assignee: Sight Sciences, Inc.
• Original Assignee: Sight Sciences, Inc.
• Inventors: Badawi, David Y., O'Keeffe, Daniel, Badawi, Paul
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): SASS, SARA A
• Application Number:
  US14/539,648
• Publication Number:
  US 20150073328A1
• Time in Patent Office: 1,196 Days
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00736 Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments A61F9/008 takes precedence
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

Described here are systems and methods for accessing Schlemm'"'"'s canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm'"'"'s canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Claims

1. An ocular delivery device comprising:

a) a universal handle;

b) a cannula coupled to the universal handle and comprising an opening at a distal end;

c) a flexible polymer slidably disposed within and extendable from the distal opening, the flexible polymer having a length configured to advance 180 degrees around Schlemm'"'"'s canal, wherein the length of the portion of the flexible polymer extended from the distal opening is configured to cut trabeculocanalicular tissues during withdrawal of the cannula;

d) a housing; and

e) a wheeled drive assembly,

where the ocular delivery device is implant-free.

2. The ocular delivery device of claim 1, wherein the wheeled drive assembly comprises a single rotatable component.

3. The ocular delivery device of claim 1, wherein the wheeled drive assembly comprises a plurality of rotatable components.

4. The ocular delivery device of claim 1, wherein the flexible polymer has an outer diameter of between about 50 microns and about 500 microns.

5. The ocular delivery device of claim 4, wherein the flexible polymer has an outer diameter of about 240 microns.

12. The ocular delivery device of claim 1, wherein the flexible polymer is configured to extend about 20 mm from the distal opening.

13. The ocular delivery device of claim 12, wherein the flexible polymer is configured to extend about 36 to 40 mm from the distal opening.

6. A single-handed, single operator controlled device for lowering intraocular pressure comprising:

a) a cannula;

b) a flexible polymer slidably disposed within, and extendable distally from, the cannula, and the flexible polymer having a length configured to advance 180 degrees around Schlemm'"'"'s canal, wherein the length of the portion of the flexible polymer extended from the cannula is configured to cut trabeculocanalicular tissues during withdrawal of the cannula; and

c) a handle coupled to the cannula,

wherein the handle is configured to extend and retract the flexible polymer with a single hand, and wherein the device is implant-free.

7. The single-handed, single-operator controlled device of claim 6, wherein the flexible polymer has an outer diameter between about 50 microns and about 500 microns.

8. The single-handed, single-operator controlled device of claim 7, wherein the flexible polymer has an outer diameter of about 240 microns.

9. The single-handed, single-operator controlled device of claim 6, further comprising a wheeled drive assembly.

10. The single-handed, single-operator controlled device of claim 9, wherein the wheeled drive assembly comprises a single rotatable component.

11. The single-handed, single-operator controlled device of claim 9, wherein the wheeled drive assembly comprises a plurality of rotatable components.

14. The single-handed, single-operator controlled device of claim 6, further comprising a grasping element.

15. The single-handed, single-operator controlled device of claim 6, wherein the flexible polymer is configured to advance about a 180 degree arc into Schlemm'"'"'s canal.

16. The single-handed, single-operator controlled device of claim 6, wherein the flexible polymer is configured to advance about 360 degrees into Schlemm'"'"'s canal.